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    Eif4g1 eukaryotic translation initiation factor 4, gamma 1 [ Mus musculus (house mouse) ]

    Gene ID: 208643, updated on 31-Jan-2019

    Summary

    Official Symbol
    Eif4g1provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 4, gamma 1provided by MGI
    Primary source
    MGI:MGI:2384784
    See related
    Ensembl:ENSMUSG00000045983
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    eIF4GI; eIF-4G1; eIF-4G 1; E030015G23Rik; eIF-4-gamma 1
    Summary
    This gene encodes a member of the eukaryotic translation initiation factors (eIF) that play important roles in translation initiation by mediating recruitment of additional initiation factors and providing a scaffold for ribosome/mRNA-bridging. Along with eIF4A and eIF4E, the encoded protein forms the eIF4F complex that bridges the 5' UTR with the polyadenylated 3' UTR resulting in mRNA circularization, enhanced translation initiation and mRNA stability. Through its association with eIF3, the encoded protein mediates recruitment of the 43S pre-initiation complex to mRNA. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes for this gene have been identified on chromosomes 2 and 13. [provided by RefSeq, Jan 2015]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 72.7), limb E14.5 (RPKM 65.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Eif4g1 in Genome Data Viewer
    Location:
    16; 16 B1
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (20672720..20692883)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (20672822..20692956)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene Neighboring gene small nucleolar RNA, C/D box 66 Neighboring gene family with sequence similarity 131, member A Neighboring gene chloride channel, voltage-sensitive 2 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide H

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC37551, MGC90776

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    eukaryotic initiation factor 4E binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    translation factor activity, RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    behavioral fear response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular macromolecule biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to nutrient levels ISO
    Inferred from Sequence Orthology
    more info
     
    energy homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cellular protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of eukaryotic translation initiation factor 4F complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mRNA cap binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of miRNA mediated inhibition of translation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of polysome binding ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of presynapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    translation ISO
    Inferred from Sequence Orthology
    more info
     
    translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    eukaryotic translation initiation factor 4F complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    eukaryotic translation initiation factor 4F complex ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    polysome ISO
    Inferred from Sequence Orthology
    more info
     
    postsynapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 4 gamma 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304432.1NP_001291361.1  eukaryotic translation initiation factor 4 gamma 1 isoform c

      See identical proteins and their annotated locations for NP_001291361.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a.
      Source sequence(s)
      BC066038, BC066103, BY789918
      Consensus CDS
      CCDS84213.1
      UniProtKB/Swiss-Prot
      Q6NZJ6
      Related
      ENSMUSP00000111123.1, ENSMUST00000115463.7
      Conserved Domains (3) summary
      cd11559
      Location:14271556
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:12281340
      MA3; MA3 domain
      pfam02854
      Location:758986
      MIF4G; MIF4G domain
    2. NM_145941.3NP_666053.2  eukaryotic translation initiation factor 4 gamma 1 isoform a

      See identical proteins and their annotated locations for NP_666053.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      BC066103, BY789918
      Consensus CDS
      CCDS28055.1
      UniProtKB/Swiss-Prot
      Q6NZJ6
      Related
      ENSMUSP00000047678.7, ENSMUST00000044783.13
      Conserved Domains (3) summary
      cd11559
      Location:14411570
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:12421354
      MA3; MA3 domain
      pfam02854
      Location:765993
      MIF4G; MIF4G domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      20672720..20692883
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521935.1XP_006521998.1  eukaryotic translation initiation factor 4 gamma 1 isoform X1

      See identical proteins and their annotated locations for XP_006521998.1

      Conserved Domains (3) summary
      cd11559
      Location:14421571
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:12431355
      MA3; MA3 domain
      pfam02854
      Location:766994
      MIF4G; MIF4G domain
    2. XM_006521937.1XP_006522000.1  eukaryotic translation initiation factor 4 gamma 1 isoform X2

      See identical proteins and their annotated locations for XP_006522000.1

      UniProtKB/Swiss-Prot
      Q6NZJ6
      Conserved Domains (3) summary
      cd11559
      Location:14411570
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:12421354
      MA3; MA3 domain
      pfam02854
      Location:765993
      MIF4G; MIF4G domain
    3. XM_011245861.1XP_011244163.1  eukaryotic translation initiation factor 4 gamma 1 isoform X5

