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    Daam1 dishevelled associated activator of morphogenesis 1 [ Mus musculus (house mouse) ]

    Gene ID: 208846, updated on 23-Jun-2021

    Summary

    Official Symbol
    Daam1provided by MGI
    Official Full Name
    dishevelled associated activator of morphogenesis 1provided by MGI
    Primary source
    MGI:MGI:1914596
    See related
    Ensembl:ENSMUSG00000034574
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Ubiquitous expression in CNS E18 (RPKM 12.5), whole brain E14.5 (RPKM 8.6) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Daam1 in Genome Data Viewer
    Location:
    12; 12 C3
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (71877724..72039150)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (71830950..71992376)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (72932065..73093354)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9630002D21 gene Neighboring gene predicted gene, 46356 Neighboring gene UPF0538 protein C2orf76 homolog pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 53214 Neighboring gene predicted gene, 40440

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • mKIAA0666, E130308H01, 1700066F09Rik, 2310028E21Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular component organization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    disheveled-associated activator of morphogenesis 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286452.1NP_001273381.1  disheveled-associated activator of morphogenesis 1 isoform b

      See identical proteins and their annotated locations for NP_001273381.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a.
      Source sequence(s)
      AC159186, AK033683, AK147480, AK162231, BC076585
      Consensus CDS
      CCDS88349.1
      UniProtKB/Swiss-Prot
      Q8BPM0
      UniProtKB/TrEMBL
      Q8BTF1
      Related
      ENSMUSP00000152532.2, ENSMUST00000221317.2
      Conserved Domains (4) summary
      PRK12704
      Location:444513
      PRK12704; phosphodiesterase; Provisional
      pfam02181
      Location:600973
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:235439
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:45232
      Drf_GBD; Diaphanous GTPase-binding Domain
    2. NM_026102.3NP_080378.2  disheveled-associated activator of morphogenesis 1 isoform a

      See identical proteins and their annotated locations for NP_080378.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AC124356, AK033683, AK162231, BC076585, CD352113
      Consensus CDS
      CCDS25964.1
      UniProtKB/Swiss-Prot
      Q8BPM0
      UniProtKB/TrEMBL
      Q8BTF1
      Related
      ENSMUSP00000082406.3, ENSMUST00000085299.4
      Conserved Domains (4) summary
      PRK12704
      Location:444513
      PRK12704; phosphodiesterase; Provisional
      pfam06367
      Location:235439
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:600982
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:45232
      Drf_GBD; Diaphanous GTPase-binding Domain
    3. NM_172464.3NP_766052.2  disheveled-associated activator of morphogenesis 1 isoform a

      See identical proteins and their annotated locations for NP_766052.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AC124356, AK033683, AK162231, BC076585
      Consensus CDS
      CCDS25964.1
      UniProtKB/Swiss-Prot
      Q8BPM0
      UniProtKB/TrEMBL
      Q8BTF1
      Related
      ENSMUSP00000152564.2, ENSMUST00000223272.2
      Conserved Domains (4) summary
      PRK12704
      Location:444513
      PRK12704; phosphodiesterase; Provisional
      pfam06367
      Location:235439
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:600982
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:45232
      Drf_GBD; Diaphanous GTPase-binding Domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      71877724..72039150
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515643.4XP_006515706.1  disheveled-associated activator of morphogenesis 1 isoform X2

      See identical proteins and their annotated locations for XP_006515706.1

      UniProtKB/Swiss-Prot
      Q8BPM0
      Conserved Domains (4) summary
      PRK12704
      Location:444513
      PRK12704; phosphodiesterase; Provisional
      pfam02181
      Location:600973
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:235439
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:45232
      Drf_GBD; Diaphanous GTPase-binding Domain
    2. XM_030246636.1XP_030102496.1  disheveled-associated activator of morphogenesis 1 isoform X1

      Conserved Domains (4) summary
      PRK12704
      Location:444513
      PRK12704; phosphodiesterase; Provisional
      pfam06367
      Location:235439
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:600982
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:45232
      Drf_GBD; Diaphanous GTPase-binding Domain
    3. XM_006515644.4XP_006515707.1  disheveled-associated activator of morphogenesis 1 isoform X2

      See identical proteins and their annotated locations for XP_006515707.1

      UniProtKB/Swiss-Prot
      Q8BPM0
      Conserved Domains (4) summary
      PRK12704
      Location:444513
      PRK12704; phosphodiesterase; Provisional
      pfam02181
      Location:600973
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:235439
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:45232
      Drf_GBD; Diaphanous GTPase-binding Domain
    4. XM_036157296.1XP_036013189.1  disheveled-associated activator of morphogenesis 1 isoform X1

      Conserved Domains (4) summary
      PRK12704
      Location:444513
      PRK12704; phosphodiesterase; Provisional
      pfam06367
      Location:235439
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:600982
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:45232
      Drf_GBD; Diaphanous GTPase-binding Domain
    5. XM_036157297.1XP_036013190.1  disheveled-associated activator of morphogenesis 1 isoform X1

      Conserved Domains (4) summary
      PRK12704
      Location:444513
      PRK12704; phosphodiesterase; Provisional
      pfam06367
      Location:235439
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:600982
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:45232
      Drf_GBD; Diaphanous GTPase-binding Domain
    6. XM_006515642.4XP_006515705.1  disheveled-associated activator of morphogenesis 1 isoform X1

      See identical proteins and their annotated locations for XP_006515705.1

      UniProtKB/Swiss-Prot
      Q8BPM0
      Conserved Domains (4) summary
      PRK12704
      Location:444513
      PRK12704; phosphodiesterase; Provisional
      pfam06367
      Location:235439
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:600982
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:45232
      Drf_GBD; Diaphanous GTPase-binding Domain
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