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    Tent4a terminal nucleotidyltransferase 4A [ Mus musculus (house mouse) ]

    Gene ID: 210106, updated on 30-Aug-2022

    Summary

    Official Symbol
    Tent4aprovided by MGI
    Official Full Name
    terminal nucleotidyltransferase 4Aprovided by MGI
    Primary source
    MGI:MGI:2682295
    See related
    Ensembl:ENSMUSG00000034575 AllianceGenome:MGI:2682295
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    POLK; Pols; TRF4; LAK-1; Papd7; TRF4-1
    Summary
    Predicted to enable guanylyltransferase activity and polynucleotide adenylyltransferase activity. Predicted to be involved in RNA 3' uridylation; regulation of mRNA stability; and response to xenobiotic stimulus. Predicted to act upstream of or within mRNA processing. Predicted to be located in Golgi apparatus; nuclear membrane; and nucleoplasm. Predicted to be part of TRAMP complex. Predicted to be active in nucleolus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and musculoskeletal system. Orthologous to human TENT4A (terminal nucleotidyltransferase 4A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 10.5), adrenal adult (RPKM 9.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Tent4a in Genome Data Viewer
    Location:
    13 B3; 13 35.55 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (69646071..69682710, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (69497952..69534236, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (69636837..69672742, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35444 Neighboring gene predicted gene, 35514 Neighboring gene RIKEN cDNA A930018O16 gene Neighboring gene RIKEN cDNA A530095I07 gene Neighboring gene RAB geranylgeranyl transferase, b subunit pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC69673

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables guanylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables polynucleotide adenylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in RNA 3' uridylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in RNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in RNA polyadenylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of nuclear-transcribed mRNA poly(A) tail shortening ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of 3'-UTR-mediated mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of TRAMP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    terminal nucleotidyltransferase 4A
    Names
    DNA polymerase sigma
    PAP associated domain containing 7
    PAP-associated domain-containing protein 7
    TRAMP-like complex polyadenylate polymerase
    non-canonical poly(A) RNA polymerase PAPD7
    polymerase (DNA directed) sigma
    terminal guanylyltransferase
    XP_006517250.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001169131.2NP_001162602.2  terminal nucleotidyltransferase 4A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC122484
    2. NM_198600.3NP_941002.3  terminal nucleotidyltransferase 4A isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC122484
      Consensus CDS
      CCDS26622.1
      UniProtKB/TrEMBL
      A0A0G2JDV2
      Related
      ENSMUSP00000040757.8, ENSMUST00000044081.9

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      69646071..69682710 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517187.2XP_006517250.1  terminal nucleotidyltransferase 4A isoform X1

      Related
      ENSMUSP00000142516.2, ENSMUST00000198607.5
      Conserved Domains (1) summary
      COG5260
      Location:233538
      TRF4; DNA polymerase sigma [Replication, recombination and repair]