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    Sepsecs Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase [ Mus musculus (house mouse) ]

    Gene ID: 211006, updated on 16-Oct-2021

    Summary

    Official Symbol
    Sepsecsprovided by MGI
    Official Full Name
    Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthaseprovided by MGI
    Primary source
    MGI:MGI:1098791
    See related
    Ensembl:ENSMUSG00000029173
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SLA; SecS; AA986712; D5Ertd135e
    Expression
    Ubiquitous expression in placenta adult (RPKM 4.8), liver adult (RPKM 4.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Sepsecs in Genome Data Viewer
    Location:
    5 C1; 5 28.44 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (52797431..52827104, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (52640089..52669764, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (53034646..53060940, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 8030423F21 gene Neighboring gene predicted gene, 30178 Neighboring gene phosphatidylinositol 4-kinase type 2 beta Neighboring gene zinc finger, CCHC domain containing 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • 9130208G10

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoseryl-selenocysteinyl-tRNA selenium transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables selenotransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables tRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in selenocysteine incorporation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in selenocysteine incorporation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in selenocysteinyl-tRNA(Sec) biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    O-phosphoseryl-tRNA(Sec) selenium transferase
    Names
    UGA suppressor tRNA-associated protein
    selenocysteinyl-tRNA(Sec) synthase
    NP_001350392.1
    NP_766078.1
    XP_006503890.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363463.1NP_001350392.1  O-phosphoseryl-tRNA(Sec) selenium transferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK153792
      Conserved Domains (1) summary
      cl18945
      Location:1317
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
    2. NM_172490.4NP_766078.1  O-phosphoseryl-tRNA(Sec) selenium transferase isoform 1

      See identical proteins and their annotated locations for NP_766078.1

      Status: VALIDATED

      Source sequence(s)
      AC120128
      Consensus CDS
      CCDS19286.1
      UniProtKB/Swiss-Prot
      Q6P6M7
      Related
      ENSMUSP00000031069.7, ENSMUST00000031069.13
      Conserved Domains (1) summary
      TIGR03531
      Location:13458
      selenium_SpcS; O-phosphoseryl-tRNA(Sec) selenium transferase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      52797431..52827104 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503827.5XP_006503890.1  O-phosphoseryl-tRNA(Sec) selenium transferase isoform X1

      Conserved Domains (1) summary
      cl18945
      Location:13268
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
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