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    Fchsd2 FCH and double SH3 domains 2 [ Mus musculus (house mouse) ]

    Gene ID: 207278, updated on 23-Jun-2021

    Summary

    Official Symbol
    Fchsd2provided by MGI
    Official Full Name
    FCH and double SH3 domains 2provided by MGI
    Primary source
    MGI:MGI:2448475
    See related
    Ensembl:ENSMUSG00000030691
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NWK1; Sh3md; R74866; Sh3md3; BC034086; mKIAA0769
    Expression
    Ubiquitous expression in CNS E18 (RPKM 15.4), whole brain E14.5 (RPKM 12.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Fchsd2 in Genome Data Viewer
    Location:
    7; 7 E2
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (100757836..100933613)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (101108499..101284405)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (108257289..108432919)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2Y, G-protein coupled 2 Neighboring gene ribosomal protein S29 pseudogene Neighboring gene ribosomal protein L27 pseudogene Neighboring gene predicted gene, 47324 Neighboring gene uncharacterized LOC115486538 Neighboring gene predicted gene, 50587 Neighboring gene autophagy related 16-like 2 (S. cerevisiae) Neighboring gene START domain containing 10 Neighboring gene predicted gene 20476

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-3,4-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in neuromuscular junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in stereocilium shaft IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    F-BAR and double SH3 domains protein 2
    Names
    FCH and double SH3 domains protein 2
    SH3 multiple domains 3
    SH3 multiple domains protein 3
    protein nervous wreck 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146010.1NP_001139482.1  F-BAR and double SH3 domains protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001139482.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the mid coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AK140322, AK141949, BC060647
      Consensus CDS
      CCDS52328.1
      UniProtKB/Swiss-Prot
      Q3USJ8
      Related
      ENSMUSP00000095850.4, ENSMUST00000098250.10
      Conserved Domains (3) summary
      cd07677
      Location:16275
      F-BAR_FCHSD2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH and double SH3 domains 2 (FCHSD2)
      cd11761
      Location:471527
      SH3_FCHSD_1; First Src Homology 3 domain of FCH and double SH3 domains proteins
      cd11894
      Location:571626
      SH3_FCHSD2_2; Second Src Homology 3 domain of FCH and double SH3 domains protein 2
    2. NM_199012.2NP_950177.2  F-BAR and double SH3 domains protein 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK141949, BC060647
      Consensus CDS
      CCDS52327.1
      UniProtKB/Swiss-Prot
      Q3USJ8
      Related
      ENSMUSP00000032931.8, ENSMUST00000032931.9
      Conserved Domains (3) summary
      cd07677
      Location:16275
      F-BAR_FCHSD2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH and double SH3 domains 2 (FCHSD2)
      cd11761
      Location:495551
      SH3_FCHSD_1; First Src Homology 3 domain of FCH and double SH3 domains proteins
      cd11894
      Location:595650
      SH3_FCHSD2_2; Second Src Homology 3 domain of FCH and double SH3 domains protein 2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      100757836..100933613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507518.4XP_006507581.1  F-BAR and double SH3 domains protein 2 isoform X3

      Conserved Domains (3) summary
      cd11761
      Location:335391
      SH3_FCHSD_1; First Src Homology 3 domain of FCH and double SH3 domains proteins
      cd11894
      Location:435490
      SH3_FCHSD2_2; Second Src Homology 3 domain of FCH and double SH3 domains protein 2
      cl12013
      Location:1115
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. XM_036152850.1XP_036008743.1  F-BAR and double SH3 domains protein 2 isoform X4

      Conserved Domains (3) summary
      cd11761
      Location:311367
      SH3_FCHSD_1; First Src Homology 3 domain of FCH and double SH3 domains proteins
      cd11894
      Location:411466
      SH3_FCHSD2_2; Second Src Homology 3 domain of FCH and double SH3 domains protein 2
      cl12013
      Location:1115
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    3. XM_030242304.2XP_030098164.1  F-BAR and double SH3 domains protein 2 isoform X2

      Conserved Domains (3) summary
      cd11761
      Location:389445
      SH3_FCHSD_1; First Src Homology 3 domain of FCH and double SH3 domains proteins
      cd11894
      Location:489544
      SH3_FCHSD2_2; Second Src Homology 3 domain of FCH and double SH3 domains protein 2
      cl12013
      Location:1193
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    4. XM_006507517.4XP_006507580.1  F-BAR and double SH3 domains protein 2 isoform X1

      Conserved Domains (3) summary
      cd11761
      Location:413469
      SH3_FCHSD_1; First Src Homology 3 domain of FCH and double SH3 domains proteins
      cd11894
      Location:513568
      SH3_FCHSD2_2; Second Src Homology 3 domain of FCH and double SH3 domains protein 2
      cl12013
      Location:1193
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
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