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    Med22 mediator complex subunit 22 [ Mus musculus (house mouse) ]

    Gene ID: 20933, updated on 23-Jun-2021

    Summary

    Official Symbol
    Med22provided by MGI
    Official Full Name
    mediator complex subunit 22provided by MGI
    Primary source
    MGI:MGI:98446
    See related
    Ensembl:ENSMUSG00000015776
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sur; Surf; Surf5; Surf-5; AW212655; AW558812
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 19.6), ovary adult (RPKM 17.4) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Med22 in Genome Data Viewer
    Location:
    2 A3; 2 19.09 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (26795279..26800654, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (26905267..26910642, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (26760787..26766162, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase, transferase B, alpha 1-3-galactosyltransferase) Neighboring gene surfeit gene 6 Neighboring gene predicted gene, 23969 Neighboring gene predicted gene, 22879 Neighboring gene ribosomal protein L7A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of mediator complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    mediator of RNA polymerase II transcription subunit 22
    Names
    surfeit gene 5
    surfeit locus protein 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033908.1NP_001029080.1  mediator of RNA polymerase II transcription subunit 22 isoform 2

      See identical proteins and their annotated locations for NP_001029080.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses alternate splice sites in the coding region, compared to variant 1. The resulting isoform (2) is longer and has a unique C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AL773563, BG805496
      Consensus CDS
      CCDS15813.1
      UniProtKB/Swiss-Prot
      Q62276
      Related
      ENSMUSP00000015920.6, ENSMUST00000015920.12
      Conserved Domains (1) summary
      pfam06179
      Location:20124
      Med22; Surfeit locus protein 5 subunit 22 of Mediator complex
    2. NM_001378786.1NP_001365715.1  mediator of RNA polymerase II transcription subunit 22 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL773563
      Conserved Domains (1) summary
      pfam06179
      Location:20160
      Med22; Surfeit locus protein 5 subunit 22 of Mediator complex
    3. NM_001378787.1NP_001365716.1  mediator of RNA polymerase II transcription subunit 22 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL773563
      Conserved Domains (1) summary
      pfam06179
      Location:164
      Med22; Surfeit locus protein 5 subunit 22 of Mediator complex
    4. NM_001378788.1NP_001365717.1  mediator of RNA polymerase II transcription subunit 22 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL773563
      Conserved Domains (1) summary
      pfam06179
      Location:2097
      Med22; Surfeit locus protein 5 subunit 22 of Mediator complex
    5. NM_011513.2NP_035643.1  mediator of RNA polymerase II transcription subunit 22 isoform 1

      See identical proteins and their annotated locations for NP_035643.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the shorter protein (isoform 1).
      Source sequence(s)
      AL773563
      Consensus CDS
      CCDS15814.1
      UniProtKB/Swiss-Prot
      Q62276
      Related
      ENSMUSP00000099963.4, ENSMUST00000102899.10
      Conserved Domains (1) summary
      pfam06179
      Location:20124
      Med22; Surfeit locus protein 5 subunit 22 of Mediator complex

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      26795279..26800654 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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