Format

Send to:

Choose Destination
    • Showing Current items.

    Tacc3 transforming, acidic coiled-coil containing protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 21335, updated on 16-Nov-2018

    Summary

    Official Symbol
    Tacc3provided by MGI
    Official Full Name
    transforming, acidic coiled-coil containing protein 3provided by MGI
    Primary source
    MGI:MGI:1341163
    See related
    Ensembl:ENSMUSG00000037313 Vega:OTTMUSG00000025055
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aint; Eric1; C86661
    Expression
    Broad expression in CNS E11.5 (RPKM 34.6), liver E14 (RPKM 25.7) and 18 other tissues See more
    Orthologs

    Genomic context

    See Tacc3 in Genome Data Viewer
    Location:
    5; 5 B2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (33658128..33672203)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (34000796..34014847)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene stem-loop binding protein Neighboring gene transmembrane protein 129 Neighboring gene fibroblast growth factor receptor 3 Neighboring gene leucine zipper-EF-hand containing transmembrane protein 1 Neighboring gene ribosomal protein S29 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    astral microtubule organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebral cortex development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cerebral cortex development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytoplasmic sequestering of transcription factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    interkinetic nuclear migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    metaphase/anaphase transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microtubule cytoskeleton organization involved in mitosis ISO
    Inferred from Sequence Orthology
    more info
     
    neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of microtubule-based process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule organizing center ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transforming acidic coiled-coil-containing protein 3
    Names
    ARNT-interacting protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040435.3NP_001035525.1  transforming acidic coiled-coil-containing protein 3 isoform 2

      See identical proteins and their annotated locations for NP_001035525.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC162898, AK145556, BB612450
      Consensus CDS
      CCDS39065.1
      UniProtKB/TrEMBL
      Q6NV52
      Related
      ENSMUSP00000110069.3, OTTMUSP00000030298, ENSMUST00000114426.9, OTTMUST00000061673
      Conserved Domains (2) summary
      pfam05010
      Location:428624
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      cl03075
      Location:426580
      GrpE; nucleotide exchange factor GrpE
    2. NM_001310541.1NP_001297470.1  transforming acidic coiled-coil-containing protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001297470.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC162898
      Consensus CDS
      CCDS80258.1
      UniProtKB/TrEMBL
      Q99LH8
      Related
      ENSMUSP00000074394.6, OTTMUSP00000030279, ENSMUST00000074849.12, OTTMUST00000061652
      Conserved Domains (2) summary
      pfam05010
      Location:435631
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      cl03075
      Location:433587
      GrpE; nucleotide exchange factor GrpE

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      33658128..33672203
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320784.1XP_017176273.1  transforming acidic coiled-coil-containing protein 3 isoform X2

    2. XM_011240716.2XP_011239018.1  transforming acidic coiled-coil-containing protein 3 isoform X4

      Conserved Domains (1) summary
      cl03075
      Location:449577
      GrpE; nucleotide exchange factor GrpE
    3. XM_006503835.3XP_006503898.1  transforming acidic coiled-coil-containing protein 3 isoform X5

      Conserved Domains (2) summary
      pfam05010
      Location:362558
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      cl03075
      Location:360514
      GrpE; nucleotide exchange factor GrpE
    4. XM_011240715.1XP_011239017.1  transforming acidic coiled-coil-containing protein 3 isoform X1

      Conserved Domains (2) summary
      pfam05010
      Location:444640
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      cl03075
      Location:442596
      GrpE; nucleotide exchange factor GrpE
    5. XM_006503832.3XP_006503895.1  transforming acidic coiled-coil-containing protein 3 isoform X3

      See identical proteins and their annotated locations for XP_006503895.1

      UniProtKB/TrEMBL
      Q99LH8
      Conserved Domains (2) summary
      pfam05010
      Location:435631
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      cl03075
      Location:433587
      GrpE; nucleotide exchange factor GrpE

    RNA

    1. XR_868281.2 RNA Sequence

    2. XR_001784660.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_011524.3: Suppressed sequence

      Description
      NM_011524.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Support Center