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    Ulk4 unc-51-like kinase 4 [ Mus musculus (house mouse) ]

    Gene ID: 209012, updated on 7-Jul-2018

    Summary

    Official Symbol
    Ulk4provided by MGI
    Official Full Name
    unc-51-like kinase 4provided by MGI
    Primary source
    MGI:MGI:1921622
    See related
    Ensembl:ENSMUSG00000040936 Vega:OTTMUSG00000036158
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A730098P15; 4932415A06Rik
    Expression
    Biased expression in testis adult (RPKM 56.7) and ovary adult (RPKM 3.4) See more
    Orthologs

    Genomic context

    See Ulk4 in Genome Data Viewer
    Location:
    9; 9 F4
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (120964454..121286187, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (120873572..121186290, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930593C16 gene Neighboring gene predicted gene, 38502 Neighboring gene catenin (cadherin associated protein), beta 1 Neighboring gene microRNA 7090 Neighboring gene predicted gene, 34945 Neighboring gene zinc finger protein 606 pseudogene Neighboring gene predicted gene, 34735 Neighboring gene predicted gene, 34655 Neighboring gene trafficking protein, kinesin binding 1 Neighboring gene cholecystokinin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Related articles in PubMed

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    corpus callosum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial cilium movement IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein kinase C signaling ISO
    Inferred from Sequence Orthology
    more info
     
    ventricular system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase ULK4
    NP_808257.2
    XP_006512085.1
    XP_006512086.1
    XP_006512087.1
    XP_006512088.1
    XP_006512089.1
    XP_011241254.1
    XP_017168752.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177589.3NP_808257.2  serine/threonine-protein kinase ULK4

      Status: VALIDATED

      Source sequence(s)
      AK132731, AW456669, BC065094, BM938704
      Consensus CDS
      CCDS52967.1
      UniProtKB/Swiss-Prot
      Q3V129
      UniProtKB/TrEMBL
      E9Q2P5
      Related
      ENSMUSP00000131342.1, OTTMUSP00000051478, ENSMUST00000171923.7, OTTMUST00000092956
      Conserved Domains (3) summary
      smart00220
      Location:4279
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00020
      Location:646756
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      cd14010
      Location:3280
      STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      120964454..121286187 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512024.3XP_006512087.1  serine/threonine-protein kinase ULK4 isoform X1

      See identical proteins and their annotated locations for XP_006512087.1

      Conserved Domains (3) summary
      smart00220
      Location:4279
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00020
      Location:647757
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      cd14010
      Location:3280
      STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
    2. XM_006512022.3XP_006512085.1  serine/threonine-protein kinase ULK4 isoform X1

      See identical proteins and their annotated locations for XP_006512085.1

      Conserved Domains (3) summary
      smart00220
      Location:4279
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00020
      Location:647757
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      cd14010
      Location:3280
      STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
    3. XM_006512023.3XP_006512086.1  serine/threonine-protein kinase ULK4 isoform X1

      See identical proteins and their annotated locations for XP_006512086.1

      Conserved Domains (3) summary
      smart00220
      Location:4279
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00020
      Location:647757
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      cd14010
      Location:3280
      STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
    4. XM_006512025.3XP_006512088.1  serine/threonine-protein kinase ULK4 isoform X2

      Conserved Domains (3) summary
      smart00220
      Location:4279
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00020
      Location:619729
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      cd14010
      Location:3280
      STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
    5. XM_017313263.1XP_017168752.1  serine/threonine-protein kinase ULK4 isoform X1

      Conserved Domains (3) summary
      smart00220
      Location:4279
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00020
      Location:647757
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      cd14010
      Location:3280
      STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
    6. XM_006512026.3XP_006512089.1  serine/threonine-protein kinase ULK4 isoform X4

      Conserved Domains (1) summary
      cd00020
      Location:111221
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    7. XM_011242952.2XP_011241254.1  serine/threonine-protein kinase ULK4 isoform X3

      Related
      ENSMUSP00000129214.1, OTTMUSP00000051475, ENSMUST00000171061.7, OTTMUST00000092948
      Conserved Domains (3) summary
      smart00220
      Location:4279
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00020
      Location:647757
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      cd14010
      Location:3280
      STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
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