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    Snrpe small nuclear ribonucleoprotein E [ Mus musculus (house mouse) ]

    Gene ID: 20643, updated on 26-Sep-2022

    Summary

    Official Symbol
    Snrpeprovided by MGI
    Official Full Name
    small nuclear ribonucleoprotein Eprovided by MGI
    Primary source
    MGI:MGI:98346
    See related
    Ensembl:ENSMUSG00000090553 AllianceGenome:MGI:98346
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SME
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in hair cycle and spliceosomal snRNP assembly. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in cytosol and nucleus. Predicted to be part of several cellular components, including methylosome; small nuclear ribonucleoprotein complex; and spliceosomal complex. Is expressed in central nervous system; sensory organ; and tooth. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; hypotrichosis 1; hypotrichosis 11; and lupus nephritis. Orthologous to human SNRPE (small nuclear ribonucleoprotein polypeptide E). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 136.5), liver E14 (RPKM 135.9) and 19 other tissues See more
    Orthologs
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    Genomic context

    See Snrpe in Genome Data Viewer
    Location:
    1; 1 E4
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (133531609..133538018, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (133603871..133610280, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7A pseudogene Neighboring gene predicted gene, 23939 Neighboring gene predicted gene, 53475 Neighboring gene zinc finger CCCH type containing 11A Neighboring gene zinc finger, BED type containing 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables U1 snRNP binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spliceosomal snRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in spliceosomal snRNP assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of SMN-Sm protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of U1 snRNP ISO
    Inferred from Sequence Orthology
    more info
     
    part_of U12-type spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of U2-type catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of U4 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of U4 snRNP ISO
    Inferred from Sequence Orthology
    more info
     
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of U4/U6 x U5 tri-snRNP complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of U5 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of U7 snRNP ISO
    Inferred from Sequence Orthology
    more info
     
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of methylosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of pICln-Sm protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of precatalytic spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of telomerase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    small nuclear ribonucleoprotein E
    Names
    sm protein E
    sm-E
    snRNP-E

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009227.3NP_033253.1  small nuclear ribonucleoprotein E

      See identical proteins and their annotated locations for NP_033253.1

      Status: VALIDATED

      Source sequence(s)
      AW492281, BY168551
      Consensus CDS
      CCDS48364.1
      UniProtKB/Swiss-Prot
      P62305, Q15498
      UniProtKB/TrEMBL
      A0A6P5Q3Y1, A0A8C6HK12
      Related
      ENSMUSP00000128400.2, ENSMUST00000166915.8
      Conserved Domains (1) summary
      cd01718
      Location:1189
      Sm_E; Sm protein E

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      133531609..133538018 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)