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    Supt5 suppressor of Ty 5 [ Mus musculus (house mouse) ]

    Gene ID: 20924, updated on 2-Oct-2018

    Summary

    Official Symbol
    Supt5provided by MGI
    Official Full Name
    suppressor of Ty 5provided by MGI
    Primary source
    MGI:MGI:1202400
    See related
    Ensembl:ENSMUSG00000003435 Vega:OTTMUSG00000059053
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Spt5; Supt5h; AL033283; AL033321; AU019549
    Expression
    Ubiquitous expression in thymus adult (RPKM 68.8), adrenal adult (RPKM 67.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Supt5 in Genome Data Viewer
    Location:
    7 A3; 7 16.68 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (28314891..28338804, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (29099913..29123738, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene delta like canonical Notch ligand 3 Neighboring gene translocase of inner mitochondrial membrane 50 Neighboring gene snoRNA AF357399 Neighboring gene ribosomal protein S16 Neighboring gene pleckstrin homology domain containing, family G (with RhoGef domain) member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    DSIF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DSIF complex ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transcription elongation factor SPT5
    Names
    DRB sensitivity-inducing factor large subunit
    DSIF large subunit
    suppressor of Ty 5 homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013676.1NP_038704.1  transcription elongation factor SPT5

      See identical proteins and their annotated locations for NP_038704.1

      Status: PROVISIONAL

      Source sequence(s)
      BC007132
      Consensus CDS
      CCDS39857.1
      UniProtKB/Swiss-Prot
      O55201
      Related
      ENSMUSP00000003527.8, OTTMUSP00000075480, ENSMUST00000003527.9, OTTMUST00000144874
      Conserved Domains (12) summary
      PRK08559
      Location:173314
      nusG; transcription antitermination protein NusG; Validated
      cd09888
      Location:176263
      NGN_Euk; Eukaryotic N-Utilization Substance G (NusG) N-terminal (NGN) domain, including plant KTF1 (KOW domain-containing Transcription Factor 1)
      COG5164
      Location:332959
      SPT5; Transcription elongation factor [Transcription]
      cd06081
      Location:274311
      KOW_Spt5_1; KOW domain of Spt5, repeat 1
      cd06082
      Location:418468
      KOW_Spt5_2; KOW domain of Spt5, repeat 2
      cd06083
      Location:469519
      KOW_Spt5_3; KOW domain of Spt5, repeat 3
      cd06084
      Location:595637
      KOW_Spt5_4; KOW domain of Spt5, repeat 4
      cd06085
      Location:696745
      KOW_Spt5_5; KOW domain of Spt5, repeat 5
      cd06086
      Location:10221079
      KOW_Spt5_6; KOW domain of Spt5, repeat 6
      pfam04731
      Location:841970
      Caudal_act; Caudal like protein activation region
      pfam11942
      Location:91169
      Spt5_N; Spt5 transcription elongation factor, acidic N-terminal
      pfam12815
      Location:760816
      CTD; Spt5 C-terminal nonapeptide repeat binding Spt4

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      28314891..28338804 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539702.2XP_006539765.1  transcription elongation factor SPT5 isoform X1

      Conserved Domains (12) summary
      PRK08559
      Location:169310
      nusG; transcription antitermination protein NusG; Validated
      cd09888
      Location:172259
      NGN_Euk; Eukaryotic N-Utilization Substance G (NusG) N-terminal (NGN) domain, including plant KTF1 (KOW domain-containing Transcription Factor 1)
      COG5164
      Location:328955
      SPT5; Transcription elongation factor [Transcription]
      cd06081
      Location:270307
      KOW_Spt5_1; KOW domain of Spt5, repeat 1
      cd06082
      Location:414464
      KOW_Spt5_2; KOW domain of Spt5, repeat 2
      cd06083
      Location:465515
      KOW_Spt5_3; KOW domain of Spt5, repeat 3
      cd06084
      Location:591633
      KOW_Spt5_4; KOW domain of Spt5, repeat 4
      cd06085
      Location:692741
      KOW_Spt5_5; KOW domain of Spt5, repeat 5
      cd06086
      Location:10181075
      KOW_Spt5_6; KOW domain of Spt5, repeat 6
      pfam04731
      Location:837966
      Caudal_act; Caudal like protein activation region
      pfam11942
      Location:73165
      Spt5_N; Spt5 transcription elongation factor, acidic N-terminal
      pfam12815
      Location:756812
      CTD; Spt5 C-terminal nonapeptide repeat binding Spt4
    2. XM_006539703.2XP_006539766.1  transcription elongation factor SPT5 isoform X2

      Conserved Domains (12) summary
      PRK08559
      Location:173314
      nusG; transcription antitermination protein NusG; Validated
      cd09888
      Location:176263
      NGN_Euk; Eukaryotic N-Utilization Substance G (NusG) N-terminal (NGN) domain, including plant KTF1 (KOW domain-containing Transcription Factor 1)
      COG5164
      Location:332906
      SPT5; Transcription elongation factor [Transcription]
      cd06081
      Location:274311
      KOW_Spt5_1; KOW domain of Spt5, repeat 1
      cd06082
      Location:418468
      KOW_Spt5_2; KOW domain of Spt5, repeat 2
      cd06083
      Location:469519
      KOW_Spt5_3; KOW domain of Spt5, repeat 3
      cd06084
      Location:595637
      KOW_Spt5_4; KOW domain of Spt5, repeat 4
      cd06085
      Location:696745
      KOW_Spt5_5; KOW domain of Spt5, repeat 5
      cd06086
      Location:9691026
      KOW_Spt5_6; KOW domain of Spt5, repeat 6
      pfam04731
      Location:771917
      Caudal_act; Caudal like protein activation region
      pfam11942
      Location:91169
      Spt5_N; Spt5 transcription elongation factor, acidic N-terminal
      pfam12815
      Location:760816
      CTD; Spt5 C-terminal nonapeptide repeat binding Spt4
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