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    Gtf2h3 general transcription factor IIH, polypeptide 3 [ Mus musculus (house mouse) ]

    Gene ID: 209357, updated on 12-Mar-2019

    Summary

    Official Symbol
    Gtf2h3provided by MGI
    Official Full Name
    general transcription factor IIH, polypeptide 3provided by MGI
    Primary source
    MGI:MGI:1277143
    See related
    Ensembl:ENSMUSG00000029387
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BTF2; 34kDa; TFIIH; BTF2 p34; C730029A10; D5Ertd679e; 5033417D07Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 13.8), limb E14.5 (RPKM 12.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Gtf2h3 in Genome Data Viewer
    Location:
    5 F; 5 63.67 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (124579148..124597680)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (125029157..125047689)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 55 Neighboring gene eukaryotic translation initiation factor 2B, subunit 1 (alpha) Neighboring gene tectonic family member 2 Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit A2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to DNA-dependent ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to DNA-dependent ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to RNA polymerase II CTD heptapeptide repeat kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to RNA polymerase II CTD heptapeptide repeat kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphorylation of RNA polymerase II C-terminal domain IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    core TFIIH complex portion of holo TFIIH complex ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor TFIIH core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription factor TFIIH holo complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription factor TFIIH holo complex ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional preinitiation complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    general transcription factor IIH subunit 3
    Names
    BTF2-p34
    TFIIH basal transcription factor complex p34 subunit
    basic transcription factor 2 34 kDa subunit
    general transcription factor IIH, polypeptide 3, 34kDa

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181410.3NP_852075.1  general transcription factor IIH subunit 3

      See identical proteins and their annotated locations for NP_852075.1

      Status: VALIDATED

      Source sequence(s)
      AK050227, AK133941, BB637936
      Consensus CDS
      CCDS19680.1
      UniProtKB/Swiss-Prot
      Q8VD76
      UniProtKB/TrEMBL
      Q3UZB8
      Related
      ENSMUSP00000031333.3, ENSMUST00000031333.3
      Conserved Domains (1) summary
      TIGR00627
      Location:7290
      tfb4; transcription factor tfb4

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      124579148..124597680
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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