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    Lpcat1 lysophosphatidylcholine acyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 210992, updated on 23-Jun-2021

    Summary

    Official Symbol
    Lpcat1provided by MGI
    Official Full Name
    lysophosphatidylcholine acyltransferase 1provided by MGI
    Primary source
    MGI:MGI:2384812
    See related
    Ensembl:ENSMUSG00000021608
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LP; Ayt; rd1; rd11; Aytl2; LPCAT; C87117; LPCAT-1; mLPCAT1; BB137372; BC005662; lysoPAFAT; 2900035H07Rik
    Expression
    Broad expression in lung adult (RPKM 143.7), liver E14.5 (RPKM 30.7) and 16 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Lpcat1 in Genome Data Viewer
    Location:
    13; 13 C1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (73615332..73664539)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (73467231..73516420)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (73604831..73651986)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L36 Neighboring gene ephemeron, early developmental lncRNA Neighboring gene solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Neighboring gene CLPTM1-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC8148

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    lysophosphatidylcholine acyltransferase 1
    Names
    1-acylglycerol-3-phosphate O-acyltransferase
    1-acylglycerophosphocholine O-acyltransferase
    1-alkenylglycerophosphocholine O-acyltransferase
    1-alkylglycerophosphocholine O-acetyltransferase
    LPC acyltransferase 1
    acetyl-CoA:lyso-PAF acetyltransferase
    acetyl-CoA:lyso-platelet-activating factor acetyltransferase
    acyltransferase-like 2
    lyso-PAF acetyltransferase
    lysoPC acyltransferase 1
    NP_001355610.1
    NP_001355611.1
    NP_663351.3
    XP_006517252.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368681.1NP_001355610.1  lysophosphatidylcholine acyltransferase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154547
      Conserved Domains (3) summary
      cd07991
      Location:1212
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
      COG5126
      Location:276375
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam13833
      Location:330380
      EF-hand_8; EF-hand domain pair
    2. NM_001368682.1NP_001355611.1  lysophosphatidylcholine acyltransferase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154547, AK046507
      Conserved Domains (3) summary
      cd07991
      Location:1111
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
      COG5126
      Location:175274
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam13833
      Location:229279
      EF-hand_8; EF-hand domain pair
    3. NM_145376.6NP_663351.3  lysophosphatidylcholine acyltransferase 1 isoform 1

      See identical proteins and their annotated locations for NP_663351.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC154547
      Consensus CDS
      CCDS36726.1
      UniProtKB/Swiss-Prot
      Q3TFD2
      Related
      ENSMUSP00000022099.9, ENSMUST00000022099.15
      Conserved Domains (5) summary
      cd07991
      Location:103314
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
      COG0204
      Location:59242
      PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]
      pfam13499
      Location:421479
      EF-hand_7; EF-hand domain pair
      pfam13833
      Location:432483
      EF-hand_8; EF-hand domain pair
      cl08302
      Location:384437
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      73615332..73664539
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517189.4XP_006517252.1  lysophosphatidylcholine acyltransferase 1 isoform X1

      Conserved Domains (3) summary
      COG5126
      Location:127226
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam13833
      Location:181231
      EF-hand_8; EF-hand domain pair
      cl17185
      Location:263
      LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
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