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    Dis3l DIS3 like exosome 3'-5' exoribonuclease [ Mus musculus (house mouse) ]

    Gene ID: 213550, updated on 12-Aug-2018

    Summary

    Official Symbol
    Dis3lprovided by MGI
    Official Full Name
    DIS3 like exosome 3'-5' exoribonucleaseprovided by MGI
    Primary source
    MGI:MGI:2143272
    See related
    Ensembl:ENSMUSG00000032396 Vega:OTTMUSG00000031812
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AV340375
    Expression
    Broad expression in testis adult (RPKM 24.6), cerebellum adult (RPKM 6.8) and 25 other tissues See more
    Orthologs

    Genomic context

    See Dis3l in Genome Data Viewer
    Location:
    9; 9 C
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (64306756..64341426, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (64154563..64189064, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase 1 Neighboring gene ubiquitin carboxyl-terminal esterase L4 Neighboring gene timeless interacting protein Neighboring gene multiple EGF-like-domains 11 Neighboring gene predicted gene, 36311 Neighboring gene RAB11A, member RAS oncogene family

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    • RNA degradation, organism-specific biosystem (from KEGG)
      RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
    • RNA degradation, conserved biosystem (from KEGG)
      RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    3'-5'-exoribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    3'-5'-exoribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    RNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA phosphodiester bond hydrolysis, exonucleolytic IEA
    Inferred from Electronic Annotation
    more info
     
    rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    rRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasmic exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DIS3-like exonuclease 1
    Names
    DIS3 mitotic control homolog-like
    NP_001001295.2
    NP_001171255.1
    NP_766107.1
    XP_006511045.1
    XP_006511046.1
    XP_011241002.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001295.2NP_001001295.2  DIS3-like exonuclease 1 isoform 1

      See identical proteins and their annotated locations for NP_001001295.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC056939, BM900123, BY497083, CJ157436
      Consensus CDS
      CCDS52832.1
      UniProtKB/Swiss-Prot
      Q8C0S1
      Related
      ENSMUSP00000129772.2, ENSMUST00000168844.8
      Conserved Domains (3) summary
      COG0557
      Location:265899
      VacB; Exoribonuclease R [Transcription]
      pfam00773
      Location:465815
      RNB; RNB domain
      cl14812
      Location:12188
      PIN_SF; PIN (PilT N terminus) domain: Superfamily
    2. NM_001177784.1NP_001171255.1  DIS3-like exonuclease 1 isoform 2

      See identical proteins and their annotated locations for NP_001171255.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AC135358, AK077031, BM900123, BY497083
      Consensus CDS
      CCDS23280.1
      UniProtKB/Swiss-Prot
      Q8C0S1
      Related
      ENSMUSP00000113503.1, OTTMUSP00000041977, ENSMUST00000120760.7, OTTMUST00000078853
      Conserved Domains (3) summary
      COG0557
      Location:182816
      VacB; Exoribonuclease R [Transcription]
      pfam00773
      Location:382732
      RNB; RNB domain
      cl14812
      Location:2105
      PIN_SF; PIN (PilT N terminus) domain: Superfamily
    3. NM_172519.3NP_766107.1  DIS3-like exonuclease 1 isoform 2

      See identical proteins and their annotated locations for NP_766107.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK029974, BM900123, BY497083
      Consensus CDS
      CCDS23280.1
      UniProtKB/Swiss-Prot
      Q8C0S1
      Related
      ENSMUSP00000109522.1, OTTMUSP00000041978, ENSMUST00000113890.1, OTTMUST00000078854
      Conserved Domains (3) summary
      COG0557
      Location:182816
      VacB; Exoribonuclease R [Transcription]
      pfam00773
      Location:382732
      RNB; RNB domain
      cl14812
      Location:2105
      PIN_SF; PIN (PilT N terminus) domain: Superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      64306756..64341426 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510983.3XP_006511046.1  DIS3-like exonuclease 1 isoform X1

      See identical proteins and their annotated locations for XP_006511046.1

      Conserved Domains (2) summary
      COG0557
      Location:131765
      VacB; Exoribonuclease R [Transcription]
      pfam00773
      Location:331681
      RNB; RNB domain
    2. XM_011242700.1XP_011241002.1  DIS3-like exonuclease 1 isoform X1

      See identical proteins and their annotated locations for XP_011241002.1

      Conserved Domains (2) summary
      COG0557
      Location:131765
      VacB; Exoribonuclease R [Transcription]
      pfam00773
      Location:331681
      RNB; RNB domain
    3. XM_006510982.3XP_006511045.1  DIS3-like exonuclease 1 isoform X2

      See identical proteins and their annotated locations for XP_006511045.1

      UniProtKB/Swiss-Prot
      Q8C0S1
      Conserved Domains (3) summary
      COG0557
      Location:182816
      VacB; Exoribonuclease R [Transcription]
      pfam00773
      Location:382732
      RNB; RNB domain
      cl14812
      Location:2105
      PIN_SF; PIN (PilT N terminus) domain: Superfamily
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