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    Efhb EF hand domain family, member B [ Mus musculus (house mouse) ]

    Gene ID: 211482, updated on 23-Jun-2021

    Summary

    Official Symbol
    Efhbprovided by MGI
    Official Full Name
    EF hand domain family, member Bprovided by MGI
    Primary source
    MGI:MGI:3045296
    See related
    Ensembl:ENSMUSG00000023931
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4921525D22Rik
    Expression
    Biased expression in testis adult (RPKM 6.8) and whole brain E14.5 (RPKM 0.2) See more
    Orthologs
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    Genomic context

    See Efhb in Genome Data Viewer
    Location:
    17; 17 C
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (53705077..53770362, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (53398044..53463334, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (53538214..53602646, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29770 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 pseudogene Neighboring gene predicted gene, 51426 Neighboring gene tumor protein, translationally-controlled, pseudogene 7 Neighboring gene RAB5A, member RAS oncogene family Neighboring gene protein phosphatase 2C-like domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion sensor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of store-operated calcium entry ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    EF-hand domain-containing family member B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172497.3NP_766085.2  EF-hand domain-containing family member B

      See identical proteins and their annotated locations for NP_766085.2

      Status: VALIDATED

      Source sequence(s)
      AK029550, BC132103
      Consensus CDS
      CCDS37652.1
      UniProtKB/Swiss-Prot
      Q8CDU5
      Related
      ENSMUSP00000024725.5, ENSMUST00000024725.5
      Conserved Domains (2) summary
      cd00051
      Location:586646
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:586646
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      53705077..53770362 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246352.3XP_011244654.1  EF-hand domain-containing family member B isoform X2

      See identical proteins and their annotated locations for XP_011244654.1

      Conserved Domains (1) summary
      pfam13499
      Location:166229
      EF-hand_7; EF-hand domain pair
    2. XM_011246351.3XP_011244653.1  EF-hand domain-containing family member B isoform X2

      See identical proteins and their annotated locations for XP_011244653.1

      Conserved Domains (1) summary
      pfam13499
      Location:166229
      EF-hand_7; EF-hand domain pair
    3. XM_017317379.2XP_017172868.1  EF-hand domain-containing family member B isoform X3

      Conserved Domains (1) summary
      pfam13499
      Location:103166
      EF-hand_7; EF-hand domain pair
    4. XM_006523983.4XP_006524046.1  EF-hand domain-containing family member B isoform X1

      Conserved Domains (1) summary
      pfam13499
      Location:583638
      EF-hand_7; EF-hand domain pair

    RNA

    1. XR_003952101.2 RNA Sequence

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