Format

Send to:

Choose Destination
    • Showing Current items.

    Suclg2 succinate-Coenzyme A ligase, GDP-forming, beta subunit [ Mus musculus (house mouse) ]

    Gene ID: 20917, updated on 23-Jun-2021

    Summary

    Official Symbol
    Suclg2provided by MGI
    Official Full Name
    succinate-Coenzyme A ligase, GDP-forming, beta subunitprovided by MGI
    Primary source
    MGI:MGI:1306824
    See related
    Ensembl:ENSMUSG00000061838
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G-SCS; GTPSCS; AF171077; AW556404; D6Wsu120; D6Wsu120e; SCS-betaG
    Expression
    Ubiquitous expression in kidney adult (RPKM 29.5), liver adult (RPKM 17.1) and 27 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Suclg2 in Genome Data Viewer
    Location:
    6 D2; 6 44.63 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (95449990..95695850, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (95473009..95718858, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (95424128..95668831, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene cDNA sequence AY512915 Neighboring gene predicted gene, 53325 Neighboring gene predicted gene, 32009 Neighboring gene predicted gene, 38864

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC91183

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables succinate-CoA ligase (GDP-forming) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables succinate-semialdehyde dehydrogenase (NAD+) activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in succinyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of succinate-CoA ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
    Names
    GTP-specific succinyl-CoA synthetase beta subunit
    succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
    succinyl-CoA synthetase beta-G chain
    NP_001313487.1
    NP_035637.2
    XP_030111155.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001326558.1NP_001313487.1  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AI482427, AK045176, AK167136, AK167339
      Consensus CDS
      CCDS85100.1
      UniProtKB/Swiss-Prot
      Q9Z2I8
      Related
      ENSMUSP00000078774.7, ENSMUST00000079847.8
      Conserved Domains (3) summary
      PRK00696
      Location:2372
      sucC; succinyl-CoA synthetase subunit beta; Provisional
      pfam00549
      Location:258372
      Ligase_CoA; CoA-ligase
      pfam08442
      Location:1199
      ATP-grasp_2; ATP-grasp domain
    2. NM_011507.3NP_035637.2  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_035637.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC121612, AI482427, AK045176, AK167136
      Consensus CDS
      CCDS20381.1
      UniProtKB/Swiss-Prot
      Q9Z2I8
      Related
      ENSMUSP00000144827.2, ENSMUST00000204224.3
      Conserved Domains (3) summary
      PRK00696
      Location:40421
      sucC; succinyl-CoA synthetase subunit beta; Provisional
      pfam00549
      Location:307421
      Ligase_CoA; CoA-ligase
      pfam08442
      Location:40248
      ATP-grasp_2; ATP-grasp domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      95449990..95695850 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255295.1XP_030111155.1  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform X1

      Conserved Domains (1) summary
      cl29683
      Location:1301
      sucC; ADP-forming succinate--CoA ligase subunit beta

    RNA

    1. XR_003956174.2 RNA Sequence

    Support Center