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    Bms1 BMS1, ribosome biogenesis factor [ Mus musculus (house mouse) ]

    Gene ID: 213895, updated on 26-Sep-2022

    Summary

    Official Symbol
    Bms1provided by MGI
    Official Full Name
    BMS1, ribosome biogenesis factorprovided by MGI
    Primary source
    MGI:MGI:2446132
    See related
    Ensembl:ENSMUSG00000030138 AllianceGenome:MGI:2446132
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bms1l; mKIAA0187
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and U3 snoRNA binding activity. Predicted to be involved in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in chromosome; nucleolus; and nucleoplasm. Predicted to be part of 90S preribosome. Human ortholog(s) of this gene implicated in nonsyndromic aplasia cutis congenita. Orthologous to human BMS1 (BMS1 ribosome biogenesis factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 14.2), liver E14 (RPKM 7.5) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Bms1 in Genome Data Viewer
    Location:
    6; 6 F1
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (118360342..118396772, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (118383381..118419802, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30557 Neighboring gene predicted gene, 30498 Neighboring gene zinc finger protein 248 Neighboring gene zinc finger protein 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0187

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables U3 snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of 90S preribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ribosome biogenesis protein BMS1 homolog
    Names
    BMS1 homolog, ribosome assembly protein
    BMS1-like, ribosome assembly protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_194339.2NP_919320.1  ribosome biogenesis protein BMS1 homolog

      See identical proteins and their annotated locations for NP_919320.1

      Status: VALIDATED

      Source sequence(s)
      AC140466
      Consensus CDS
      CCDS20471.1
      UniProtKB/TrEMBL
      Q6PGF5
      Related
      ENSMUSP00000032237.7, ENSMUST00000032237.8
      Conserved Domains (4) summary
      smart00785
      Location:231317
      AARP2CN; AARP2CN (NUC121) domain
      cd01882
      Location:44273
      BMS1; Bms1, an essential GTPase, promotes assembly of preribosomal RNA processing complexes
      COG5192
      Location:171275
      BMS1; GTP-binding protein required for 40S ribosome biogenesis [Translation, ribosomal structure and biogenesis]
      pfam04950
      Location:8211108
      RIBIOP_C; 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      118360342..118396772 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321497.3XP_017176986.1  ribosome biogenesis protein BMS1 homolog isoform X1

      Conserved Domains (1) summary
      COG5192
      Location:171301
      BMS1; GTP-binding protein required for 40S ribosome biogenesis [Translation, ribosomal structure and biogenesis]

    RNA

    1. XR_377435.5 RNA Sequence