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    Arfgef1 ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) [ Mus musculus (house mouse) ]

    Gene ID: 211673, updated on 31-Jan-2019

    Summary

    Official Symbol
    Arfgef1provided by MGI
    Official Full Name
    ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)provided by MGI
    Primary source
    MGI:MGI:2442988
    See related
    Ensembl:ENSMUSG00000067851
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BIG1; P200; ARFGEP1; D130059B05Rik; D730028O18Rik
    Expression
    Ubiquitous expression in bladder adult (RPKM 12.0), placenta adult (RPKM 10.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Arfgef1 in Genome Data Viewer
    Location:
    1; 1 A2
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (10137507..10232670, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (10127588..10222751, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 42 Neighboring gene COP9 signalosome subunit 5 Neighboring gene centrosome and spindle pole associated protein 1 Neighboring gene carboxypeptidase A6 Neighboring gene heat shock protein 8 pseudogene Neighboring gene predicted gene 15603

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ARF guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    myosin binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase A regulatory subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Golgi organization ISO
    Inferred from Sequence Orthology
    more info
     
    endomembrane system organization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein glycosylation in Golgi ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of establishment of cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    small nuclear ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     
    trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    brefeldin A-inhibited guanine nucleotide-exchange protein 1
    Names
    ADP-ribosylation factor guanine nucleotide-exchange factor 1
    brefeldin A-inhibited GEP 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102430.1NP_001095900.1  brefeldin A-inhibited guanine nucleotide-exchange protein 1

      See identical proteins and their annotated locations for NP_001095900.1

      Status: PROVISIONAL

      Source sequence(s)
      AC102462, AC159972
      Consensus CDS
      CCDS35512.1
      UniProtKB/Swiss-Prot
      G3X9K3
      Related
      ENSMUSP00000085986.4, ENSMUST00000088615.10
      Conserved Domains (5) summary
      PLN03076
      Location:151763
      PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
      pfam01369
      Location:695879
      Sec7; Sec7 domain
      pfam09324
      Location:12171298
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:416570
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16213
      Location:29210
      DCB; Dimerization and cyclophilin-binding domain of Mon2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      10137507..10232670 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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