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    Inpp5a inositol polyphosphate-5-phosphatase A [ Mus musculus (house mouse) ]

    Gene ID: 212111, updated on 6-Sep-2021

    Summary

    Official Symbol
    Inpp5aprovided by MGI
    Official Full Name
    inositol polyphosphate-5-phosphatase Aprovided by MGI
    Primary source
    MGI:MGI:2686961
    See related
    Ensembl:ENSMUSG00000025477
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Ubiquitous expression in heart adult (RPKM 45.3), cerebellum adult (RPKM 37.4) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Inpp5a in Genome Data Viewer
    Location:
    7; 7 F4
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (138969025..139159568)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (139389074..139579652)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (146575008..146765551)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32571 Neighboring gene predicted gene, 46004 Neighboring gene predicted gene, 53346 Neighboring gene VISTA enhancer mm1683 Neighboring gene glycosylated lysosomal membrane protein pseudogene Neighboring gene predicted gene, 33031 Neighboring gene NK6 homeobox 2 Neighboring gene cilia and flagella associated protein 46 Neighboring gene NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables PH domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables inositol-1,4,5-trisphosphate 5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables inositol-polyphosphate 5-phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables inositol-polyphosphate 5-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within inositol phosphate dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphatidylinositol dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    inositol polyphosphate-5-phosphatase A
    Names
    5PTase
    type I inositol 1,4,5-trisphosphate 5-phosphatase
    NP_001120835.1
    NP_001342091.1
    NP_898967.2
    XP_017177585.1
    XP_030098193.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127363.1NP_001120835.1  inositol polyphosphate-5-phosphatase A isoform a

      See identical proteins and their annotated locations for NP_001120835.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      BC056341
      Consensus CDS
      CCDS52428.1
      UniProtKB/TrEMBL
      Q7TNC9
      Related
      ENSMUSP00000101704.2, ENSMUST00000106098.8
      Conserved Domains (1) summary
      cd09092
      Location:10394
      INPP5A; Type I inositol polyphosphate 5-phosphatase I
    2. NM_001355162.1NP_001342091.1  inositol polyphosphate-5-phosphatase A isoform c

      Status: VALIDATED

      Source sequence(s)
      AC112670, AC118735
      Consensus CDS
      CCDS90348.1
      Related
      ENSMUSP00000095589.3, ENSMUST00000097975.3
      Conserved Domains (1) summary
      cd09092
      Location:34402
      INPP5A; Type I inositol polyphosphate 5-phosphatase I
    3. NM_183144.3NP_898967.2  inositol polyphosphate-5-phosphatase A isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region that results in a frameshift compared to variant 1. The resulting protein (isoform b) is longer and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      BC056341
      Consensus CDS
      CCDS21954.1
      UniProtKB/TrEMBL
      E9QAS7, Q7TNC9
      Related
      ENSMUSP00000026550.8, ENSMUST00000026550.14
      Conserved Domains (1) summary
      cd09092
      Location:10394
      INPP5A; Type I inositol polyphosphate 5-phosphatase I

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      138969025..139159568
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242333.2XP_030098193.1  inositol polyphosphate-5-phosphatase A isoform X2

      Conserved Domains (1) summary
      cd09092
      Location:1346
      INPP5A; Type I inositol polyphosphate 5-phosphatase I
    2. XM_017322096.2XP_017177585.1  inositol polyphosphate-5-phosphatase A isoform X1

      Conserved Domains (1) summary
      cd09092
      Location:24394
      INPP5A; Type I inositol polyphosphate 5-phosphatase I
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