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    Depdc7 DEP domain containing 7 [ Mus musculus (house mouse) ]

    Gene ID: 211896, updated on 27-Feb-2024


    Official Symbol
    Depdc7provided by MGI
    Official Full Name
    DEP domain containing 7provided by MGI
    Primary source
    See related
    Ensembl:ENSMUSG00000027173 AllianceGenome:MGI:2139258
    Gene type
    protein coding
    RefSeq status
    Mus musculus
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Predicted to be involved in intracellular signal transduction. Is expressed in liver and metanephros. Orthologous to human DEPDC7 (DEP domain containing 7). [provided by Alliance of Genome Resources, Apr 2022]
    Broad expression in placenta adult (RPKM 12.7), liver adult (RPKM 12.4) and 15 other tissues See more
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    Genomic context

    See Depdc7 in Genome Data Viewer
    2 E2; 2 54.91 cM
    Exon count:
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (104552129..104573202, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (104721784..104742857, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene t-complex 11 like 1 Neighboring gene predicted gene 6306 Neighboring gene peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1, retrogene 1 Neighboring gene STARR-seq mESC enhancer starr_05294 Neighboring gene glutamine and serine rich 1 Neighboring gene RIKEN cDNA 2310047K21 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:104657358-104657511 Neighboring gene predicted gene, 39898

    Genomic regions, transcripts, and products


    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a



    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (3) 

    General gene information


    Clone Names

    • MGC19163

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info

    General protein information

    Preferred Names
    DEP domain-containing protein 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144804.2NP_659053.1  DEP domain-containing protein 7

      See identical proteins and their annotated locations for NP_659053.1

      Status: VALIDATED

      Source sequence(s)
      AK134830, DV647572
      Consensus CDS
      Q3TN66, Q3UNR5, Q91WS7
      ENSMUSP00000028595.8, ENSMUST00000028595.8
      Conserved Domains (2) summary
      RhoGAP_BRCC3-like; RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain ...
      DEP_DEPDC4; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a DEP domain containing protein of unknown function.

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J


    1. NC_000068.8 Reference GRCm39 C57BL/6J

      104552129..104573202 complement
      GenBank, FASTA, Sequence Viewer (Graphics)