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    Supt5 suppressor of Ty 5, DSIF elongation factor subunit [ Mus musculus (house mouse) ]

    Gene ID: 20924, updated on 23-Jun-2021

    Summary

    Official Symbol
    Supt5provided by MGI
    Official Full Name
    suppressor of Ty 5, DSIF elongation factor subunitprovided by MGI
    Primary source
    MGI:MGI:1202400
    See related
    Ensembl:ENSMUSG00000003435
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sp; Spt5; Supt; Supt5h; AL033283; AL033321; AU019549
    Expression
    Ubiquitous expression in thymus adult (RPKM 68.8), adrenal adult (RPKM 67.5) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Supt5 in Genome Data Viewer
    Location:
    7 A3; 7 16.68 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28014316..28038341, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28314891..28338804, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (29099913..29123738, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene delta like canonical Notch ligand 3 Neighboring gene translocase of inner mitochondrial membrane 50 Neighboring gene predicted gene, 51445 Neighboring gene snoRNA AF357399 Neighboring gene ribosomal protein S16 Neighboring gene pleckstrin homology domain containing, family G (with RhoGef domain) member 2 Neighboring gene nuclear encoded tRNA isoleucine 16 (anticodon TAT)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of DSIF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of DSIF complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transcription elongation factor SPT5
    Names
    DRB sensitivity-inducing factor large subunit
    DSIF large subunit
    suppressor of Ty 5 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013676.1NP_038704.1  transcription elongation factor SPT5

      See identical proteins and their annotated locations for NP_038704.1

      Status: PROVISIONAL

      Source sequence(s)
      BC007132
      Consensus CDS
      CCDS39857.1
      UniProtKB/Swiss-Prot
      O55201
      Related
      ENSMUSP00000003527.9, ENSMUST00000003527.10
      Conserved Domains (12) summary
      PRK08559
      Location:173314
      nusG; transcription antitermination protein NusG; Validated
      cd09888
      Location:176263
      NGN_Euk; Eukaryotic N-Utilization Substance G (NusG) N-terminal (NGN) domain, including plant KTF1 (KOW domain-containing Transcription Factor 1)
      COG5164
      Location:332959
      SPT5; Transcription elongation factor [Transcription]
      cd06081
      Location:274311
      KOW_Spt5_1; KOW domain of Spt5, repeat 1
      cd06082
      Location:418468
      KOW_Spt5_2; KOW domain of Spt5, repeat 2
      cd06083
      Location:469519
      KOW_Spt5_3; KOW domain of Spt5, repeat 3
      cd06084
      Location:595637
      KOW_Spt5_4; KOW domain of Spt5, repeat 4
      cd06085
      Location:696745
      KOW_Spt5_5; KOW domain of Spt5, repeat 5
      cd06086
      Location:10221079
      KOW_Spt5_6; KOW domain of Spt5, repeat 6
      pfam04731
      Location:841970
      Caudal_act; Caudal like protein activation region
      pfam11942
      Location:91169
      Spt5_N; Spt5 transcription elongation factor, acidic N-terminal
      pfam12815
      Location:760816
      CTD; Spt5 C-terminal nonapeptide repeat binding Spt4

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      28014316..28038341 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539702.3XP_006539765.1  transcription elongation factor SPT5 isoform X1

      Conserved Domains (5) summary
      cd09888
      Location:172259
      NGN_Euk; Eukaryotic N-Utilization Substance G (NusG) N-terminal (NGN) domain, including plant KTF1 (KOW domain-containing Transcription Factor 1)
      COG5164
      Location:328955
      SPT5; Transcription elongation factor [Transcription]
      cd06081
      Location:270307
      KOW_Spt5_1; KOW domain of Spt5, repeat 1
      cd06086
      Location:10181075
      KOW_Spt5_6; KOW domain of Spt5, repeat 6
      pfam11942
      Location:73165
      Spt5_N; Spt5 transcription elongation factor, acidic N-terminal
    2. XM_006539703.3XP_006539766.1  transcription elongation factor SPT5 isoform X2

      Conserved Domains (5) summary
      cd09888
      Location:176263
      NGN_Euk; Eukaryotic N-Utilization Substance G (NusG) N-terminal (NGN) domain, including plant KTF1 (KOW domain-containing Transcription Factor 1)
      COG5164
      Location:332906
      SPT5; Transcription elongation factor [Transcription]
      cd06081
      Location:274311
      KOW_Spt5_1; KOW domain of Spt5, repeat 1
      cd06086
      Location:9691026
      KOW_Spt5_6; KOW domain of Spt5, repeat 6
      pfam11942
      Location:73169
      Spt5_N; Spt5 transcription elongation factor, acidic N-terminal
    3. XM_036152859.1XP_036008752.1  transcription elongation factor SPT5 isoform X3

      Conserved Domains (4) summary
      cd09888
      Location:37124
      NGN_Euk; Eukaryotic N-Utilization Substance G (NusG) N-terminal (NGN) domain, including plant KTF1 (KOW domain-containing Transcription Factor 1)
      COG5164
      Location:193820
      SPT5; Transcription elongation factor [Transcription]
      cd06081
      Location:135172
      KOW_Spt5_1; KOW domain of Spt5, repeat 1
      cd06086
      Location:883940
      KOW_Spt5_6; KOW domain of Spt5, repeat 6
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