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    Kntc1 kinetochore associated 1 [ Mus musculus (house mouse) ]

    Gene ID: 208628, updated on 22-Aug-2021

    Summary

    Official Symbol
    Kntc1provided by MGI
    Official Full Name
    kinetochore associated 1provided by MGI
    Primary source
    MGI:MGI:2673709
    See related
    Ensembl:ENSMUSG00000029414
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    jg; jgl; D330012D13
    Expression
    Biased expression in CNS E11.5 (RPKM 6.8), liver E14 (RPKM 6.3) and 14 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Kntc1 in Genome Data Viewer
    Location:
    5; 5 F
    Exon count:
    67
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (123887755..123959656)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (123749692..123821593)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (124199735..124271602)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene polymerase (RNA) II (DNA directed) polypeptide K pseudogene Neighboring gene arginine/serine-rich coiled-coil 2 Neighboring gene hydroxycarboxylic acid receptor 2 Neighboring gene hydrocarboxylic acid receptor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (1) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mitotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mitotic spindle assembly checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to kinetochore involved in kinetochore assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RZZ complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of RZZ complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in kinetochore microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in kinetochore microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    kinetochore-associated protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042421.1NP_001035886.1  kinetochore-associated protein 1

      See identical proteins and their annotated locations for NP_001035886.1

      Status: VALIDATED

      Source sequence(s)
      AC129582, AK172905, BY010626
      Consensus CDS
      CCDS39274.1
      UniProtKB/Swiss-Prot
      Q8C3Y4
      Related
      ENSMUSP00000031366.8, ENSMUST00000031366.12
      Conserved Domains (1) summary
      pfam10493
      Location:15822126
      Rod_C; Rough deal protein C-terminal region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      123887755..123959656
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530253.5XP_006530316.1  kinetochore-associated protein 1 isoform X5

    2. XM_006530252.5XP_006530315.1  kinetochore-associated protein 1 isoform X4

    3. XM_006530250.4XP_006530313.1  kinetochore-associated protein 1 isoform X2

      Conserved Domains (1) summary
      pfam10493
      Location:15791962
      Rod_C; Rough deal protein C-terminal region
    4. XM_030254330.1XP_030110190.1  kinetochore-associated protein 1 isoform X1

      Conserved Domains (1) summary
      pfam10493
      Location:14271976
      Rod_C; Rough deal protein C-terminal region
    5. XM_006530251.4XP_006530314.1  kinetochore-associated protein 1 isoform X3

      Conserved Domains (1) summary
      pfam10493
      Location:7761325
      Rod_C; Rough deal protein C-terminal region
    6. XM_006530254.2XP_006530317.1  kinetochore-associated protein 1 isoform X6

      Conserved Domains (1) summary
      pfam10493
      Location:6731222
      Rod_C; Rough deal protein C-terminal region
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