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    Esrp1 epithelial splicing regulatory protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 207920, updated on 16-Oct-2021

    Summary

    Official Symbol
    Esrp1provided by MGI
    Official Full Name
    epithelial splicing regulatory protein 1provided by MGI
    Primary source
    MGI:MGI:1917326
    See related
    Ensembl:ENSMUSG00000040728
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rbm35a; BC031468; A630065D16; 2210008M09Rik
    Expression
    Biased expression in colon adult (RPKM 18.2), large intestine adult (RPKM 15.6) and 14 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Esrp1 in Genome Data Viewer
    Location:
    4; 4 A1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (11331933..11386783, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (11331933..11386783, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (11259185..11313930, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene cyclin E2 Neighboring gene integrator complex subunit 8 Neighboring gene dpy-19-like 4 (C. elegans) Neighboring gene ES cell cis-regulatory motif 9a Neighboring gene predicted gene, 35631

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC25805

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    epithelial splicing regulatory protein 1
    Names
    RNA binding motif protein 35A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290383.1NP_001277312.1  epithelial splicing regulatory protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001277312.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter by an amino acid, compared to isoform 1.
      Source sequence(s)
      AA647208, AK140848, CJ081693, DV648780, DV654302, DV657411
      UniProtKB/Swiss-Prot
      Q3US41
      Conserved Domains (6) summary
      COG0724
      Location:284472
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12736
      Location:220304
      RRM1_ESRP1; RNA recognition motif 1 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
      cd12739
      Location:309417
      RRM2_ESRP1; RNA recognition motif 2 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
      cd12742
      Location:443523
      RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
      cl10012
      Location:29145
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
      cl17169
      Location:633671
      RRM_SF; RNA recognition motif (RRM) superfamily
    2. NM_001347052.1NP_001333981.1  epithelial splicing regulatory protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction in the 3' end and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL772170
      Consensus CDS
      CCDS84703.1
      UniProtKB/Swiss-Prot
      Q3US41
      Related
      ENSMUSP00000103949.2, ENSMUST00000108313.8
    3. NM_194055.3NP_918944.2  epithelial splicing regulatory protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA647208, AK042164, AK140848, CJ081693, DV648780, DV657411
      Consensus CDS
      CCDS51119.1
      UniProtKB/Swiss-Prot
      Q3US41
      UniProtKB/TrEMBL
      F8WGU3
      Related
      ENSMUSP00000103947.3, ENSMUST00000108311.9
      Conserved Domains (6) summary
      COG0724
      Location:285473
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12736
      Location:221305
      RRM1_ESRP1; RNA recognition motif 1 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
      cd12739
      Location:310418
      RRM2_ESRP1; RNA recognition motif 2 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
      cd12742
      Location:444524
      RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
      cl10012
      Location:29145
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
      cl17169
      Location:634672
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      11331933..11386783 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537715.1XP_006537778.1  epithelial splicing regulatory protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3US41
      Related
      ENSMUSP00000103946.2, ENSMUST00000108310.8
      Conserved Domains (6) summary
      cd12736
      Location:221305
      RRM1_ESRP1; RNA recognition motif 1 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
      cd12739
      Location:310418
      RRM2_ESRP1; RNA recognition motif 2 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
      cd12742
      Location:444524
      RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
      pfam16072
      Location:556631
      DUF4813; Domain of unknown function (DUF4813)
      cl10012
      Location:29145
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
      cl17169
      Location:630668
      RRM_SF; RNA recognition motif (RRM) superfamily
    2. XM_006537718.1XP_006537781.1  epithelial splicing regulatory protein 1 isoform X4

      UniProtKB/Swiss-Prot
      Q3US41
      Conserved Domains (4) summary
      cd12736
      Location:221305
      RRM1_ESRP1; RNA recognition motif 1 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
      cd12739
      Location:310418
      RRM2_ESRP1; RNA recognition motif 2 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
      cd12742
      Location:444524
      RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
      cl10012
      Location:29145
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    3. XM_006537717.1XP_006537780.1  epithelial splicing regulatory protein 1 isoform X3

      Conserved Domains (4) summary
      cd12736
      Location:221305
      RRM1_ESRP1; RNA recognition motif 1 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
      cd12739
      Location:310418
      RRM2_ESRP1; RNA recognition motif 2 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
      cd12742
      Location:444524
      RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
      cl10012
      Location:29145
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    4. XM_006537716.1XP_006537779.1  epithelial splicing regulatory protein 1 isoform X2

      Related
      ENSMUSP00000037921.8, ENSMUST00000043781.14
      Conserved Domains (6) summary
      cd12736
      Location:221305
      RRM1_ESRP1; RNA recognition motif 1 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
      cd12739
      Location:310418
      RRM2_ESRP1; RNA recognition motif 2 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
      cd12742
      Location:444524
      RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
      pfam04625
      Location:541632
      DEC-1_N; DEC-1 protein, N-terminal region
      cl10012
      Location:29145
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
      cl17169
      Location:634661
      RRM_SF; RNA recognition motif (RRM) superfamily

    RNA

    1. XR_003954898.1 RNA Sequence

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