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    Stat2 signal transducer and activator of transcription 2 [ Mus musculus (house mouse) ]

    Gene ID: 20847, updated on 6-Nov-2018

    Summary

    Official Symbol
    Stat2provided by MGI
    Official Full Name
    signal transducer and activator of transcription 2provided by MGI
    Primary source
    MGI:MGI:103039
    See related
    Ensembl:ENSMUSG00000040033
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AW496480; 1600010G07Rik
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 14.3), thymus adult (RPKM 11.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Stat2 in Genome Data Viewer
    Location:
    10 D3; 10 76.5 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (128270559..128292852)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (127707632..127729905)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene apolipoprotein N Neighboring gene apolipoprotein F Neighboring gene interleukin 23, alpha subunit p19 Neighboring gene PAN2 poly(A) specific ribonuclease subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Adipogenesis genes, organism-specific biosystem (from WikiPathways)
      Adipogenesis genes, organism-specific biosystemThe different classes of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compos...
    • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
      Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chemokine signaling pathway, conserved biosystem (from KEGG)
      Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chemokine signaling pathway, organism-specific biosystem (from WikiPathways)
      Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Hepatitis B, organism-specific biosystem (from KEGG)
      Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
    • Hepatitis C, organism-specific biosystem (from KEGG)
      Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Hepatitis C, conserved biosystem (from KEGG)
      Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Interferon alpha/beta signaling, organism-specific biosystem (from REACTOME)
      Interferon alpha/beta signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • JAK-STAT signaling, organism-specific biosystem (from KEGG)
      JAK-STAT signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
    • JAK-STAT signaling, conserved biosystem (from KEGG)
      JAK-STAT signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
      NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • Osteoclast differentiation, organism-specific biosystem (from KEGG)
      Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Osteoclast differentiation, conserved biosystem (from KEGG)
      Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Regulation of IFNA signaling, organism-specific biosystem (from REACTOME)
      Regulation of IFNA signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Type II interferon signaling (IFNG), organism-specific biosystem (from WikiPathways)
      Type II interferon signaling (IFNG), organism-specific biosystemAdapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin-like protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    type I interferon signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    type I interferon signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    signal transducer and activator of transcription 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019963.2NP_064347.1  signal transducer and activator of transcription 2

      See identical proteins and their annotated locations for NP_064347.1

      Status: VALIDATED

      Source sequence(s)
      AC135859
      Consensus CDS
      CCDS24269.1
      UniProtKB/TrEMBL
      Q9QXJ2
      Related
      ENSMUSP00000082855.2, ENSMUST00000085708.2
      Conserved Domains (6) summary
      pfam05887
      Location:742820
      Trypan_PARP; Procyclic acidic repetitive protein (PARP)
      cd10373
      Location:554704
      SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
      smart00964
      Location:2123
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:141314
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:316563
      STAT_bind; STAT protein, DNA binding domain
      pfam12188
      Location:853907
      STAT2_C; Signal transducer and activator of transcription 2 C terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      128270559..128292852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513433.1XP_006513496.1  signal transducer and activator of transcription 2 isoform X1

      Conserved Domains (6) summary
      pfam05887
      Location:745823
      Trypan_PARP; Procyclic acidic repetitive protein (PARP)
      cd10373
      Location:557707
      SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
      smart00964
      Location:2123
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:141314
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:316566
      STAT_bind; STAT protein, DNA binding domain
      pfam12188
      Location:856910
      STAT2_C; Signal transducer and activator of transcription 2 C terminal
    2. XM_006513436.1XP_006513499.1  signal transducer and activator of transcription 2 isoform X3

      Conserved Domains (4) summary
      smart00964
      Location:2123
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:141314
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:316566
      STAT_bind; STAT protein, DNA binding domain
      cl15255
      Location:557623
      SH2; Src homology 2 (SH2) domain
    3. XM_006513435.1XP_006513498.1  signal transducer and activator of transcription 2 isoform X2

      Conserved Domains (6) summary
      pfam05887
      Location:715793
      Trypan_PARP; Procyclic acidic repetitive protein (PARP)
      cd10373
      Location:527677
      SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
      smart00964
      Location:2123
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:114284
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:286536
      STAT_bind; STAT protein, DNA binding domain
      pfam12188
      Location:826880
      STAT2_C; Signal transducer and activator of transcription 2 C terminal
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