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    Surf1 surfeit gene 1 [ Mus musculus (house mouse) ]

    Gene ID: 20930, updated on 18-Nov-2018

    Summary

    Official Symbol
    Surf1provided by MGI
    Official Full Name
    surfeit gene 1provided by MGI
    Primary source
    MGI:MGI:98443
    See related
    Ensembl:ENSMUSG00000015790 Vega:OTTMUSG00000011739
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Surf-1; 0610010F23Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 27.0), cerebellum adult (RPKM 26.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Surf1 in Genome Data Viewer
    Location:
    2 A3; 2 19.1 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (26913378..26916530, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (26768898..26772050, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 22 Neighboring gene ribosomal protein L7A Neighboring gene surfeit gene 2 Neighboring gene surfeit gene 4 Neighboring gene predicted gene, 36591 Neighboring gene serine/threonine kinase-like domain containing 1 Neighboring gene predicted gene, 39775

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Electron Transport Chain, organism-specific biosystem (from WikiPathways)
      Electron Transport Chain, organism-specific biosystemAn electron transport chain(ETC) couples a chemical reaction between an electron donor (such as NADH) and an electron acceptor (such as O2) to the transfer of H+ ions across a membrane, through a set...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cytochrome-c oxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    mitochondrial respiratory chain complex IV assembly ISO
    Inferred from Sequence Orthology
    more info
     
    oxidative phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    surfeit locus protein 1
    NP_001258653.2
    NP_038705.2
    XP_006497884.1
    XP_006497886.1
    XP_006497887.1
    XP_006497888.1
    XP_006497889.1
    XP_011237350.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271724.1NP_001258653.2  surfeit locus protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. An in-frame AUG is located 32 codons upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is in a weak Kozak sequence context.
      Source sequence(s)
      AK002469, AL773563, BE955575
      UniProtKB/Swiss-Prot
      P09925
      Conserved Domains (1) summary
      pfam02104
      Location:74277
      SURF1; SURF1 family
    2. NM_013677.2NP_038705.2  surfeit locus protein 1 isoform 1

      See identical proteins and their annotated locations for NP_038705.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). An in-frame AUG is located 32 codons upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is in a weak Kozak sequence context.
      Source sequence(s)
      AK002469, AL773563, BE955575, BU697260, CB524655
      Consensus CDS
      CCDS50543.1
      UniProtKB/Swiss-Prot
      P09925
      Related
      ENSMUSP00000015934.7, OTTMUSP00000012505, ENSMUST00000015934.12, OTTMUST00000027512
      Conserved Domains (1) summary
      cd06662
      Location:81294
      SURF1; SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring ...

    RNA

    1. NR_073420.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' exon structure compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK002469, AL773563, BE955575, BY268659, CB524655
      Related
      ENSMUST00000167661.6, OTTMUST00000027513

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      26913378..26916530 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497826.3XP_006497889.1  surfeit locus protein 1 isoform X4

      Conserved Domains (1) summary
      pfam02104
      Location:106208
      SURF1; SURF1 family
    2. XM_006497823.3XP_006497886.1  surfeit locus protein 1 isoform X2

      Conserved Domains (1) summary
      cd06662
      Location:45258
      SURF1; SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring ...
    3. XM_006497821.3XP_006497884.1  surfeit locus protein 1 isoform X1

      Conserved Domains (1) summary
      cd06662
      Location:69282
      SURF1; SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring ...
    4. XM_006497824.3XP_006497887.1  surfeit locus protein 1 isoform X3

      See identical proteins and their annotated locations for XP_006497887.1

      UniProtKB/TrEMBL
      I6L9E0
      Related
      ENSMUSP00000141238.1, OTTMUSP00000068633, ENSMUST00000147110.7, OTTMUST00000027515
      Conserved Domains (1) summary
      cd06662
      Location:38251
      SURF1; SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring ...
    5. XM_006497825.3XP_006497888.1  surfeit locus protein 1 isoform X3

      See identical proteins and their annotated locations for XP_006497888.1

      UniProtKB/TrEMBL
      I6L9E0
      Conserved Domains (1) summary
      cd06662
      Location:38251
      SURF1; SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring ...
    6. XM_011239048.2XP_011237350.1  surfeit locus protein 1 isoform X3

      See identical proteins and their annotated locations for XP_011237350.1

      UniProtKB/TrEMBL
      I6L9E0
      Conserved Domains (1) summary
      cd06662
      Location:38251
      SURF1; SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring ...

    RNA

    1. XR_374066.3 RNA Sequence

      Related
      ENSMUST00000183520.7, OTTMUST00000027518
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