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    Dstyk dual serine/threonine and tyrosine protein kinase [ Mus musculus (house mouse) ]

    Gene ID: 213452, updated on 9-Sep-2018

    Summary

    Official Symbol
    Dstykprovided by MGI
    Official Full Name
    dual serine/threonine and tyrosine protein kinaseprovided by MGI
    Primary source
    MGI:MGI:1925064
    See related
    Ensembl:ENSMUSG00000042046 Vega:OTTMUSG00000049388
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ripk5; C820013G01; A930019K20Rik; C430014H23Rik
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 5.7), ovary adult (RPKM 5.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Dstyk in Genome Data Viewer
    Location:
    1; 1 E4
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (132417182..132466959)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (134314030..134363536)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA F730311O21 gene Neighboring gene transmembrane and coiled-coil domains 2 Neighboring gene retinoblastoma binding protein 5, histone lysine methyltransferase complex subunit Neighboring gene transmembrane protein 81 Neighboring gene contactin 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular response to fibroblast growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dual serine/threonine and tyrosine protein kinase
    Names
    dusty PK
    dusty protein kinase
    receptor interacting protein kinase 5
    receptor-interacting serine/threonine-protein kinase 5
    NP_766104.2
    XP_006529419.1
    XP_017175173.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172516.4NP_766104.2  dual serine/threonine and tyrosine protein kinase

      See identical proteins and their annotated locations for NP_766104.2

      Status: VALIDATED

      Source sequence(s)
      AK050542, AK082434, AK082904, AK083696, AK132119, BB749395, CJ110290
      Consensus CDS
      CCDS15285.1
      UniProtKB/Swiss-Prot
      Q6XUX1
      Related
      ENSMUSP00000035358.7, OTTMUSP00000068131, ENSMUST00000045110.13, OTTMUST00000125892
      Conserved Domains (2) summary
      smart00220
      Location:651895
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13975
      Location:649910
      PKc_Dusty; Catalytic domain of the Dual-specificity Protein Kinase, Dusty

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      132417182..132466959
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319684.1XP_017175173.1  dual serine/threonine and tyrosine protein kinase isoform X2

    2. XM_006529356.3XP_006529419.1  dual serine/threonine and tyrosine protein kinase isoform X1

      See identical proteins and their annotated locations for XP_006529419.1

      Conserved Domains (2) summary
      smart00220
      Location:553797
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13975
      Location:551812
      PKc_Dusty; Catalytic domain of the Dual-specificity Protein Kinase, Dusty

    RNA

    1. XR_387156.3 RNA Sequence

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