Format

Send to:

Choose Destination
    • Showing Current items.

    Brcc3 BRCA1/BRCA2-containing complex, subunit 3 [ Mus musculus (house mouse) ]

    Gene ID: 210766, updated on 5-Sep-2021

    Summary

    Official Symbol
    Brcc3provided by MGI
    Official Full Name
    BRCA1/BRCA2-containing complex, subunit 3provided by MGI
    Primary source
    MGI:MGI:2389572
    See related
    Ensembl:ENSMUSG00000031201
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C6.1; C6.1A
    Expression
    Broad expression in CNS E11.5 (RPKM 5.2), liver E14 (RPKM 5.1) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Brcc3 in Genome Data Viewer
    Location:
    X; X A7.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (74460234..74499307)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (75416628..75455702)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (72661967..72701040)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene coagulation factor VIII Neighboring gene FUN14 domain containing 2 Neighboring gene C-x(9)-C motif containing 4 Neighboring gene mature T cell proliferation 1 Neighboring gene zinc finger and SCAN domain containing 12 pseudogene Neighboring gene non-histone chromosomal protein HMG-14 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC29148

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables isopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metallopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables thiol-dependent deubiquitinase IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables thiol-dependent deubiquitinase ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H2A K63-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone H2A K63-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic G2 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K63-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to X-ray ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of BRCA1-A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of BRCA1-A complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of BRISC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of BRISC complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    part_of nuclear ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    lys-63-specific deubiquitinase BRCC36
    Names
    6.1A protein
    BRCA1-A complex subunit BRCC36
    BRCA1/BRCA2-containing complex subunit 36
    BRISC complex subunit BRCC36
    NP_001159929.1
    NP_001159931.1
    NP_001345665.1
    NP_001345666.1
    NP_666068.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166457.1NP_001159929.1  lys-63-specific deubiquitinase BRCC36

      See identical proteins and their annotated locations for NP_001159929.1

      Status: VALIDATED

      Source sequence(s)
      AK149844, AL671860, BC048179
      Consensus CDS
      CCDS41031.1
      UniProtKB/Swiss-Prot
      P46737
      Related
      ENSMUSP00000033544.8, ENSMUST00000033544.14
      Conserved Domains (1) summary
      cd08068
      Location:13267
      MPN_BRCC36; Mov34/MPN/PAD-1 family: BRCC36, a subunit of BRCA1-A complex
    2. NM_001166459.1NP_001159931.1  lys-63-specific deubiquitinase BRCC36

      See identical proteins and their annotated locations for NP_001159931.1

      Status: VALIDATED

      Source sequence(s)
      AK011876, AL671860, CD774860
      Consensus CDS
      CCDS41031.1
      UniProtKB/Swiss-Prot
      P46737
      Conserved Domains (1) summary
      cd08068
      Location:13267
      MPN_BRCC36; Mov34/MPN/PAD-1 family: BRCC36, a subunit of BRCA1-A complex
    3. NM_001358736.1NP_001345665.1  lys-63-specific deubiquitinase BRCC36

      Status: VALIDATED

      Source sequence(s)
      AL671860, CD774860
      Consensus CDS
      CCDS41031.1
      Conserved Domains (1) summary
      cd08068
      Location:13267
      MPN_BRCC36; Mov34/MPN/PAD-1 family: BRCC36, a subunit of BRCA1-A complex
    4. NM_001358737.1NP_001345666.1  lys-63-specific deubiquitinase BRCC36

      Status: VALIDATED

      Source sequence(s)
      AL671860, BC048179
      Consensus CDS
      CCDS41031.1
      Related
      ENSMUSP00000109708.2, ENSMUST00000114074.8
      Conserved Domains (1) summary
      cd08068
      Location:13267
      MPN_BRCC36; Mov34/MPN/PAD-1 family: BRCC36, a subunit of BRCA1-A complex
    5. NM_145956.4NP_666068.1  lys-63-specific deubiquitinase BRCC36

      See identical proteins and their annotated locations for NP_666068.1

      Status: VALIDATED

      Source sequence(s)
      AK030736, AL671860, BC048179
      Consensus CDS
      CCDS41031.1
      UniProtKB/Swiss-Prot
      P46737
      Conserved Domains (1) summary
      cd08068
      Location:13267
      MPN_BRCC36; Mov34/MPN/PAD-1 family: BRCC36, a subunit of BRCA1-A complex

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      74460234..74499307
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center