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    Vcpkmt valosin containing protein lysine (K) methyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 207965, updated on 24-Apr-2022

    Summary

    Official Symbol
    Vcpkmtprovided by MGI
    Official Full Name
    valosin containing protein lysine (K) methyltransferaseprovided by MGI
    Primary source
    MGI:MGI:2684917
    See related
    Ensembl:ENSMUSG00000049882 AllianceGenome:MGI:2684917
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm71; VCP-KMT; Mettl21d; Mettl221d
    Summary
    Predicted to enable ATPase binding activity and protein-lysine N-methyltransferase activity. Predicted to be involved in negative regulation of ATPase activity and peptidyl-lysine trimethylation. Predicted to act upstream of or within methylation. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Orthologous to human VCPKMT (valosin containing protein lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 4.9), cerebellum adult (RPKM 4.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Vcpkmt in Genome Data Viewer
    Location:
    12; 12 C2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (69623504..69629883, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (69576735..69583017, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (70678615..70684015, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31512 Neighboring gene predicted gene, 46353 Neighboring gene predicted gene, 24449 Neighboring gene SOS Ras/Rho guanine nucleotide exchange factor 2 Neighboring gene predicted gene, 31679

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein-lysine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein-lysine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of ATP-dependent activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-lysine methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in peptidyl-lysine methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-lysine trimethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in peptidyl-lysine trimethylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-lysine trimethylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein N-lysine methyltransferase METTL21D; protein-lysine methyltransferase METTL21D
    Names
    VCP lysine methyltransferase
    methyltransferase like 21D
    methyltransferase-like protein 21D
    valosin-containing protein lysine methyltransferase

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033236.3NP_001028408.2  protein N-lysine methyltransferase METTL21D isoform 2

      See identical proteins and their annotated locations for NP_001028408.2

      Status: VALIDATED

      Source sequence(s)
      AC153658
      Consensus CDS
      CCDS36464.1
      UniProtKB/Swiss-Prot
      Q8C436
      Related
      ENSMUSP00000055002.10, ENSMUST00000058639.11
      Conserved Domains (1) summary
      pfam10294
      Location:22194
      Methyltransf_16; Lysine methyltransferase
    2. NM_001379044.1NP_001365973.1  protein N-lysine methyltransferase METTL21D isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC153658
      Conserved Domains (1) summary
      pfam10294
      Location:22194
      Methyltransf_16; Lysine methyltransferase

    RNA

    1. NR_166433.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153658
    2. NR_166434.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153658
    3. NR_166435.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153658
    4. NR_166437.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153658

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      69623504..69629883 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157295.1XP_036013188.1  protein-lysine methyltransferase METTL21D isoform X1

      Conserved Domains (1) summary
      pfam10294
      Location:54226
      Methyltransf_16; Lysine methyltransferase

    RNA

    1. XR_004937479.1 RNA Sequence

      Related
      ENSMUST00000238220.2