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    Pde12 phosphodiesterase 12 [ Mus musculus (house mouse) ]

    Gene ID: 211948, updated on 31-Jan-2019

    Summary

    Official Symbol
    Pde12provided by MGI
    Official Full Name
    phosphodiesterase 12provided by MGI
    Primary source
    MGI:MGI:2443226
    See related
    Ensembl:ENSMUSG00000043702
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2'-PDE; E430028B21Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 10.0), ovary adult (RPKM 8.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Pde12 in Genome Data Viewer
    Location:
    14; 14 A3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (26664117..26669846, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (27483603..27489332, complement)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene DENN/MADD domain containing 6A Neighboring gene ADP-ribosylation factor 4 Neighboring gene microRNA 7672 Neighboring gene dynein, axonemal, heavy chain 12 Neighboring gene predicted gene, 34415 Neighboring gene ankyrin repeat and SOCS box-containing 14

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    3'-5'-exoribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    poly(A)-specific ribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    RNA phosphodiester bond hydrolysis, exonucleolytic ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to dsRNA ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to interferon-alpha ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to interferon-gamma ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of oxidative phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
    Inferred from Sequence Orthology
    more info
     
    nucleic acid phosphodiester bond hydrolysis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitochondrial mRNA stability ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 

    General protein information

    Preferred Names
    2',5'-phosphodiesterase 12
    Names
    2'-phosphodiesterase
    2-PDE
    mitochondrial deadenylase
    NP_848783.3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178668.3NP_848783.3  2',5'-phosphodiesterase 12

      See identical proteins and their annotated locations for NP_848783.3

      Status: PROVISIONAL

      Source sequence(s)
      BC064450
      Consensus CDS
      CCDS26882.1
      UniProtKB/Swiss-Prot
      Q3TIU4
      Related
      ENSMUSP00000059666.9, ENSMUST00000052932.9
      Conserved Domains (1) summary
      cl00490
      Location:298607
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      26664117..26669846 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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