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    Med22 mediator complex subunit 22 [ Mus musculus (house mouse) ]

    Gene ID: 20933, updated on 2-Oct-2018

    Summary

    Official Symbol
    Med22provided by MGI
    Official Full Name
    mediator complex subunit 22provided by MGI
    Primary source
    MGI:MGI:98446
    See related
    Ensembl:ENSMUSG00000015776 Vega:OTTMUSG00000011738
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Surf5; Surf-5; AW212655; AW558812
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 19.6), ovary adult (RPKM 17.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Med22 in Genome Data Viewer
    Location:
    2 A3; 2 19.09 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (26905262..26910672, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (26760787..26766162, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase, transferase B, alpha 1-3-galactosyltransferase) Neighboring gene surfeit gene 6 Neighboring gene ribosomal protein L7A Neighboring gene surfeit gene 1 Neighboring gene surfeit gene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mediator complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    mediator of RNA polymerase II transcription subunit 22
    Names
    surfeit gene 5
    surfeit locus protein 5

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033908.1NP_001029080.1  mediator of RNA polymerase II transcription subunit 22 isoform 2

      See identical proteins and their annotated locations for NP_001029080.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses alternate splice sites in the coding region, compared to variant 1. The resulting isoform (2) is longer and has a unique C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AL773563, BG805496
      Consensus CDS
      CCDS15813.1
      UniProtKB/Swiss-Prot
      Q62276
      Related
      ENSMUSP00000015920.5, OTTMUSP00000012503, ENSMUST00000015920.11, OTTMUST00000027510
      Conserved Domains (1) summary
      pfam06179
      Location:20124
      Med22; Surfeit locus protein 5 subunit 22 of Mediator complex
    2. NM_011513.2NP_035643.1  mediator of RNA polymerase II transcription subunit 22 isoform 1

      See identical proteins and their annotated locations for NP_035643.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the shorter protein (isoform 1).
      Source sequence(s)
      AL773563
      Consensus CDS
      CCDS15814.1
      UniProtKB/Swiss-Prot
      Q62276
      Related
      ENSMUSP00000099963.3, OTTMUSP00000012502, ENSMUST00000102899.9, OTTMUST00000027509
      Conserved Domains (1) summary
      pfam06179
      Location:20124
      Med22; Surfeit locus protein 5 subunit 22 of Mediator complex

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      26905262..26910672 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497829.1XP_006497892.1  mediator of RNA polymerase II transcription subunit 22 isoform X1

      Conserved Domains (1) summary
      pfam06179
      Location:20160
      Med22; Surfeit locus protein 5 subunit 22 of Mediator complex
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