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    Larp4 La ribonucleoprotein domain family, member 4 [ Mus musculus (house mouse) ]

    Gene ID: 207214, updated on 5-Aug-2018

    Summary

    Official Symbol
    Larp4provided by MGI
    Official Full Name
    La ribonucleoprotein domain family, member 4provided by MGI
    Primary source
    MGI:MGI:2443114
    See related
    Ensembl:ENSMUSG00000023025
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DXErtd793; DXErtd793e
    Expression
    Ubiquitous expression in placenta adult (RPKM 11.6), CNS E11.5 (RPKM 5.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Larp4 in Genome Data Viewer
    Location:
    15; 15 F1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (99970065..100016358)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (99800505..99846789)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700121M21 gene Neighboring gene 40S ribosomal protein S10-like Neighboring gene family with sequence similarity 186, member A Neighboring gene RIKEN cDNA 2310068J16 gene Neighboring gene disco interacting protein 2 homolog B Neighboring gene activating transcription factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • C530046N12, D330037H05Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    poly(A) binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with cytosolic small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with polysome ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024526.2NP_001019697.2  la-related protein 4 isoform 1

      See identical proteins and their annotated locations for NP_001019697.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform (1).
      Source sequence(s)
      AC133868, AK049756, AK139909, BP757308, CJ080411
      Consensus CDS
      CCDS37208.1
      UniProtKB/Swiss-Prot
      Q8BWW4
      UniProtKB/TrEMBL
      G3X9Q6, Q3UT02
      Related
      ENSMUSP00000097780.2, ENSMUST00000100206.3
      Conserved Domains (2) summary
      cd08035
      Location:116190
      LARP_4; La RNA-binding domain of La-related protein 4
      cd12707
      Location:195271
      RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
    2. NM_001080948.2NP_001074417.1  la-related protein 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5'-terminal exon, initiates translation at an alternate start codon, and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AI853685, AK052358, AK139636, AK139909, AK141743, BE951991, CJ083603
      Consensus CDS
      CCDS49730.1
      UniProtKB/Swiss-Prot
      Q8BWW4
      UniProtKB/TrEMBL
      E9Q066, Q3UT02
      Related
      ENSMUSP00000086964.5, ENSMUST00000057632.15
      Conserved Domains (2) summary
      cd08035
      Location:115189
      LARP_4; La RNA-binding domain of La-related protein 4
      cd12707
      Location:194270
      RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
    3. NM_001284521.1NP_001271450.1  la-related protein 4 isoform 3

      See identical proteins and their annotated locations for NP_001271450.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AI853685, AK052358, AK139636, AK139909, AK141743, BE951991, CJ080411
      UniProtKB/Swiss-Prot
      Q8BWW4
      UniProtKB/TrEMBL
      Q3UT02
      Related
      ENSMUSP00000155661.1, ENSMUST00000231160.1
      Conserved Domains (2) summary
      cd08035
      Location:57131
      LARP_4; La RNA-binding domain of La-related protein 4
      cd12707
      Location:136212
      RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
    4. NM_001284522.1NP_001271451.1  la-related protein 4 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate 5'-terminal exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AI853685, AK052358, AK139636, AK139909, AK141743, BE951991, CJ083603
      UniProtKB/Swiss-Prot
      Q8BWW4
      UniProtKB/TrEMBL
      Q3UT02
      Conserved Domains (2) summary
      cd08035
      Location:114188
      LARP_4; La RNA-binding domain of La-related protein 4
      cd12707
      Location:193269
      RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
    5. NM_001284523.1NP_001271452.1  la-related protein 4 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (5) is longer, compared to isoform 1.
      Source sequence(s)
      AI853685, AK052358, AK139636, AK139909, AK141743, BE951991, CJ080411
      UniProtKB/Swiss-Prot
      Q8BWW4
      UniProtKB/TrEMBL
      Q3UT02
      Related
      ENSMUSP00000155601.1, ENSMUST00000230956.1
      Conserved Domains (2) summary
      cd08035
      Location:117191
      LARP_4; La RNA-binding domain of La-related protein 4
      cd12707
      Location:196272
      RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      99970065..100016358
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520675.1XP_006520738.1  la-related protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006520738.1

      Conserved Domains (2) summary
      cd08035
      Location:57131
      LARP_4; La RNA-binding domain of La-related protein 4
      cd12707
      Location:136212
      RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
    2. XM_017316524.1XP_017172013.1  la-related protein 4 isoform X1

      Conserved Domains (2) summary
      cd08035
      Location:57131
      LARP_4; La RNA-binding domain of La-related protein 4
      cd12707
      Location:136212
      RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
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