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    Stag2 stromal antigen 2 [ Mus musculus (house mouse) ]

    Gene ID: 20843, updated on 3-Oct-2018

    Summary

    Official Symbol
    Stag2provided by MGI
    Official Full Name
    stromal antigen 2provided by MGI
    Primary source
    MGI:MGI:1098583
    See related
    Ensembl:ENSMUSG00000025862 Vega:OTTMUSG00000017467
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SA-2; SAP2; 9230105L23Rik; B230112I07Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 11.4), liver E14 (RPKM 10.4) and 24 other tissues See more
    Orthologs

    Genomic context

    See Stag2 in Genome Data Viewer
    Location:
    X; X A4
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (42149319..42277186)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (39502589..39630352)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene X-linked inhibitor of apoptosis Neighboring gene zinc finger protein 7 pseudogene Neighboring gene RIKEN cDNA B230118I11 gene Neighboring gene TEX13 family member D

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
     
    meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of DNA endoreduplication ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
     
    stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    cohesin complex ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cohesin subunit SA-2
    Names
    SCC3 homolog 2
    nuclear protein SA2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077712.2NP_001071180.1  cohesin subunit SA-2 isoform 1

      See identical proteins and their annotated locations for NP_001071180.1

      Status: VALIDATED

      Source sequence(s)
      AA461826, AK161072, AL672089, BC066041, CN669441, CO434048
      Consensus CDS
      CCDS40952.1
      UniProtKB/Swiss-Prot
      O35638
      Related
      ENSMUSP00000110724.1, ENSMUST00000115072.7
      Conserved Domains (1) summary
      pfam08514
      Location:157265
      STAG; STAG domain
    2. NM_001290713.2NP_001277642.1  cohesin subunit SA-2 isoform 2

      See identical proteins and their annotated locations for NP_001277642.1

      Status: VALIDATED

      Source sequence(s)
      AA461826, AK161072, AL672089, BC066041, CN708963, CO434048
      Consensus CDS
      CCDS72371.1
      UniProtKB/TrEMBL
      A2AFF6
      Conserved Domains (2) summary
      pfam08514
      Location:157265
      STAG; STAG domain
      cl21454
      Location:116145
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    3. NM_001358225.1NP_001345154.1  cohesin subunit SA-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AA461826, AL672089
      Conserved Domains (1) summary
      pfam08514
      Location:157265
      STAG; STAG domain
    4. NM_021465.4NP_067440.3  cohesin subunit SA-2 isoform 1

      See identical proteins and their annotated locations for NP_067440.3

      Status: VALIDATED

      Source sequence(s)
      AA461826, AK146718, AK161072, BC066041, CO434048
      Consensus CDS
      CCDS40952.1
      UniProtKB/Swiss-Prot
      O35638
      UniProtKB/TrEMBL
      Q3TG33
      Related
      ENSMUSP00000063250.7, OTTMUSP00000019064, ENSMUST00000069619.13, OTTMUST00000042416
      Conserved Domains (1) summary
      pfam08514
      Location:157265
      STAG; STAG domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      42149319..42277186
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250984.2XP_011249286.1  cohesin subunit SA-2 isoform X1

      See identical proteins and their annotated locations for XP_011249286.1

      UniProtKB/TrEMBL
      A2AFF6
      Related
      ENSMUSP00000110725.2, OTTMUSP00000019065, ENSMUST00000115073.8, OTTMUST00000042417
      Conserved Domains (2) summary
      pfam08514
      Location:157265
      STAG; STAG domain
      cl21454
      Location:116145
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    2. XM_017318446.1XP_017173935.1  cohesin subunit SA-2 isoform X2

      UniProtKB/Swiss-Prot
      O35638
      Conserved Domains (1) summary
      pfam08514
      Location:157265
      STAG; STAG domain
    3. XM_011250987.1XP_011249289.1  cohesin subunit SA-2 isoform X1

      See identical proteins and their annotated locations for XP_011249289.1

      UniProtKB/TrEMBL
      A2AFF6
      Conserved Domains (2) summary
      pfam08514
      Location:157265
      STAG; STAG domain
      cl21454
      Location:116145
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    4. XM_011250985.2XP_011249287.1  cohesin subunit SA-2 isoform X1

      See identical proteins and their annotated locations for XP_011249287.1

      UniProtKB/TrEMBL
      A2AFF6
      Conserved Domains (2) summary
      pfam08514
      Location:157265
      STAG; STAG domain
      cl21454
      Location:116145
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    5. XM_011250989.2XP_011249291.1  cohesin subunit SA-2 isoform X2

      See identical proteins and their annotated locations for XP_011249291.1

      UniProtKB/Swiss-Prot
      O35638
      Conserved Domains (1) summary
      pfam08514
      Location:157265
      STAG; STAG domain
    6. XM_011250986.2XP_011249288.1  cohesin subunit SA-2 isoform X1

      UniProtKB/TrEMBL
      A2AFF6
      Conserved Domains (2) summary
      pfam08514
      Location:157265
      STAG; STAG domain
      cl21454
      Location:116145
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    7. XM_011250983.2XP_011249285.1  cohesin subunit SA-2 isoform X1

      See identical proteins and their annotated locations for XP_011249285.1

      UniProtKB/TrEMBL
      A2AFF6
      Conserved Domains (2) summary
      pfam08514
      Location:157265
      STAG; STAG domain
      cl21454
      Location:116145
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    8. XM_011250988.1XP_011249290.1  cohesin subunit SA-2 isoform X1

      See identical proteins and their annotated locations for XP_011249290.1

      UniProtKB/TrEMBL
      A2AFF6
      Conserved Domains (2) summary
      pfam08514
      Location:157265
      STAG; STAG domain
      cl21454
      Location:116145
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
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