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    Fchsd2 FCH and double SH3 domains 2 [ Mus musculus (house mouse) ]

    Gene ID: 207278, updated on 8-Oct-2018

    Summary

    Official Symbol
    Fchsd2provided by MGI
    Official Full Name
    FCH and double SH3 domains 2provided by MGI
    Primary source
    MGI:MGI:2448475
    See related
    Ensembl:ENSMUSG00000030691 Vega:OTTMUSG00000025163
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    R74866; Sh3md3; BC034086; mKIAA0769
    Expression
    Ubiquitous expression in CNS E18 (RPKM 15.4), whole brain E14.5 (RPKM 12.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Fchsd2 in Genome Data Viewer
    Location:
    7; 7 E2
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (101108711..101284405)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (108257289..108432919)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2Y, G-protein coupled 2 Neighboring gene ribosomal protein S29 pseudogene Neighboring gene ribosomal protein L27 pseudogene Neighboring gene uncharacterized LOC108167450 Neighboring gene autophagy related 16-like 2 (S. cerevisiae) Neighboring gene START domain containing 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    neuromuscular synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    neuromuscular junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    F-BAR and double SH3 domains protein 2
    Names
    FCH and double SH3 domains protein 2
    SH3 multiple domains 3
    SH3 multiple domains protein 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146010.1NP_001139482.1  F-BAR and double SH3 domains protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001139482.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the mid coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AK140322, AK141949, BC060647
      Consensus CDS
      CCDS52328.1
      UniProtKB/Swiss-Prot
      Q3USJ8
      Related
      ENSMUSP00000095850.3, OTTMUSP00000030461, ENSMUST00000098250.9, OTTMUST00000061907
      Conserved Domains (3) summary
      cd07677
      Location:16275
      F-BAR_FCHSD2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH and double SH3 domains 2 (FCHSD2)
      cd11761
      Location:471527
      SH3_FCHSD_1; First Src Homology 3 domain of FCH and double SH3 domains proteins
      cd11894
      Location:571626
      SH3_FCHSD2_2; Second Src Homology 3 domain of FCH and double SH3 domains protein 2
    2. NM_199012.2NP_950177.2  F-BAR and double SH3 domains protein 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK141949, BC060647
      Consensus CDS
      CCDS52327.1
      UniProtKB/Swiss-Prot
      Q3USJ8
      Related
      ENSMUSP00000032931.7, OTTMUSP00000030460, ENSMUST00000032931.8, OTTMUST00000061906
      Conserved Domains (3) summary
      cd07677
      Location:16275
      F-BAR_FCHSD2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH and double SH3 domains 2 (FCHSD2)
      cd11761
      Location:495551
      SH3_FCHSD_1; First Src Homology 3 domain of FCH and double SH3 domains proteins
      cd11894
      Location:595650
      SH3_FCHSD2_2; Second Src Homology 3 domain of FCH and double SH3 domains protein 2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      101108711..101284405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507518.2XP_006507581.1  F-BAR and double SH3 domains protein 2 isoform X2

      Conserved Domains (3) summary
      cd11761
      Location:335391
      SH3_FCHSD_1; First Src Homology 3 domain of FCH and double SH3 domains proteins
      cd11894
      Location:435490
      SH3_FCHSD2_2; Second Src Homology 3 domain of FCH and double SH3 domains protein 2
      cl12013
      Location:1115
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. XM_006507517.3XP_006507580.1  F-BAR and double SH3 domains protein 2 isoform X1

      Conserved Domains (3) summary
      cd11761
      Location:413469
      SH3_FCHSD_1; First Src Homology 3 domain of FCH and double SH3 domains proteins
      cd11894
      Location:513568
      SH3_FCHSD2_2; Second Src Homology 3 domain of FCH and double SH3 domains protein 2
      cl12013
      Location:1193
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
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