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    Aurkc aurora kinase C [ Mus musculus (house mouse) ]

    Gene ID: 20871, updated on 31-Jan-2019

    Summary

    Official Symbol
    Aurkcprovided by MGI
    Official Full Name
    aurora kinase Cprovided by MGI
    Primary source
    MGI:MGI:1321119
    See related
    Ensembl:ENSMUSG00000070837
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AIE1; AIK3; IAK3; ARK-3; Stk13
    Expression
    Biased expression in testis adult (RPKM 2.8), ovary adult (RPKM 0.2) and 1 other tissue See more

    Genomic context

    See Aurkc in Genome Data Viewer
    Location:
    7 A1; 7 4.06 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (6977208..7003091)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (6948096..6955802)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 29 Neighboring gene microRNA 3099 Neighboring gene zinc finger, imprinted 3 Neighboring gene platelet-activating factor acetylhydrolase, isoform 1b, beta1 subunit, pseudogene 2 Neighboring gene ARP2 actin-related protein 2 homolog pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    histone serine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    oocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    spindle midzone assembly IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome passenger complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    condensed chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    condensed nuclear chromosome, centromeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    meiotic spindle midzone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    midbody ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    spindle midzone ISO
    Inferred from Sequence Orthology
    more info
     
    spindle pole centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    aurora kinase C
    Names
    aurora 3
    aurora B
    aurora-related kinase 3
    aurora/IPL1-related kinase 3
    aurora/Ipl1/Eg2 protein 1
    serine/threonine kinase 13 (aurora/IPL-like)
    serine/threonine-protein kinase 13
    serine/threonine-protein kinase aurora-C
    NP_001074434.1
    NP_001074435.1
    NP_065597.2
    XP_006539760.1
    XP_006539764.1
    XP_011248768.1
    XP_017177568.1
    XP_017177569.1
    XP_017177570.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080965.1NP_001074434.1  aurora kinase C isoform a

      Status: VALIDATED

      Source sequence(s)
      BC100337, BG080448
      Consensus CDS
      CCDS39754.1
      UniProtKB/TrEMBL
      E9QL04, Q497X5
      Related
      ENSMUSP00000083426.5, ENSMUST00000086248.6
      Conserved Domains (2) summary
      smart00220
      Location:55305
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:48314
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001080966.1NP_001074435.1  aurora kinase C isoform b

      See identical proteins and their annotated locations for NP_001074435.1

      Status: VALIDATED

      Source sequence(s)
      BC064780, BC100337, BG080448
      Consensus CDS
      CCDS85211.1
      UniProtKB/TrEMBL
      Q497X5, Q6P209
      Related
      ENSMUSP00000146450.1, ENSMUST00000207711.1
      Conserved Domains (2) summary
      smart00220
      Location:16266
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:9275
      PKc_like; Protein Kinases, catalytic domain
    3. NM_020572.2NP_065597.2  aurora kinase C isoform b

      See identical proteins and their annotated locations for NP_065597.2

      Status: VALIDATED

      Source sequence(s)
      BC100337, BG080448, DV648982
      Consensus CDS
      CCDS85211.1
      UniProtKB/TrEMBL
      Q497X5, Q6P209
      Related
      ENSMUSP00000147207.1, ENSMUST00000208049.1
      Conserved Domains (2) summary
      smart00220
      Location:16266
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:9275
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      6977208..7003091
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017322080.1XP_017177569.1  aurora kinase C isoform X1

      UniProtKB/TrEMBL
      Q6P209
      Conserved Domains (2) summary
      smart00220
      Location:16266
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:9275
      PKc_like; Protein Kinases, catalytic domain
    2. XM_017322081.1XP_017177570.1  aurora kinase C isoform X1

      UniProtKB/TrEMBL
      Q6P209
      Conserved Domains (2) summary
      smart00220
      Location:16266
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:9275
      PKc_like; Protein Kinases, catalytic domain
    3. XM_011250466.2XP_011248768.1  aurora kinase C isoform X1

      See identical proteins and their annotated locations for XP_011248768.1

      UniProtKB/TrEMBL
      Q6P209
      Conserved Domains (2) summary
      smart00220
      Location:16266
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:9275
      PKc_like; Protein Kinases, catalytic domain
    4. XM_017322079.1XP_017177568.1  aurora kinase C isoform X1

      UniProtKB/TrEMBL
      Q6P209
      Conserved Domains (2) summary
      smart00220
      Location:16266
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:9275
      PKc_like; Protein Kinases, catalytic domain
    5. XM_006539697.3XP_006539760.1  aurora kinase C isoform X1

      See identical proteins and their annotated locations for XP_006539760.1

      UniProtKB/TrEMBL
      Q6P209
      Conserved Domains (2) summary
      smart00220
      Location:16266
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:9275
      PKc_like; Protein Kinases, catalytic domain
    6. XM_006539701.3XP_006539764.1  aurora kinase C isoform X1

      See identical proteins and their annotated locations for XP_006539764.1

      UniProtKB/TrEMBL
      Q6P209
      Conserved Domains (2) summary
      smart00220
      Location:16266
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:9275
      PKc_like; Protein Kinases, catalytic domain
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