      Conserved Domains (3) summary
      cd11559
      Location:14321561
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:12331345
      MA3; MA3 domain
      pfam02854
      Location:756984
      MIF4G; MIF4G domain
    4. XM_006521938.1XP_006522001.1  eukaryotic translation initiation factor 4 gamma 1 isoform X3

      See identical proteins and their annotated locations for XP_006522001.1

      UniProtKB/TrEMBL
      E9PVC5
      Related
      ENSMUSP00000111121.1, ENSMUST00000115461.7
      Conserved Domains (3) summary
      cd11559
      Location:14351564
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:12361348
      MA3; MA3 domain
      pfam02854
      Location:759987
      MIF4G; MIF4G domain
    5. XM_006521942.1XP_006522005.1  eukaryotic translation initiation factor 4 gamma 1 isoform X6

      Conserved Domains (3) summary
      cd11559
      Location:14251554
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:12261338
      MA3; MA3 domain
      pfam02854
      Location:749977
      MIF4G; MIF4G domain
    6. XM_006521943.1XP_006522006.1  eukaryotic translation initiation factor 4 gamma 1 isoform X7

      Conserved Domains (3) summary
      cd11559
      Location:14021531
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:12031315
      MA3; MA3 domain
      pfam02854
      Location:726954
      MIF4G; MIF4G domain
    7. XM_006521944.3XP_006522007.1  eukaryotic translation initiation factor 4 gamma 1 isoform X8

      Conserved Domains (3) summary
      cd11559
      Location:13951524
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:11961308
      MA3; MA3 domain
      pfam02854
      Location:719947
      MIF4G; MIF4G domain
    8. XM_006521939.1XP_006522002.1  eukaryotic translation initiation factor 4 gamma 1 isoform X3

      See identical proteins and their annotated locations for XP_006522002.1

      UniProtKB/TrEMBL
      E9PVC5
      Conserved Domains (3) summary
      cd11559
      Location:14351564
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:12361348
      MA3; MA3 domain
      pfam02854
      Location:759987
      MIF4G; MIF4G domain
    9. XM_006521945.1XP_006522008.1  eukaryotic translation initiation factor 4 gamma 1 isoform X9

      Conserved Domains (3) summary
      cd11559
      Location:13921521
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:11931305
      MA3; MA3 domain
      pfam02854
      Location:716944
      MIF4G; MIF4G domain
    10. XM_017316920.1XP_017172409.1  eukaryotic translation initiation factor 4 gamma 1 isoform X11

      UniProtKB/TrEMBL
      A0A0J9YUS5
      Related
      ENSMUSP00000144320.1, ENSMUST00000143939.7
    11. XM_006521946.1XP_006522009.1  eukaryotic translation initiation factor 4 gamma 1 isoform X10

      Conserved Domains (3) summary
      cd11559
      Location:13481477
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:11491261
      MA3; MA3 domain
      pfam02854
      Location:672900
      MIF4G; MIF4G domain
    12. XM_006521940.3XP_006522003.1  eukaryotic translation initiation factor 4 gamma 1 isoform X4

      UniProtKB/TrEMBL
      E9Q9E1
      Related
      ENSMUSP00000073506.5, ENSMUST00000073840.11
      Conserved Domains (3) summary
      cd11559
      Location:14341563
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:12351347
      MA3; MA3 domain
      pfam02854
      Location:758986
      MIF4G; MIF4G domain
    13. XM_006521936.2XP_006521999.1  eukaryotic translation initiation factor 4 gamma 1 isoform X1

      See identical proteins and their annotated locations for XP_006521999.1

      Conserved Domains (3) summary
      cd11559
      Location:14421571
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:12431355
      MA3; MA3 domain
      pfam02854
      Location:766994
      MIF4G; MIF4G domain
    14. XM_017316919.1XP_017172408.1  eukaryotic translation initiation factor 4 gamma 1 isoform X7

      Conserved Domains (3) summary
      cd11559
      Location:14021531
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:12031315
      MA3; MA3 domain
      pfam02854
      Location:726954
      MIF4G; MIF4G domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001005331.1: Suppressed sequence

      Description
      NM_001005331.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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