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    Asap2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 [ Mus musculus (house mouse) ]

    Gene ID: 211914, updated on 19-Feb-2019

    Summary

    Official Symbol
    Asap2provided by MGI
    Official Full Name
    ArfGAP with SH3 domain, ankyrin repeat and PH domain 2provided by MGI
    Primary source
    MGI:MGI:2685438
    See related
    Ensembl:ENSMUSG00000052632
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PAP; PAG3; Ddef2; Gm592; Gm1523; 6530401G17Rik
    Expression
    Ubiquitous expression in CNS E14 (RPKM 10.8), bladder adult (RPKM 10.1) and 27 other tissues See more
    Orthologs

    Genomic context

    See Asap2 in Genome Data Viewer
    Location:
    12; 12 A1.2-A1.3
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (21111713..21270171)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (21117617..21276032)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 46306 Neighboring gene predicted gene 5977 Neighboring gene predicted gene, 40855 Neighboring gene integrin beta 1 binding protein 1 Neighboring gene cleavage and polyadenylation specificity factor 3 Neighboring gene a disintegrin and metallopeptidase domain 17 Neighboring gene isoamyl acetate-hydrolyzing esterase 1 homolog

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Pathways from BioSystems

    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC90837

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular_component ND
    No biological Data available
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2
    Names
    development and differentiation enhancing factor 2
    paxillin-associated protein with ARF GAP activity 3
    pyk2 C-terminus-associated protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004364.2NP_001004364.2  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site and lacks two alternate in-frame exons, compared to variant 3. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform c.
      Source sequence(s)
      BC080847, BC096022
      Consensus CDS
      CCDS49036.1
      UniProtKB/Swiss-Prot
      Q7SIG6
      UniProtKB/TrEMBL
      D3YX85
      Related
      ENSMUSP00000054631.9, ENSMUST00000050990.9
      Conserved Domains (8) summary
      cd11966
      Location:897952
      SH3_ASAP2; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2
      cd00204
      Location:579673
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:297403
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      pfam00169
      Location:306393
      PH; PH domain
      pfam01412
      Location:421538
      ArfGap; Putative GTPase activating protein for Arf
      pfam13857
      Location:607661
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:586618
      ANK; ANK repeat [structural motif]
      cl12013
      Location:34248
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. NM_001098168.1NP_001091637.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform a

      See identical proteins and their annotated locations for NP_001091637.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice site and lacks an alternate in-frame exon in the 3' coding region, compared to variant 3. The resulting isoform (a) has the same N- and C-termini but is shorter compared to isoform c.
      Source sequence(s)
      BC080847, BC096022
      Consensus CDS
      CCDS56832.1
      UniProtKB/Swiss-Prot
      Q7SIG6
      Related
      ENSMUSP00000099098.4, ENSMUST00000101562.10
      Conserved Domains (8) summary
      cd11966
      Location:900955
      SH3_ASAP2; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2
      cd00204
      Location:582676
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:300406
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      pfam00169
      Location:309396
      PH; PH domain
      pfam01412
      Location:424541
      ArfGap; Putative GTPase activating protein for Arf
      pfam13857
      Location:610664
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:589621
      ANK; ANK repeat [structural motif]
      cl12013
      Location:34248
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    3. NM_001135192.1NP_001128664.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
      Source sequence(s)
      AC156032, AK147622, BC096022, CD351639
      Consensus CDS
      CCDS49037.1
      UniProtKB/Swiss-Prot
      Q7SIG6
      UniProtKB/TrEMBL
      E9PX52, Q3UH27
      Related
      ENSMUSP00000063217.8, ENSMUST00000064595.14
      Conserved Domains (8) summary
      cd07642
      Location:34248
      BAR_ASAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 2
      cd11966
      Location:942997
      SH3_ASAP2; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2
      cd00204
      Location:579673
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:297403
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      pfam00169
      Location:306393
      PH; PH domain
      pfam01412
      Location:421538
      ArfGap; Putative GTPase activating protein for Arf
      pfam13857
      Location:607661
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:586618
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      21111713..21270171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515047.1XP_006515110.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1

      Conserved Domains (8) summary
      cd07642
      Location:34248
      BAR_ASAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 2
      cd11966
      Location:9451000
      SH3_ASAP2; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2
      cd00204
      Location:582676
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:300406
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      pfam00169
      Location:309396
      PH; PH domain
      pfam01412
      Location:424541
      ArfGap; Putative GTPase activating protein for Arf
      pfam13857
      Location:610664
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:589621
      ANK; ANK repeat [structural motif]
    2. XM_006515048.1XP_006515111.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X2

      Conserved Domains (8) summary
      cd07642
      Location:34248
      BAR_ASAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 2
      cd11966
      Location:942997
      SH3_ASAP2; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2
      cd00204
      Location:579673
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:297403
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      pfam00169
      Location:306393
      PH; PH domain
      pfam01412
      Location:421538
      ArfGap; Putative GTPase activating protein for Arf
      pfam13857
      Location:607661
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:586618
      ANK; ANK repeat [structural motif]
    3. XM_006515050.3XP_006515113.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X3

      Conserved Domains (8) summary
      cd11966
      Location:827882
      SH3_ASAP2; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2
      cd00204
      Location:464558
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:182288
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      pfam00169
      Location:191278
      PH; PH domain
      pfam01412
      Location:306423
      ArfGap; Putative GTPase activating protein for Arf
      pfam13857
      Location:492546
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:471503
      ANK; ANK repeat [structural motif]
      cl12013
      Location:1130
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RNA

    1. XR_001780443.1 RNA Sequence

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