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    Slk STE20-like kinase [ Mus musculus (house mouse) ]

    Gene ID: 20874, updated on 31-Jan-2019

    Summary

    Official Symbol
    Slkprovided by MGI
    Official Full Name
    STE20-like kinaseprovided by MGI
    Primary source
    MGI:MGI:103241
    See related
    Ensembl:ENSMUSG00000025060
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9A2; Etk4; SMAK; Stk2; mSLK; AV021402; AW411554; mKIAA0204
    Expression
    Ubiquitous expression in bladder adult (RPKM 14.8), placenta adult (RPKM 11.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Slk in Genome Data Viewer
    Location:
    19; 19 C3-D1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (47580019..47645246)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (47654509..47719736)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41858 Neighboring gene predicted gene, 19557 Neighboring gene STN1, CST complex subunit Neighboring gene predicted gene 16068 Neighboring gene collagen, type XVII, alpha 1 Neighboring gene cilia and flagella associated protein 43 Neighboring gene SWI5 dependent recombination repair 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 

    Pathways from BioSystems

    • Oocyte meiosis, organism-specific biosystem (from KEGG)
      Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Oocyte meiosis, conserved biosystem (from KEGG)
      Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    activation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic microtubule organization ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of histone phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction by protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    stress-activated protein kinase signaling cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    STE20-like serine/threonine-protein kinase
    Names
    STE20-related kinase SMAK
    STE20-related serine/threonine-protein kinase
    serine/threonine-protein kinase 2
    NP_001158111.1
    NP_033315.2
    XP_006526890.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164639.1NP_001158111.1  STE20-like serine/threonine-protein kinase isoform 2

      See identical proteins and their annotated locations for NP_001158111.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC125075, AK029491, AK037798, AK051969, CD740818, CO431234
      Consensus CDS
      CCDS50465.1
      UniProtKB/Swiss-Prot
      O54988
      UniProtKB/TrEMBL
      A2RRK3
      Related
      ENSMUSP00000026043.5, ENSMUST00000026043.11
      Conserved Domains (3) summary
      smart00220
      Location:34292
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06643
      Location:28309
      STKc_SLK; Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase
      pfam12474
      Location:9871127
      PKK; Polo kinase kinase
    2. NM_009289.3NP_033315.2  STE20-like serine/threonine-protein kinase isoform 1

      See identical proteins and their annotated locations for NP_033315.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC125075, AK029491, AK037798, AK051969, CA535951, CD740818, CF748583, CO431234
      Consensus CDS
      CCDS38017.1
      UniProtKB/Swiss-Prot
      O54988
      Related
      ENSMUSP00000049977.7, ENSMUST00000051691.7
      Conserved Domains (3) summary
      smart00220
      Location:34292
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06643
      Location:28309
      STKc_SLK; Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase
      pfam12474
      Location:10181158
      PKK; Polo kinase kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      47580019..47645246
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526827.3XP_006526890.1  STE20-like serine/threonine-protein kinase isoform X1

      Conserved Domains (3) summary
      smart00220
      Location:1216
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam12474
      Location:9421082
      PKK; Polo kinase kinase
      cl21453
      Location:1233
      PKc_like; Protein Kinases, catalytic domain
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