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    Lcor ligand dependent nuclear receptor corepressor [ Mus musculus (house mouse) ]

    Gene ID: 212391, updated on 23-Jun-2021

    Summary

    Official Symbol
    Lcorprovided by MGI
    Official Full Name
    ligand dependent nuclear receptor corepressorprovided by MGI
    Primary source
    MGI:MGI:2443930
    See related
    Ensembl:ENSMUSG00000025019
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ml; Mlr2; Gm340; mKIAA1795; 3110023F06Rik; A630025C20Rik
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 2.8), placenta adult (RPKM 2.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Lcor in Genome Data Viewer
    Location:
    19; 19 C3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (41471121..41584600)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (41482682..41596161)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (41624129..41634271)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33951 Neighboring gene developmental pluripotency associated 2 pseudogene Neighboring gene mortality factor 4 like 1B Neighboring gene microRNA 8091 Neighboring gene predicted gene, 52407 Neighboring gene slit guidance ligand 1 Neighboring gene predicted gene, 34116

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone methyltransferase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-specific protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ligand-dependent corepressor
    Names
    Mblk1-related protein-2
    mblk1-related protein 2
    transcription factor MLR2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370767.1NP_001357696.1  ligand-dependent corepressor isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC112271, AC132303
      Consensus CDS
      CCDS89392.1
      Related
      ENSMUSP00000158715.2, ENSMUST00000238398.2
      Conserved Domains (3) summary
      PTZ00441
      Location:726959
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      pfam05109
      Location:558823
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam15090
      Location:12471694
      DUF4553; Domain of unknown function (DUF4553)
    2. NM_172154.4NP_742166.1  ligand-dependent corepressor isoform 2

      See identical proteins and their annotated locations for NP_742166.1

      Status: VALIDATED

      Source sequence(s)
      AC132303
      Consensus CDS
      CCDS29810.1
      UniProtKB/Swiss-Prot
      Q6ZPI3
      UniProtKB/TrEMBL
      A4FTY7
      Related
      ENSMUSP00000126441.2, ENSMUST00000163929.2
      Conserved Domains (1) summary
      pfam05225
      Location:352395
      HTH_psq; helix-turn-helix, Psq domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      41471121..41584600
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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