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    Suclg2 succinate-Coenzyme A ligase, GDP-forming, beta subunit [ Mus musculus (house mouse) ]

    Gene ID: 20917, updated on 31-Jan-2019

    Summary

    Official Symbol
    Suclg2provided by MGI
    Official Full Name
    succinate-Coenzyme A ligase, GDP-forming, beta subunitprovided by MGI
    Primary source
    MGI:MGI:1306824
    See related
    Ensembl:ENSMUSG00000061838
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G-SCS; GTPSCS; AF171077; AW556404; D6Wsu120e; SCS-betaG
    Expression
    Ubiquitous expression in kidney adult (RPKM 29.5), liver adult (RPKM 17.1) and 27 other tissues See more
    Orthologs

    Genomic context

    See Suclg2 in Genome Data Viewer
    Location:
    6 D2; 6 44.63 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (95473009..95718858, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (95424128..95668831, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene Neighboring gene cDNA sequence AY512915 Neighboring gene predicted gene, 32009 Neighboring gene predicted gene, 38864

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC91183

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GDP binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    succinate-CoA ligase (GDP-forming) activity ISO
    Inferred from Sequence Orthology
    more info
     
    succinate-semialdehyde dehydrogenase (NAD+) activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    Process Evidence Code Pubs
    succinate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    succinyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    tricarboxylic acid cycle ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    mitochondrion HDA PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    succinate-CoA ligase complex (GDP-forming) ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
    Names
    GTP-specific succinyl-CoA synthetase beta subunit
    succinyl-CoA synthetase beta-G chain
    NP_001313487.1
    NP_035637.2
    XP_017176970.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001326558.1NP_001313487.1  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AI482427, AK045176, AK167136, AK167339
      Consensus CDS
      CCDS85100.1
      UniProtKB/Swiss-Prot
      Q9Z2I8
      Related
      ENSMUSP00000078774.6, ENSMUST00000079847.7
      Conserved Domains (3) summary
      PRK00696
      Location:2372
      sucC; succinyl-CoA synthetase subunit beta; Provisional
      pfam00549
      Location:258372
      Ligase_CoA; CoA-ligase
      pfam08442
      Location:1199
      ATP-grasp_2; ATP-grasp domain
    2. NM_011507.3NP_035637.2  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_035637.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC121612, AI482427, AK045176, AK167136
      Consensus CDS
      CCDS20381.1
      UniProtKB/Swiss-Prot
      Q9Z2I8
      Related
      ENSMUSP00000144827.1, ENSMUST00000204224.2
      Conserved Domains (3) summary
      PRK00696
      Location:40421
      sucC; succinyl-CoA synthetase subunit beta; Provisional
      pfam00549
      Location:307421
      Ligase_CoA; CoA-ligase
      pfam08442
      Location:40248
      ATP-grasp_2; ATP-grasp domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      95473009..95718858 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321481.1XP_017176970.1  succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial isoform X1

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