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    Son Son DNA binding protein [ Mus musculus (house mouse) ]

    Gene ID: 20658, updated on 23-Jun-2021

    Summary

    Official Symbol
    Sonprovided by MGI
    Official Full Name
    Son DNA binding proteinprovided by MGI
    Primary source
    MGI:MGI:98353
    See related
    Ensembl:ENSMUSG00000022961
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    nrebp; C81487; AA409051; AU067731; mKIAA1019; 2900011L12Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 48.2), ovary adult (RPKM 44.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Son in Genome Data Viewer
    Location:
    16 C3.3- C4; 16 53.22 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (91444712..91476080)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (91647824..91679192)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (91648069..91679437)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C28 Neighboring gene phosphoribosylglycinamide formyltransferase Neighboring gene predicted gene, 36712 Neighboring gene downstream neighbor of SON Neighboring gene predicted gene 10785 Neighboring gene crystallin, zeta (quinone reductase)-like 1 Neighboring gene predicted gene, 46543

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RS domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein SON
    Names
    NRE-binding protein
    Son cell proliferation protein
    negative regulatory element-binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019973.2NP_064357.2  protein SON isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple 3' coding exons and contains an alternate 3' exon, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC131691, AK040621, BC061113, BG229132, CJ088081
      Consensus CDS
      CCDS37400.1
      UniProtKB/TrEMBL
      Q8C9T5
      Related
      ENSMUSP00000109670.3, ENSMUST00000114036.9
      Conserved Domains (1) summary
      pfam08430
      Location:10111137
      Forkhead_N; Forkhead N-terminal region
    2. NM_178880.4NP_849211.3  protein SON isoform 1

      See identical proteins and their annotated locations for NP_849211.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC131691, AK040621, AK122418, BC061113, CB849818, CJ088081
      Consensus CDS
      CCDS37399.1
      UniProtKB/Swiss-Prot
      Q9QX47
      UniProtKB/TrEMBL
      Q80TM4, Q8C9T5
      Related
      ENSMUSP00000109671.3, ENSMUST00000114037.9
      Conserved Domains (3) summary
      cd00048
      Location:23892426
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam08430
      Location:10111137
      Forkhead_N; Forkhead N-terminal region
      pfam01585
      Location:23232366
      G-patch; G-patch domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      91444712..91476080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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