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    Tbp TATA box binding protein [ Mus musculus (house mouse) ]

    Gene ID: 21374, updated on 1-Nov-2018

    Summary

    Official Symbol
    Tbpprovided by MGI
    Official Full Name
    TATA box binding proteinprovided by MGI
    Primary source
    MGI:MGI:101838
    See related
    Ensembl:ENSMUSG00000014767 Vega:OTTMUSG00000030550
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gtf2d; SCA17; TFIID; GTF2D1
    Expression
    Ubiquitous expression in testis adult (RPKM 40.6), CNS E14 (RPKM 17.0) and 27 other tissues See more
    Orthologs

    Genomic context

    See Tbp in Genome Data Viewer
    Location:
    17 A2; 17 8.95 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (15499888..15517427)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (15636852..15654391)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 120, member B Neighboring gene proteasome (prosome, macropain) subunit, beta type 1 Neighboring gene programmed cell death 2 Neighboring gene zinc finger protein 91 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II core promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II proximal promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II repressing transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    RNA polymerase III general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase III regulatory region DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    TFIIB-class transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    aryl hydrocarbon receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    core promoter binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    repressing transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA-templated transcription, initiation IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II preinitiation complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase III preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    transcription by RNA polymerase III IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription by RNA polymerase III ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    RNA polymerase I transcription factor complex TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    female pronucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    male pronucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear euchromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    pronucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor TFIIA complex ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcription factor TFIIIB complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcriptional preinitiation complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    TATA-box-binding protein
    Names
    TATA sequence-binding protein
    TATA-binding factor
    TATA-binding protein
    TATA-box factor
    TFIID core protein
    transcription initiation factor TFIID TBP subunit

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013684.3NP_038712.3  TATA-box-binding protein

      See identical proteins and their annotated locations for NP_038712.3

      Status: VALIDATED

      Source sequence(s)
      AC154378, AK085037
      Consensus CDS
      CCDS37454.2
      UniProtKB/Swiss-Prot
      P29037
      UniProtKB/TrEMBL
      Q6RI65
      Related
      ENSMUSP00000124317.1, OTTMUSP00000039699, ENSMUST00000162505.7, OTTMUST00000075644
      Conserved Domains (2) summary
      PLN00062
      Location:139315
      PLN00062; TATA-box-binding protein; Provisional
      cd04516
      Location:139312
      TBP_eukaryotes; eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      15499888..15517427
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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