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    Brcc3 BRCA1/BRCA2-containing complex, subunit 3 [ Mus musculus (house mouse) ]

    Gene ID: 210766, updated on 31-Jan-2019

    Summary

    Official Symbol
    Brcc3provided by MGI
    Official Full Name
    BRCA1/BRCA2-containing complex, subunit 3provided by MGI
    Primary source
    MGI:MGI:2389572
    See related
    Ensembl:ENSMUSG00000031201
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C6.1A
    Expression
    Broad expression in CNS E11.5 (RPKM 5.2), liver E14 (RPKM 5.1) and 24 other tissues See more
    Orthologs

    Genomic context

    See Brcc3 in Genome Data Viewer
    Location:
    X; X A7.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (75416623..75455702)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (72661967..72701040)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene coagulation factor VIII Neighboring gene FUN14 domain containing 2 Neighboring gene C-x(9)-C motif containing 4 Neighboring gene mature T cell proliferation 1 Neighboring gene zinc finger and SCAN domain containing 12 pseudogene Neighboring gene non-histone chromosomal protein HMG-14 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC29148

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enzyme regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metallopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity ISO
    Inferred from Sequence Orthology
    more info
     
    thiol-dependent ubiquitinyl hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    thiol-dependent ubiquitinyl hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    histone H2A K63-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone H2A K63-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    protein K63-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein K63-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    response to X-ray ISO
    Inferred from Sequence Orthology
    more info
     
    response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction involved in G2 DNA damage checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    BRCA1-A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    BRCA1-A complex ISO
    Inferred from Sequence Orthology
    more info
     
    BRISC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    BRISC complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    lys-63-specific deubiquitinase BRCC36
    Names
    6.1A protein
    BRCA1-A complex subunit BRCC36
    BRCA1/BRCA2-containing complex subunit 36
    BRISC complex subunit BRCC36
    NP_001159929.1
    NP_001159931.1
    NP_666068.1
    XP_011245856.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166457.1NP_001159929.1  lys-63-specific deubiquitinase BRCC36

      See identical proteins and their annotated locations for NP_001159929.1

      Status: VALIDATED

      Source sequence(s)
      AK149844, AL671860, BC048179
      Consensus CDS
      CCDS41031.1
      UniProtKB/Swiss-Prot
      P46737
      Related
      ENSMUSP00000033544.7, ENSMUST00000033544.13
      Conserved Domains (1) summary
      cd08068
      Location:13267
      MPN_BRCC36; Mov34/MPN/PAD-1 family: BRCC36, a subunit of BRCA1-A complex
    2. NM_001166459.1NP_001159931.1  lys-63-specific deubiquitinase BRCC36

      See identical proteins and their annotated locations for NP_001159931.1

      Status: VALIDATED

      Source sequence(s)
      AK011876, AL671860, CD774860
      Consensus CDS
      CCDS41031.1
      UniProtKB/Swiss-Prot
      P46737
      Conserved Domains (1) summary
      cd08068
      Location:13267
      MPN_BRCC36; Mov34/MPN/PAD-1 family: BRCC36, a subunit of BRCA1-A complex
    3. NM_001358736.1NP_001345665.1  lys-63-specific deubiquitinase BRCC36

      Status: VALIDATED

      Source sequence(s)
      AL671860, CD774860
      Conserved Domains (1) summary
      cd08068
      Location:13267
      MPN_BRCC36; Mov34/MPN/PAD-1 family: BRCC36, a subunit of BRCA1-A complex
    4. NM_001358737.1NP_001345666.1  lys-63-specific deubiquitinase BRCC36

      Status: VALIDATED

      Source sequence(s)
      AL671860, BC048179
      Conserved Domains (1) summary
      cd08068
      Location:13267
      MPN_BRCC36; Mov34/MPN/PAD-1 family: BRCC36, a subunit of BRCA1-A complex
    5. NM_145956.4NP_666068.1  lys-63-specific deubiquitinase BRCC36

      See identical proteins and their annotated locations for NP_666068.1

      Status: VALIDATED

      Source sequence(s)
      AK030736, AL671860, BC048179
      Consensus CDS
      CCDS41031.1
      UniProtKB/Swiss-Prot
      P46737
      Related
      ENSMUSP00000109708.1, ENSMUST00000114074.7
      Conserved Domains (1) summary
      cd08068
      Location:13267
      MPN_BRCC36; Mov34/MPN/PAD-1 family: BRCC36, a subunit of BRCA1-A complex

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      75416623..75455702
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247554.2XP_011245856.1  lys-63-specific deubiquitinase BRCC36 isoform X1

      UniProtKB/Swiss-Prot
      P46737
      Conserved Domains (1) summary
      cd08068
      Location:13267
      MPN_BRCC36; Mov34/MPN/PAD-1 family: BRCC36, a subunit of BRCA1-A complex
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