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    Dot1l DOT1-like, histone H3 methyltransferase (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 208266, updated on 12-Aug-2018

    Summary

    Official Symbol
    Dot1lprovided by MGI
    Official Full Name
    DOT1-like, histone H3 methyltransferase (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:2143886
    See related
    Ensembl:ENSMUSG00000061589 Vega:OTTMUSG00000017289
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dot1; KMT4; mDot1; AW907654; A630076O07
    Expression
    Ubiquitous expression in testis adult (RPKM 34.5), adrenal adult (RPKM 27.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Dot1l in Genome Data Viewer
    Location:
    10; 10 C1
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (80755130..80795461)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (80217951..80257092)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene IZUMO family member 4 Neighboring gene adaptor-related protein complex 3, delta 1 subunit Neighboring gene pleckstrin homology domain containing, family J member 1 Neighboring gene splicing factor 3a, subunit 2 Neighboring gene anti-Mullerian hormone

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    histone methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    histone methyltransferase activity (H3-K79 specific) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone-lysine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA damage checkpoint IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chromatin silencing at telomere IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone H3-K79 methylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of JAK-STAT cascade ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription regulatory region DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    histone-lysine N-methyltransferase, H3 lysine-79 specific
    Names
    DOT1-like histone H3 methyltransferase
    histone H3 methyltransferase DOT1
    histone methyltransferase DOT1L
    NP_955354.1
    XP_006513492.1
    XP_006513493.1
    XP_006513494.1
    XP_006513495.1
    XP_011241692.1
    XP_011241693.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199322.2NP_955354.1  histone-lysine N-methyltransferase, H3 lysine-79 specific

      See identical proteins and their annotated locations for NP_955354.1

      Status: VALIDATED

      Source sequence(s)
      AC166937, AW123461, AY196089, CJ104249
      Consensus CDS
      CCDS35985.1
      UniProtKB/TrEMBL
      Q6XZL8
      Related
      ENSMUSP00000100973.2, OTTMUSP00000018849, ENSMUST00000105336.8
      Conserved Domains (3) summary
      pfam08123
      Location:115317
      DOT1; Histone methylation protein DOT1
      pfam15035
      Location:491659
      Rootletin; Ciliary rootlet component, centrosome cohesion
      pfam15898
      Location:573630
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      80755130..80795461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243391.2XP_011241693.1  histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X2

      Conserved Domains (3) summary
      pfam08123
      Location:115317
      DOT1; Histone methylation protein DOT1
      pfam15035
      Location:491659
      Rootletin; Ciliary rootlet component, centrosome cohesion
      pfam15898
      Location:573630
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
    2. XM_011243390.2XP_011241692.1  histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1

      See identical proteins and their annotated locations for XP_011241692.1

      Conserved Domains (4) summary
      pfam08123
      Location:115317
      DOT1; Histone methylation protein DOT1
      pfam12474
      Location:535652
      PKK; Polo kinase kinase
      pfam15035
      Location:491659
      Rootletin; Ciliary rootlet component, centrosome cohesion
      pfam15898
      Location:573630
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
    3. XM_006513429.3XP_006513492.1  histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1

      See identical proteins and their annotated locations for XP_006513492.1

      Conserved Domains (4) summary
      pfam08123
      Location:115317
      DOT1; Histone methylation protein DOT1
      pfam12474
      Location:535652
      PKK; Polo kinase kinase
      pfam15035
      Location:491659
      Rootletin; Ciliary rootlet component, centrosome cohesion
      pfam15898
      Location:573630
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
    4. XM_006513432.3XP_006513495.1  histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X4

      Conserved Domains (5) summary
      pfam12474
      Location:319436
      PKK; Polo kinase kinase
      pfam15898
      Location:357414
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      cl17173
      Location:2101
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      cl23718
      Location:234257
      ALP_like; alkaline phosphatases and sulfatases
      cl23720
      Location:296417
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    5. XM_006513431.1XP_006513494.1  histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X3

      See identical proteins and their annotated locations for XP_006513494.1

      Conserved Domains (4) summary
      pfam12474
      Location:296413
      PKK; Polo kinase kinase
      pfam15035
      Location:252420
      Rootletin; Ciliary rootlet component, centrosome cohesion
      pfam15898
      Location:334391
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      cl17173
      Location:978
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    6. XM_006513430.1XP_006513493.1  histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X3

      See identical proteins and their annotated locations for XP_006513493.1

      Conserved Domains (4) summary
      pfam12474
      Location:296413
      PKK; Polo kinase kinase
      pfam15035
      Location:252420
      Rootletin; Ciliary rootlet component, centrosome cohesion
      pfam15898
      Location:334391
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      cl17173
      Location:978
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RNA

    1. XR_380380.3 RNA Sequence

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