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    Tent4a terminal nucleotidyltransferase 4A [ Mus musculus (house mouse) ]

    Gene ID: 210106, updated on 2-Oct-2018

    Summary

    Official Symbol
    Tent4aprovided by MGI
    Official Full Name
    terminal nucleotidyltransferase 4Aprovided by MGI
    Primary source
    MGI:MGI:2682295
    See related
    Ensembl:ENSMUSG00000034575 Vega:OTTMUSG00000032573
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    POLK; Pols; TRF4; LAK-1; Papd7; TRF4-1
    Expression
    Ubiquitous expression in ovary adult (RPKM 10.5), adrenal adult (RPKM 9.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Tent4a in Genome Data Viewer
    Location:
    13 B3; 13 35.55 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (69497952..69534236, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (69636837..69672742, complement)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 35514 Neighboring gene RIKEN cDNA A930018O16 gene Neighboring gene RIKEN cDNA A530095I07 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    • RNA degradation, organism-specific biosystem (from KEGG)
      RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
    • RNA degradation, conserved biosystem (from KEGG)
      RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
    • TRAMP complex, organism-specific biosystem (from KEGG)
      TRAMP complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
    • TRAMP complex, conserved biosystem (from KEGG)
      TRAMP complex, conserved biosystemStructural complex; Genetic information processing; RNA processing

    General gene information

    Markers

    Homology

    Clone Names

    • MGC69673

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    polynucleotide adenylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    histone mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    snoRNA polyadenylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    TRAMP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    non-canonical poly(A) RNA polymerase PAPD7
    Names
    DNA polymerase sigma
    PAP associated domain containing 7
    PAP-associated domain-containing protein 7
    TRAMP-like complex polyadenylate polymerase
    polymerase (DNA directed) sigma
    NP_001162602.1
    NP_941002.2
    XP_006517248.1
    XP_006517249.1
    XP_006517250.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001169131.1NP_001162602.1  non-canonical poly(A) RNA polymerase PAPD7 isoform 2

      See identical proteins and their annotated locations for NP_001162602.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC122484
      UniProtKB/TrEMBL
      Q3U7R5
      Conserved Domains (2) summary
      cd05402
      Location:10121
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      pfam03828
      Location:178238
      PAP_assoc; Cid1 family poly A polymerase
    2. NM_198600.2NP_941002.2  non-canonical poly(A) RNA polymerase PAPD7 isoform 1

      See identical proteins and their annotated locations for NP_941002.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC059846, BQ180094, CN525126
      Consensus CDS
      CCDS26622.1
      UniProtKB/Swiss-Prot
      Q6PB75
      Related
      ENSMUSP00000040757.7, ENSMUST00000044081.8
      Conserved Domains (2) summary
      cd05402
      Location:10121
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      pfam03828
      Location:178238
      PAP_assoc; Cid1 family poly A polymerase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      69497952..69534236 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517187.1XP_006517250.1  non-canonical poly(A) RNA polymerase PAPD7 isoform X3

      Conserved Domains (2) summary
      cd05402
      Location:253364
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      pfam03828
      Location:421481
      PAP_assoc; Cid1 family poly A polymerase
    2. XM_006517186.1XP_006517249.1  non-canonical poly(A) RNA polymerase PAPD7 isoform X2

      Conserved Domains (2) summary
      cd05402
      Location:253364
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      pfam03828
      Location:421481
      PAP_assoc; Cid1 family poly A polymerase
    3. XM_006517185.1XP_006517248.1  non-canonical poly(A) RNA polymerase PAPD7 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JDV2
      Related
      ENSMUSP00000142516.1, OTTMUSP00000043254, ENSMUST00000198607.4, OTTMUST00000081019
      Conserved Domains (2) summary
      cd05402
      Location:253364
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      pfam03828
      Location:421481
      PAP_assoc; Cid1 family poly A polymerase
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