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    Dot1l DOT1-like, histone H3 methyltransferase (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 208266, updated on 12-Sep-2021

    Summary

    Official Symbol
    Dot1lprovided by MGI
    Official Full Name
    DOT1-like, histone H3 methyltransferase (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:2143886
    See related
    Ensembl:ENSMUSG00000061589
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dot1; KMT4; mDot; mDot1; AW907654; A630076O07
    Expression
    Ubiquitous expression in testis adult (RPKM 34.5), adrenal adult (RPKM 27.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Dot1l in Genome Data Viewer
    Location:
    10; 10 C1
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80590935..80631295)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80755101..80795461)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (80217951..80257092)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene adaptor-related protein complex 3, delta 1 subunit Neighboring gene predicted gene, 53592 Neighboring gene VISTA enhancer mm200 Neighboring gene pleckstrin homology domain containing, family J member 1 Neighboring gene splicing factor 3a, subunit 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables histone methyltransferase activity (H3-K79 specific) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables histone-lysine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    histone-lysine N-methyltransferase, H3 lysine-79 specific
    Names
    DOT1-like histone H3 methyltransferase
    histone H3 methyltransferase DOT1
    histone methyltransferase DOT1L
    NP_955354.1
    XP_006513492.1
    XP_006513493.1
    XP_006513494.1
    XP_011241692.1
    XP_011241693.1
    XP_030100834.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199322.2NP_955354.1  histone-lysine N-methyltransferase, H3 lysine-79 specific

      See identical proteins and their annotated locations for NP_955354.1

      Status: VALIDATED

      Source sequence(s)
      AC166937, AW123461, AY196089, CJ104249
      Consensus CDS
      CCDS35985.1
      UniProtKB/TrEMBL
      Q6XZL8
      Related
      ENSMUSP00000100973.3, ENSMUST00000105336.9
      Conserved Domains (3) summary
      pfam08123
      Location:115317
      DOT1; Histone methylation protein DOT1
      pfam15035
      Location:491659
      Rootletin; Ciliary rootlet component, centrosome cohesion
      pfam15898
      Location:573630
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80590935..80631295
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243391.3XP_011241693.1  histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X2

      Conserved Domains (4) summary
      pfam08123
      Location:115317
      DOT1; Histone methylation protein DOT1
      PHA03307
      Location:7811125
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR04523
      Location:510659
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam05109
      Location:9421314
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    2. XM_011243390.3XP_011241692.1  histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1

      See identical proteins and their annotated locations for XP_011241692.1

      Conserved Domains (4) summary
      pfam08123
      Location:115317
      DOT1; Histone methylation protein DOT1
      PHA03307
      Location:7811125
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR04523
      Location:510659
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam05109
      Location:9421314
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    3. XM_006513429.4XP_006513492.1  histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1

      See identical proteins and their annotated locations for XP_006513492.1

      Conserved Domains (4) summary
      pfam08123
      Location:115317
      DOT1; Histone methylation protein DOT1
      PHA03307
      Location:7811125
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR04523
      Location:510659
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam05109
      Location:9421314
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    4. XM_006513430.3XP_006513493.1  histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X4

      See identical proteins and their annotated locations for XP_006513493.1

      Conserved Domains (3) summary
      PHA03307
      Location:542886
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR04523
      Location:271420
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      cl17173
      Location:978
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    5. XM_030244974.2XP_030100834.1  histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X3

      Conserved Domains (3) summary
      PHA03307
      Location:565909
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR04523
      Location:294443
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      cl17173
      Location:2101
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    6. XM_006513431.3XP_006513494.1  histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X4

      See identical proteins and their annotated locations for XP_006513494.1

      Conserved Domains (3) summary
      PHA03307
      Location:542886
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR04523
      Location:271420
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      cl17173
      Location:978
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RNA

    1. XR_380380.4 RNA Sequence

    2. XR_004936134.1 RNA Sequence

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