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    Rbbp5 retinoblastoma binding protein 5, histone lysine methyltransferase complex subunit [ Mus musculus (house mouse) ]

    Gene ID: 213464, updated on 2-Oct-2018

    Summary

    Official Symbol
    Rbbp5provided by MGI
    Official Full Name
    retinoblastoma binding protein 5, histone lysine methyltransferase complex subunitprovided by MGI
    Primary source
    MGI:MGI:1918367
    See related
    Ensembl:ENSMUSG00000026439 Vega:OTTMUSG00000049391
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C330016J05; 4933411J24Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.4), cerebellum adult (RPKM 6.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Rbbp5 in Genome Data Viewer
    Location:
    1; 1 E4
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (132477348..132508639)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (134373944..134402242)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene transmembrane and coiled-coil domains 2 Neighboring gene dual serine/threonine and tyrosine protein kinase Neighboring gene transmembrane protein 81 Neighboring gene contactin 2 Neighboring gene neurofascin Neighboring gene predicted gene, 46157

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to histone methyltransferase activity (H3-K4 specific) ISO
    Inferred from Sequence Orthology
    more info
     
    methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    histone H3-K4 methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone H3-K4 methylation ISO
    Inferred from Sequence Orthology
    more info
     
    response to estrogen ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    MLL3/4 complex ISO
    Inferred from Sequence Orthology
    more info
     
    Set1C/COMPASS complex ISO
    Inferred from Sequence Orthology
    more info
     
    histone methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    retinoblastoma-binding protein 5
    Names
    RBBP-5
    retinoblastoma binding protein 5

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357486.1NP_001344415.1  retinoblastoma-binding protein 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC107846
      Conserved Domains (3) summary
      PTZ00441
      Location:340493
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      sd00039
      Location:2964
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:30322
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_001357487.1NP_001344416.1  retinoblastoma-binding protein 5 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC107846
      Conserved Domains (3) summary
      COG2319
      Location:10194
      WD40; WD40 repeat [General function prediction only]
      PTZ00441
      Location:213366
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      sd00039
      Location:75120
      7WD40; WD40 repeat [structural motif]
    3. NM_172517.2NP_766105.2  retinoblastoma-binding protein 5 isoform 1

      See identical proteins and their annotated locations for NP_766105.2

      Status: VALIDATED

      Source sequence(s)
      AC107846, AK049247, BY193756, CV562303
      Consensus CDS
      CCDS15286.1
      UniProtKB/Swiss-Prot
      Q8BX09
      Related
      ENSMUSP00000141003.1, OTTMUSP00000068135, ENSMUST00000190997.6, OTTMUST00000125904
      Conserved Domains (3) summary
      PTZ00441
      Location:340498
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      sd00039
      Location:2964
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:30322
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      132477348..132508639
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529358.3XP_006529421.1  retinoblastoma-binding protein 5 isoform X2

      Related
      ENSMUSP00000141176.1, OTTMUSP00000068136, ENSMUST00000187505.6, OTTMUST00000125905
      Conserved Domains (3) summary
      COG2319
      Location:4282
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:3067
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:34283
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_006529357.2XP_006529420.1  retinoblastoma-binding protein 5 isoform X1

      Conserved Domains (3) summary
      PTZ00441
      Location:340493
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      sd00039
      Location:2964
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:30322
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. XM_006529359.1XP_006529422.1  retinoblastoma-binding protein 5 isoform X3

      Conserved Domains (3) summary
      COG2319
      Location:38321
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:2964
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:30322
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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