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    Gps1 G protein pathway suppressor 1 [ Mus musculus (house mouse) ]

    Gene ID: 209318, updated on 23-Jun-2021

    Summary

    Official Symbol
    Gps1provided by MGI
    Official Full Name
    G protein pathway suppressor 1provided by MGI
    Primary source
    MGI:MGI:2384801
    See related
    Ensembl:ENSMUSG00000025156
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CO; Cs; Csn1; Sgn1; Cops1; R75577
    Expression
    Ubiquitous expression in ovary adult (RPKM 101.5), testis adult (RPKM 81.3) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Gps1 in Genome Data Viewer
    Location:
    11; 11 E2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120675086..120679928)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120784260..120789102)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (120645586..120650416)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene NADPH-dependent carbonyl reductase pseudogene Neighboring gene RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene dihydrouridine synthase 1-like (S. cerevisiae) Neighboring gene fatty acid synthase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC7191, MGC118012

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein deneddylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of COP9 signalosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    COP9 signalosome complex subunit 1
    Names
    JAB1-containing signalosome subunit 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177874.2NP_001171345.1  COP9 signalosome complex subunit 1 isoform 2

      See identical proteins and their annotated locations for NP_001171345.1

      Status: VALIDATED

      Source sequence(s)
      AL663090
      Consensus CDS
      CCDS49011.1
      UniProtKB/TrEMBL
      Q3MIA8
      Related
      ENSMUSP00000112007.2, ENSMUST00000116305.8
      Conserved Domains (2) summary
      pfam01399
      Location:320424
      PCI; PCI domain
      pfam10602
      Location:123305
      RPN7; 26S proteasome subunit RPN7
    2. NM_001346709.2NP_001333638.1  COP9 signalosome complex subunit 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL663090
      Consensus CDS
      CCDS83950.1
      UniProtKB/TrEMBL
      B1ATU4
      Related
      ENSMUSP00000097711.4, ENSMUST00000100134.10
      Conserved Domains (2) summary
      pfam01399
      Location:320424
      PCI; PCI domain
      pfam10602
      Location:123305
      RPN7; 26S proteasome subunit RPN7
    3. NM_001363440.1NP_001350369.1  COP9 signalosome complex subunit 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL663090
      Consensus CDS
      CCDS88299.1
      Related
      ENSMUSP00000147152.2, ENSMUST00000208737.2
      Conserved Domains (2) summary
      pfam01399
      Location:319423
      PCI; PCI domain
      pfam10602
      Location:123304
      RPN7; 26S proteasome subunit RPN7
    4. NM_145370.3NP_663345.2  COP9 signalosome complex subunit 1 isoform 1

      See identical proteins and their annotated locations for NP_663345.2

      Status: VALIDATED

      Source sequence(s)
      AL663090
      Consensus CDS
      CCDS25758.2
      UniProtKB/TrEMBL
      G3UXW9
      Related
      ENSMUSP00000133855.2, ENSMUST00000172809.2
      Conserved Domains (2) summary
      pfam01399
      Location:359463
      PCI; PCI domain
      pfam10602
      Location:162344
      RPN7; 26S proteasome subunit RPN7

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      120675086..120679928
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314411.1XP_017169900.1  COP9 signalosome complex subunit 1 isoform X4

      Conserved Domains (2) summary
      pfam01399
      Location:319423
      PCI; PCI domain
      pfam10602
      Location:123304
      RPN7; 26S proteasome subunit RPN7
    2. XM_006532744.3XP_006532807.1  COP9 signalosome complex subunit 1 isoform X1

      Conserved Domains (2) summary
      pfam01399
      Location:359463
      PCI; PCI domain
      pfam10602
      Location:162344
      RPN7; 26S proteasome subunit RPN7
    3. XM_017314409.2XP_017169898.1  COP9 signalosome complex subunit 1 isoform X2

      Conserved Domains (2) summary
      pfam01399
      Location:358462
      PCI; PCI domain
      pfam10602
      Location:162343
      RPN7; 26S proteasome subunit RPN7
    4. XM_017314410.3XP_017169899.1  COP9 signalosome complex subunit 1 isoform X3

      Conserved Domains (2) summary
      pfam01399
      Location:358462
      PCI; PCI domain
      pfam10602
      Location:162343
      RPN7; 26S proteasome subunit RPN7
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