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    Ap1ar adaptor-related protein complex 1 associated regulatory protein [ Mus musculus (house mouse) ]

    Gene ID: 211556, updated on 26-Sep-2022

    Summary

    Official Symbol
    Ap1arprovided by MGI
    Official Full Name
    adaptor-related protein complex 1 associated regulatory proteinprovided by MGI
    Primary source
    MGI:MGI:2384822
    See related
    Ensembl:ENSMUSG00000074238 AllianceGenome:MGI:2384822
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gadkin
    Summary
    Predicted to enable AP-1 adaptor complex binding activity; Arp2/3 complex binding activity; and kinesin binding activity. Acts upstream of or within several processes, including negative regulation of cell motility; negative regulation of substrate adhesion-dependent cell spreading; and regulation of Arp2/3 complex-mediated actin nucleation. Located in endosome. Is expressed in several structures, including cardiovascular system; genitourinary system; gut; integumental system; and nervous system. Orthologous to human AP1AR (adaptor related protein complex 1 associated regulatory protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 18.9), colon adult (RPKM 18.9) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ap1ar in Genome Data Viewer
    Location:
    3; 3 G2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (127600656..127631172, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (127807007..127837523, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene alpha-kinase 1 Neighboring gene VISTA enhancer mm1549 Neighboring gene TRAF-interacting protein with forkhead-associated domain Neighboring gene predicted gene 43653 Neighboring gene predicted gene, 35585 Neighboring gene family with sequence similarity 241, member A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (2) 

    General gene information

    Markers

    Homology

    Clone Names

    • MGC7434

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables AP-1 adaptor complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables AP-1 adaptor complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables Arp2/3 complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinesin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in transport vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    AP-1 complex-associated regulatory protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346718.3NP_001333647.1  AP-1 complex-associated regulatory protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC163391
      Consensus CDS
      CCDS84673.1
      UniProtKB/TrEMBL
      A0A0G2JG85, A0A8C6I998
      Related
      ENSMUSP00000143466.2, ENSMUST00000200409.5
    2. NM_001411484.1NP_001398413.1  AP-1 complex-associated regulatory protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC163391
    3. NM_001411486.1NP_001398415.1  AP-1 complex-associated regulatory protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC163391
    4. NM_001411487.1NP_001398416.1  AP-1 complex-associated regulatory protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC163391
    5. NM_001411488.1NP_001398417.1  AP-1 complex-associated regulatory protein isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC163391
    6. NM_001411489.1NP_001398418.1  AP-1 complex-associated regulatory protein isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC163391
    7. NM_001411490.1NP_001398419.1  AP-1 complex-associated regulatory protein isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC163391
    8. NM_145964.4NP_666076.2  AP-1 complex-associated regulatory protein isoform 1

      See identical proteins and their annotated locations for NP_666076.2

      Status: VALIDATED

      Source sequence(s)
      AC163391
      Consensus CDS
      CCDS38629.1
      UniProtKB/TrEMBL
      A0A8C6IBB7, E9PYF7
      Related
      ENSMUSP00000059669.7, ENSMUST00000051737.8
      Conserved Domains (1) summary
      pfam15745
      Location:24298
      AP1AR; AP-1 complex-associated regulatory protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      127600656..127631172 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252524.2XP_030108384.1  AP-1 complex-associated regulatory protein isoform X7

      Conserved Domains (1) summary
      pfam15745
      Location:39277
      AP1AR; AP-1 complex-associated regulatory protein
    2. XM_006501244.4XP_006501307.1  AP-1 complex-associated regulatory protein isoform X5

      Conserved Domains (1) summary
      pfam15745
      Location:39310
      AP1AR; AP-1 complex-associated regulatory protein
    3. XM_006501241.4XP_006501304.1  AP-1 complex-associated regulatory protein isoform X2

      Conserved Domains (1) summary
      pfam15745
      Location:74345
      AP1AR; AP-1 complex-associated regulatory protein
    4. XM_006501242.3XP_006501305.1  AP-1 complex-associated regulatory protein isoform X3

      Conserved Domains (1) summary
      pfam15745
      Location:99337
      AP1AR; AP-1 complex-associated regulatory protein
    5. XM_006501240.3XP_006501303.1  AP-1 complex-associated regulatory protein isoform X1

      Conserved Domains (1) summary
      pfam15745
      Location:99370
      AP1AR; AP-1 complex-associated regulatory protein
    6. XM_030252526.2XP_030108386.1  AP-1 complex-associated regulatory protein isoform X9

      Conserved Domains (1) summary
      pfam15745
      Location:2207
      AP1AR; AP-1 complex-associated regulatory protein
    7. XM_030252525.2XP_030108385.1  AP-1 complex-associated regulatory protein isoform X8

      Conserved Domains (1) summary
      pfam15745
      Location:2240
      AP1AR; AP-1 complex-associated regulatory protein
    8. XM_006501245.3XP_006501308.1  AP-1 complex-associated regulatory protein isoform X6

      Conserved Domains (1) summary
      pfam15745
      Location:18289
      AP1AR; AP-1 complex-associated regulatory protein
    9. XM_006501243.3XP_006501306.1  AP-1 complex-associated regulatory protein isoform X4

      Conserved Domains (1) summary
      pfam15745
      Location:53324
      AP1AR; AP-1 complex-associated regulatory protein