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    Sycp3 synaptonemal complex protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 20962, updated on 2-Oct-2018

    Summary

    Official Symbol
    Sycp3provided by MGI
    Official Full Name
    synaptonemal complex protein 3provided by MGI
    Primary source
    MGI:MGI:109542
    See related
    Ensembl:ENSMUSG00000020059 Vega:OTTMUSG00000023468
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cor1; Scp3
    Expression
    Biased expression in testis adult (RPKM 5.3), kidney adult (RPKM 2.4) and 12 other tissues See more
    Orthologs

    Genomic context

    See Sycp3 in Genome Data Viewer
    Location:
    10; 10 C1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (88459587..88473236)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (87922332..87935981)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40734 Neighboring gene predicted gene, 40733 Neighboring gene N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits Neighboring gene choline phosphotransferase 1 Neighboring gene myosin binding protein C, slow-type Neighboring gene ribosomal protein L7A pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Homologous recombination, organism-specific biosystem (from KEGG)
      Homologous recombination, organism-specific biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
    • Homologous recombination, conserved biosystem (from KEGG)
      Homologous recombination, conserved biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
    • Meiosis, organism-specific biosystem (from REACTOME)
      Meiosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Meiotic Synapsis, organism-specific biosystem (from REACTOME)
      Meiotic Synapsis, organism-specific biosystemMeiotic synapsis is the stable physical pairing of homologous chromosomes that begins in leptonema of prophase I and lasts until anaphase of prophase I. First, short segments of axial elements form a...
    • Meiotic synapsis, organism-specific biosystem (from REACTOME)
      Meiotic synapsis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Mus musculus biological processes, organism-specific biosystem (from REACTOME)
      Mus musculus biological processes, organism-specific biosystemCertain mouse pathways have been fully manually curated in Reactome in order to support the manual inference of well-conserved but less well-studied human pathways. These pathways include Circadian...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    chiasma assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chiasma assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    female meiosis chromosome segregation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    female meiosis chromosome separation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    female meiosis sister chromatid cohesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lateral element assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    meiotic DNA repair synthesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    meiotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sperm chromatin condensation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    spermatid development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    spermatogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spermatogenesis, exchange of chromosomal proteins ISO
    Inferred from Sequence Orthology
    more info
     
    synapsis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synaptonemal complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptonemal complex assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    condensed chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    condensed nuclear chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lateral element IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lateral element ISO
    Inferred from Sequence Orthology
    more info
     
    male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    synaptonemal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    synaptonemal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptonemal complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transverse filament IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    synaptonemal complex protein 3
    Names
    SCP-3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011517.2NP_035647.2  synaptonemal complex protein 3

      See identical proteins and their annotated locations for NP_035647.2

      Status: VALIDATED

      Source sequence(s)
      BC138509, BY386732
      Consensus CDS
      CCDS24111.1
      UniProtKB/Swiss-Prot
      P70281
      UniProtKB/TrEMBL
      A2RSE7
      Related
      ENSMUSP00000020252.3, OTTMUSP00000027498, ENSMUST00000020252.9, OTTMUST00000057079
      Conserved Domains (1) summary
      pfam04803
      Location:103222
      Cor1; Cor1/Xlr/Xmr conserved region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      88459587..88473236
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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