Format

Send to:

Choose Destination
    • Showing Current items.

    Dis3l DIS3 like exosome 3'-5' exoribonuclease [ Mus musculus (house mouse) ]

    Gene ID: 213550, updated on 22-Aug-2021

    Summary

    Official Symbol
    Dis3lprovided by MGI
    Official Full Name
    DIS3 like exosome 3'-5' exoribonucleaseprovided by MGI
    Primary source
    MGI:MGI:2143272
    See related
    Ensembl:ENSMUSG00000032396
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AV340375
    Expression
    Broad expression in testis adult (RPKM 24.6), cerebellum adult (RPKM 6.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Dis3l in Genome Data Viewer
    Location:
    9; 9 C
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (64214038..64248707, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (64306756..64341403, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (64154563..64189064, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase 1 Neighboring gene ubiquitin carboxyl-terminal esterase L4 Neighboring gene timeless interacting protein Neighboring gene predicted gene, 24289 Neighboring gene multiple EGF-like-domains 11 Neighboring gene predicted gene, 36311 Neighboring gene RAB11A, member RAS oncogene family

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5'-exoribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 3'-5'-exoribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in rRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    part_of cytoplasmic exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of cytoplasmic exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DIS3-like exonuclease 1
    Names
    DIS3 mitotic control homolog-like
    NP_001001295.2
    NP_001171255.1
    NP_766107.1
    XP_006511045.1
    XP_011241002.1
    XP_030100066.1
    XP_036010677.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001295.2NP_001001295.2  DIS3-like exonuclease 1 isoform 1

      See identical proteins and their annotated locations for NP_001001295.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC056939, BM900123, BY497083, CJ157436
      Consensus CDS
      CCDS52832.1
      UniProtKB/Swiss-Prot
      Q8C0S1
      Related
      ENSMUSP00000129772.3, ENSMUST00000168844.9
      Conserved Domains (3) summary
      COG0557
      Location:265899
      VacB; Exoribonuclease R [Transcription]
      pfam00773
      Location:465815
      RNB; RNB domain
      cl14812
      Location:12188
      PIN_SF; PIN (PilT N terminus) domain: Superfamily
    2. NM_001177784.1NP_001171255.1  DIS3-like exonuclease 1 isoform 2

      See identical proteins and their annotated locations for NP_001171255.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AC135358, AK077031, BM900123, BY497083
      Consensus CDS
      CCDS23280.1
      UniProtKB/Swiss-Prot
      Q8C0S1
      Related
      ENSMUSP00000113503.2, ENSMUST00000120760.8
      Conserved Domains (3) summary
      COG0557
      Location:182816
      VacB; Exoribonuclease R [Transcription]
      pfam17215
      Location:792875
      Rrp44_S1; S1 domain
      cl28905
      Location:1105
      PIN_SF; PIN (PilT N terminus) domain: Superfamily
    3. NM_172519.3NP_766107.1  DIS3-like exonuclease 1 isoform 2

      See identical proteins and their annotated locations for NP_766107.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK029974, BM900123, BY497083
      Consensus CDS
      CCDS23280.1
      UniProtKB/Swiss-Prot
      Q8C0S1
      Related
      ENSMUSP00000109522.2, ENSMUST00000113890.2
      Conserved Domains (3) summary
      COG0557
      Location:182816
      VacB; Exoribonuclease R [Transcription]
      pfam17215
      Location:792875
      Rrp44_S1; S1 domain
      cl28905
      Location:1105
      PIN_SF; PIN (PilT N terminus) domain: Superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      64214038..64248707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244206.2XP_030100066.1  DIS3-like exonuclease 1 isoform X1

      Conserved Domains (3) summary
      COG0557
      Location:131765
      VacB; Exoribonuclease R [Transcription]
      pfam17215
      Location:741824
      Rrp44_S1; S1 domain
      cl28905
      Location:154
      PIN_SF; PIN (PilT N terminus) domain: Superfamily
    2. XM_011242700.3XP_011241002.1  DIS3-like exonuclease 1 isoform X1

      See identical proteins and their annotated locations for XP_011241002.1

      Conserved Domains (3) summary
      COG0557
      Location:131765
      VacB; Exoribonuclease R [Transcription]
      pfam17215
      Location:741824
      Rrp44_S1; S1 domain
      cl28905
      Location:154
      PIN_SF; PIN (PilT N terminus) domain: Superfamily
    3. XM_036154784.1XP_036010677.1  DIS3-like exonuclease 1 isoform X3

      Conserved Domains (2) summary
      COG0557
      Location:33602
      VacB; Exoribonuclease R [Transcription]
      pfam17215
      Location:578661
      Rrp44_S1; S1 domain
    4. XM_006510982.5XP_006511045.1  DIS3-like exonuclease 1 isoform X2

      See identical proteins and their annotated locations for XP_006511045.1

      UniProtKB/Swiss-Prot
      Q8C0S1
      Conserved Domains (3) summary
      COG0557
      Location:182816
      VacB; Exoribonuclease R [Transcription]
      pfam17215
      Location:792875
      Rrp44_S1; S1 domain
      cl28905
      Location:1105
      PIN_SF; PIN (PilT N terminus) domain: Superfamily
    Support Center