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    Gtf2h3 general transcription factor IIH, polypeptide 3 [ Mus musculus (house mouse) ]

    Gene ID: 209357, updated on 23-Jun-2021

    Summary

    Official Symbol
    Gtf2h3provided by MGI
    Official Full Name
    general transcription factor IIH, polypeptide 3provided by MGI
    Primary source
    MGI:MGI:1277143
    See related
    Ensembl:ENSMUSG00000029387
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    34kD; BTF2; 34kDa; TFIIH; BTF2 p34; D5Ertd679; C730029A10; D5Ertd679e; 5033417D07Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 13.8), limb E14.5 (RPKM 12.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Gtf2h3 in Genome Data Viewer
    Location:
    5 F; 5 63.67 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124717211..124735743)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (124579148..124597680)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (125029157..125047689)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene DEAD box helicase 55 Neighboring gene eukaryotic translation initiation factor 2B, subunit 1 (alpha) Neighboring gene tectonic family member 2 Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit A2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phosphorylation of RNA polymerase II C-terminal domain IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of core TFIIH complex portion of holo TFIIH complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription factor TFIIH core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of transcription factor TFIIH holo complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of transcription factor TFIIH holo complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription preinitiation complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    general transcription factor IIH subunit 3
    Names
    BTF2-p34
    TFIIH basal transcription factor complex p34 subunit
    basic transcription factor 2 34 kDa subunit
    general transcription factor IIH, polypeptide 3, 34kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181410.3NP_852075.1  general transcription factor IIH subunit 3

      See identical proteins and their annotated locations for NP_852075.1

      Status: VALIDATED

      Source sequence(s)
      AK050227, AK133941, BB637936
      Consensus CDS
      CCDS19680.1
      UniProtKB/Swiss-Prot
      Q8VD76
      UniProtKB/TrEMBL
      Q3UZB8
      Related
      ENSMUSP00000031333.4, ENSMUST00000031333.4
      Conserved Domains (1) summary
      TIGR00627
      Location:7290
      tfb4; transcription factor tfb4

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      124717211..124735743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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