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    Cep78 centrosomal protein 78 [ Mus musculus (house mouse) ]

    Gene ID: 208518, updated on 24-Apr-2022

    Summary

    Official Symbol
    Cep78provided by MGI
    Official Full Name
    centrosomal protein 78provided by MGI
    Primary source
    MGI:MGI:1924386
    See related
    Ensembl:ENSMUSG00000041491 AllianceGenome:MGI:1924386
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D030027P05; 5730599I05Rik
    Summary
    Predicted to be involved in cilium organization. Predicted to act upstream of or within cell projection organization. Predicted to be located in centriole and ciliary basal body. Predicted to be active in centrosome. Is expressed in eye. Orthologous to human CEP78 (centrosomal protein 78). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 11.0), CNS E14 (RPKM 7.9) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cep78 in Genome Data Viewer
    Location:
    19; 19 A
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (15933134..15962396, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (15955768..15985700, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (16030263..16059479, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54054 Neighboring gene predicted gene, 24319 Neighboring gene phosphoserine aminotransferase 1 Neighboring gene RIKEN cDNA C130060C02 gene Neighboring gene ribosomal protein 37, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cilium organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    centrosomal protein of 78 kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198019.2NP_932136.2  centrosomal protein of 78 kDa

      See identical proteins and their annotated locations for NP_932136.2

      Status: VALIDATED

      Source sequence(s)
      BC070400
      Consensus CDS
      CCDS29682.1
      UniProtKB/Swiss-Prot
      Q6IRU7
      Related
      ENSMUSP00000037596.8, ENSMUST00000047704.8
      Conserved Domains (2) summary
      cd00116
      Location:113299
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cl03075
      Location:431498
      GrpE; nucleotide exchange factor GrpE

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      15933134..15962396 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526825.5XP_006526888.1  centrosomal protein of 78 kDa isoform X6

      Conserved Domains (2) summary
      cl03075
      Location:431498
      GrpE; nucleotide exchange factor GrpE
      cl39015
      Location:113299
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    2. XM_006526823.3XP_006526886.1  centrosomal protein of 78 kDa isoform X1

      Conserved Domains (1) summary
      cl39015
      Location:113299
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    3. XM_036161498.1XP_036017391.1  centrosomal protein of 78 kDa isoform X2

      Conserved Domains (1) summary
      cl39015
      Location:113299
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    4. XM_006526826.5XP_006526889.1  centrosomal protein of 78 kDa isoform X5

      Conserved Domains (2) summary
      cl03075
      Location:231298
      GrpE; nucleotide exchange factor GrpE
      cl39015
      Location:45103
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    5. XM_006526824.3XP_006526887.1  centrosomal protein of 78 kDa isoform X3

      Conserved Domains (1) summary
      cl39015
      Location:113299
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    6. XM_017318106.3XP_017173595.1  centrosomal protein of 78 kDa isoform X4

      Related
      ENSMUSP00000157915.2, ENSMUST00000235718.2
      Conserved Domains (2) summary
      cl03075
      Location:431498
      GrpE; nucleotide exchange factor GrpE
      cl39015
      Location:113299
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    7. XM_030250838.2XP_030106698.1  centrosomal protein of 78 kDa isoform X7

      Conserved Domains (2) summary
      cl03075
      Location:231298
      GrpE; nucleotide exchange factor GrpE
      cl39015
      Location:45103
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...