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    Slk STE20-like kinase [ Mus musculus (house mouse) ]

    Gene ID: 20874, updated on 5-Sep-2021

    Summary

    Official Symbol
    Slkprovided by MGI
    Official Full Name
    STE20-like kinaseprovided by MGI
    Primary source
    MGI:MGI:103241
    See related
    Ensembl:ENSMUSG00000025060
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S; 9A; mS; 9A2; Stk; Etk4; SMAK; Stk2; mSLK; AV021402; AW411554; mKIAA0204
    Expression
    Ubiquitous expression in bladder adult (RPKM 14.8), placenta adult (RPKM 11.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Slk in Genome Data Viewer
    Location:
    19; 19 C3- D1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (47568458..47633685)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (47580019..47645246)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (47654509..47719736)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41858 Neighboring gene STN1, CST complex subunit Neighboring gene predicted gene, 19557 Neighboring gene predicted gene 16068 Neighboring gene collagen, type XVII, alpha 1 Neighboring gene predicted gene, 26085

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytoplasmic microtubule organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of histone phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    STE20-like serine/threonine-protein kinase
    Names
    STE20-related kinase SMAK
    STE20-related serine/threonine-protein kinase
    serine/threonine-protein kinase 2
    NP_001158111.1
    NP_033315.2
    XP_006526890.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164639.1NP_001158111.1  STE20-like serine/threonine-protein kinase isoform 2

      See identical proteins and their annotated locations for NP_001158111.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC125075, AK029491, AK037798, AK051969, CD740818, CO431234
      Consensus CDS
      CCDS50465.1
      UniProtKB/Swiss-Prot
      O54988
      UniProtKB/TrEMBL
      A2RRK3
      Related
      ENSMUSP00000026043.6, ENSMUST00000026043.12
      Conserved Domains (3) summary
      smart00220
      Location:34292
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06643
      Location:28309
      STKc_SLK; Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase
      pfam12474
      Location:9871127
      PKK; Polo kinase kinase
    2. NM_009289.3NP_033315.2  STE20-like serine/threonine-protein kinase isoform 1

      See identical proteins and their annotated locations for NP_033315.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC125075, AK029491, AK037798, AK051969, CA535951, CD740818, CF748583, CO431234
      Consensus CDS
      CCDS38017.1
      UniProtKB/Swiss-Prot
      O54988
      Related
      ENSMUSP00000049977.8, ENSMUST00000051691.8
      Conserved Domains (3) summary
      smart00220
      Location:34292
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06643
      Location:28309
      STKc_SLK; Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase
      pfam12474
      Location:10181158
      PKK; Polo kinase kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      47568458..47633685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526827.5XP_006526890.1  STE20-like serine/threonine-protein kinase isoform X1

      Conserved Domains (3) summary
      PTZ00121
      Location:2841112
      PTZ00121; MAEBL; Provisional
      pfam12474
      Location:9421082
      PKK; Polo kinase kinase
      cl21453
      Location:1233
      PKc_like; Protein Kinases, catalytic domain
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