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    Aurkc aurora kinase C [ Mus musculus (house mouse) ]

    Gene ID: 20871, updated on 17-Sep-2021

    Summary

    Official Symbol
    Aurkcprovided by MGI
    Official Full Name
    aurora kinase Cprovided by MGI
    Primary source
    MGI:MGI:1321119
    See related
    Ensembl:ENSMUSG00000070837
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI; IA; AIE1; AIK3; IAK3; Stk1; ARK-3; Stk13
    Expression
    Biased expression in testis adult (RPKM 2.8), ovary adult (RPKM 0.2) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See Aurkc in Genome Data Viewer
    Location:
    7 A1; 7 4.06 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (6998346..7006090)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (6995347..7003091)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (6948096..6955802)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 29 Neighboring gene zinc finger, imprinted 3 Neighboring gene zinc finger protein 264 Neighboring gene platelet-activating factor acetylhydrolase, isoform 1b, beta1 subunit, pseudogene 2 Neighboring gene ARP2 actin-related protein 2 homolog pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone serine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in oocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spindle midzone assembly IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of chromosome passenger complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in condensed chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in meiotic spindle midzone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in spindle midzone ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in spindle pole centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    aurora kinase C
    Names
    aurora 3
    aurora B
    aurora-related kinase 3
    aurora/IPL1-related kinase 3
    aurora/Ipl1/Eg2 protein 1
    serine/threonine kinase 13 (aurora/IPL-like)
    serine/threonine-protein kinase 13
    serine/threonine-protein kinase aurora-C
    NP_001074434.1
    NP_001074435.1
    NP_065597.2
    XP_006539760.1
    XP_006539764.1
    XP_017177568.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080965.1NP_001074434.1  aurora kinase C isoform a

      Status: VALIDATED

      Source sequence(s)
      BC100337, BG080448
      UniProtKB/TrEMBL
      E9QL04, Q497X5
      Related
      ENSMUSP00000083426.6, ENSMUST00000086248.7
      Conserved Domains (2) summary
      smart00220
      Location:55305
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:48314
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001080966.1NP_001074435.1  aurora kinase C isoform b

      See identical proteins and their annotated locations for NP_001074435.1

      Status: VALIDATED

      Source sequence(s)
      BC064780, BC100337, BG080448
      Consensus CDS
      CCDS85211.1
      UniProtKB/TrEMBL
      Q497X5, Q6P209
      Related
      ENSMUSP00000146450.2, ENSMUST00000207711.2
      Conserved Domains (1) summary
      cl21453
      Location:9275
      PKc_like; Protein Kinases, catalytic domain
    3. NM_020572.2NP_065597.2  aurora kinase C isoform b

      See identical proteins and their annotated locations for NP_065597.2

      Status: VALIDATED

      Source sequence(s)
      BC100337, BG080448, DV648982
      Consensus CDS
      CCDS85211.1
      UniProtKB/TrEMBL
      Q497X5, Q6P209
      Related
      ENSMUSP00000147207.2, ENSMUST00000208049.2
      Conserved Domains (1) summary
      cl21453
      Location:9275
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      6998346..7006090
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017322079.1XP_017177568.1  aurora kinase C isoform X1

      UniProtKB/TrEMBL
      Q6P209
      Conserved Domains (1) summary
      cl21453
      Location:9275
      PKc_like; Protein Kinases, catalytic domain
    2. XM_006539697.3XP_006539760.1  aurora kinase C isoform X1

      See identical proteins and their annotated locations for XP_006539760.1

      UniProtKB/TrEMBL
      Q6P209
      Conserved Domains (1) summary
      cl21453
      Location:9275
      PKc_like; Protein Kinases, catalytic domain
    3. XM_006539701.3XP_006539764.1  aurora kinase C isoform X1

      See identical proteins and their annotated locations for XP_006539764.1

      UniProtKB/TrEMBL
      Q6P209
      Conserved Domains (1) summary
      cl21453
      Location:9275
      PKc_like; Protein Kinases, catalytic domain
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