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    Vcpkmt valosin containing protein lysine (K) methyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 207965, updated on 11-Mar-2018

    Summary

    Official Symbol
    Vcpkmtprovided by MGI
    Official Full Name
    valosin containing protein lysine (K) methyltransferaseprovided by MGI
    Primary source
    MGI:MGI:2684917
    See related
    Ensembl:ENSMUSG00000049882
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm71; VCP-KMT; Mettl21d; Mettl221d
    Expression
    Ubiquitous expression in CNS E18 (RPKM 4.9), cerebellum adult (RPKM 4.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Vcpkmt in Genome Data Viewer
    Location:
    12; 12 C2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (69576730..69583109, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (70678615..70684015, complement)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 31512 Neighboring gene predicted gene, 46353 Neighboring gene SOS Ras/Rho guanine nucleotide exchange factor 2 Neighboring gene predicted gene, 31679 Neighboring gene chloride intracellular channel protein 4 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein-lysine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    methylation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-lysine methylation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-lysine trimethylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein-lysine methyltransferase METTL21D
    Names
    VCP lysine methyltransferase
    methyltransferase like 21D
    methyltransferase-like protein 21D
    valosin-containing protein lysine methyltransferase

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033236.2NP_001028408.2  protein-lysine methyltransferase METTL21D

      See identical proteins and their annotated locations for NP_001028408.2

      Status: VALIDATED

      Source sequence(s)
      AC153658, AK144832, BY095246
      Consensus CDS
      CCDS36464.1
      UniProtKB/Swiss-Prot
      Q8C436
      Related
      ENSMUSP00000055002.9, ENSMUST00000058639.9
      Conserved Domains (1) summary
      pfam10294
      Location:22194
      Methyltransf_16; Lysine methyltransferase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      69576730..69583109 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244052.1XP_011242354.1  protein-lysine methyltransferase METTL21D isoform X1

      Conserved Domains (1) summary
      pfam10294
      Location:54226
      Methyltransf_16; Lysine methyltransferase

    RNA

    1. XR_381512.2 RNA Sequence

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