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    Ythdf2 YTH N6-methyladenosine RNA binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 213541, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ythdf2provided by MGI
    Official Full Name
    YTH N6-methyladenosine RNA binding protein 2provided by MGI
    Primary source
    MGI:MGI:2444233
    See related
    Ensembl:ENSMUSG00000040025
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HGRG; HGRG8; NY-RE; NY-REN-2; 9430020E02Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 11.2), whole brain E14.5 (RPKM 10.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ythdf2 in Genome Data Viewer
    Location:
    4; 4 D2.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (131912227..131939567, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132184916..132212256, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (131740831..131768171, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene opioid receptor, delta 1 Neighboring gene nuclear encoded tRNA alanine 3 (anticodon CGC) Neighboring gene predicted gene 13215 Neighboring gene ribosomal protein S15A, pseudogene 4 Neighboring gene glucocorticoid modulatory element binding protein 1 Neighboring gene cytochrome c-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables C5-methylcytidine-containing RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables N6-methyladenosine-containing RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables N6-methyladenosine-containing RNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables N6-methyladenosine-containing RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gamete generation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hematopoietic stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA destabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mRNA destabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within oogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in organelle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cap-independent translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in positive regulation of translational initiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of hematopoietic stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mRNA stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mRNA stability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of meiotic cell cycle process involved in oocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of rRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogonial cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in stress granule assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    YTH domain-containing family protein 2
    Names
    YTH domain family 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145393.4NP_663368.3  YTH domain-containing family protein 2

      See identical proteins and their annotated locations for NP_663368.3

      Status: VALIDATED

      Source sequence(s)
      AK034655, AK150669, BX537301
      Consensus CDS
      CCDS18719.1
      UniProtKB/Swiss-Prot
      Q91YT7
      Related
      ENSMUSP00000120414.2, ENSMUST00000152796.8
      Conserved Domains (1) summary
      pfam04146
      Location:411544
      YTH; YT521-B-like domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      131912227..131939567 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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