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    Ulk4 unc-51-like kinase 4 [ Mus musculus (house mouse) ]

    Gene ID: 209012, updated on 5-Sep-2021

    Summary

    Official Symbol
    Ulk4provided by MGI
    Official Full Name
    unc-51-like kinase 4provided by MGI
    Primary source
    MGI:MGI:1921622
    See related
    Ensembl:ENSMUSG00000040936
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A730098P15; 4932415A06Rik
    Expression
    Biased expression in testis adult (RPKM 56.7) and ovary adult (RPKM 3.4) See more
    Orthologs
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    Genomic context

    See Ulk4 in Genome Data Viewer
    Location:
    9; 9 F4
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (120793520..121115225, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (120964454..121286159, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (120873572..121186290, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930593C16 gene Neighboring gene predicted gene, 38502 Neighboring gene catenin (cadherin associated protein), beta 1 Neighboring gene microRNA 7090 Neighboring gene predicted gene, 34945 Neighboring gene zinc finger protein 606 pseudogene Neighboring gene predicted gene, 34735 Neighboring gene VISTA enhancer mm1661 Neighboring gene predicted gene, 34655 Neighboring gene trafficking protein, kinesin binding 1 Neighboring gene predicted gene, 51661

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within GABAergic neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within adult behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within central nervous system myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cerebrospinal fluid circulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ciliary basal body organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within corpus callosum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuroinflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuronal stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of protein kinase C signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within social behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ventricular system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase ULK4
    NP_808257.2
    XP_006512086.1
    XP_006512087.1
    XP_006512088.1
    XP_006512089.1
    XP_011241254.1
    XP_017168752.1
    XP_030100042.1
    XP_030100043.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177589.3NP_808257.2  serine/threonine-protein kinase ULK4

      Status: VALIDATED

      Source sequence(s)
      AK132731, AW456669, BC065094, BM938704
      Consensus CDS
      CCDS52967.1
      UniProtKB/Swiss-Prot
      Q3V129
      UniProtKB/TrEMBL
      E9Q2P5
      Related
      ENSMUSP00000131342.2, ENSMUST00000171923.8
      Conserved Domains (1) summary
      cd14010
      Location:3280
      STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      120793520..121115225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512024.4XP_006512087.1  serine/threonine-protein kinase ULK4 isoform X1

      See identical proteins and their annotated locations for XP_006512087.1

      Conserved Domains (1) summary
      cd14010
      Location:3280
      STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
    2. XM_030244183.2XP_030100043.1  serine/threonine-protein kinase ULK4 isoform X2

      Conserved Domains (1) summary
      cd14010
      Location:3280
      STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
    3. XM_030244182.1XP_030100042.1  serine/threonine-protein kinase ULK4 isoform X2

      Conserved Domains (1) summary
      cd14010
      Location:3280
      STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
    4. XM_006512023.3XP_006512086.1  serine/threonine-protein kinase ULK4 isoform X1

      See identical proteins and their annotated locations for XP_006512086.1

      Conserved Domains (1) summary
      cd14010
      Location:3280
      STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
    5. XM_017313263.3XP_017168752.1  serine/threonine-protein kinase ULK4 isoform X1

      Conserved Domains (1) summary
      cd14010
      Location:3280
      STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
    6. XM_006512025.5XP_006512088.1  serine/threonine-protein kinase ULK4 isoform X3

      Conserved Domains (1) summary
      cd14010
      Location:3280
      STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
    7. XM_006512026.4XP_006512089.1  serine/threonine-protein kinase ULK4 isoform X5

    8. XM_011242952.4XP_011241254.1  serine/threonine-protein kinase ULK4 isoform X4

      Related
      ENSMUSP00000129214.2, ENSMUST00000171061.8
      Conserved Domains (1) summary
      cd14010
      Location:3280
      STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
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