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    ERBB2 erb-b2 receptor tyrosine kinase 2 [ Homo sapiens (human) ]

    Gene ID: 2064, updated on 5-Dec-2021

    Summary

    Official Symbol
    ERBB2provided by HGNC
    Official Full Name
    erb-b2 receptor tyrosine kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:3430
    See related
    Ensembl:ENSG00000141736 MIM:164870
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NEU; NGL; HER2; TKR1; CD340; HER-2; VSCN2; MLN 19; HER-2/neu
    Summary
    This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in kidney (RPKM 34.7), skin (RPKM 30.2) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ERBB2 in Genome Data Viewer
    Location:
    17q12
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (39688094..39728660)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (37844347..37884911)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs1769 Neighboring gene phenylethanolamine N-methyltransferase Neighboring gene post-GPI attachment to proteins phospholipase 3 Neighboring gene microRNA 4728 Neighboring gene migration and invasion enhancer 1 Neighboring gene growth factor receptor bound protein 7 Neighboring gene IKAROS family zinc finger 3 Neighboring gene keratin 8 pseudogene 34

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Cetuximab response
    MedGen: CN077967 GeneReviews: Not available
    Compare labs
    Glioma susceptibility 1
    MedGen: C2750850 OMIM: 137800 GeneReviews: Not available
    Compare labs
    Lung cancer
    MedGen: C0242379 OMIM: 211980 GeneReviews: Not available
    Compare labs
    Neoplasm of ovary
    MedGen: C0919267 OMIM: 167000 GeneReviews: Not available
    Compare labs
    Panitumumab response
    MedGen: CN077999 GeneReviews: Not available
    Compare labs
    Pertuzumab response
    MedGen: CN233145 GeneReviews: Not available
    not available
    Stomach cancer
    MedGen: C0024623 OMIM: 613659 GeneReviews: Not available
    Compare labs
    Trastuzumab response
    MedGen: CN078025 GeneReviews: Not available
    Compare labs
    VISCERAL NEUROPATHY, FAMILIAL, 2, AUTOSOMAL RECESSIVE
    MedGen: CN300314 OMIM: 619465 GeneReviews: Not available
    Compare labs

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ErbB-3 class receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA polymerase I core binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to growth factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine kinase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transmembrane signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell surface receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to epidermal growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in enzyme linked receptor protein signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in heart development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in motor neuron axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in myelination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of immature T cell proliferation in thymus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuromuscular junction development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in oligodendrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peripheral nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylinositol 3-kinase signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of epithelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein targeting to membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase I IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of angiogenesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of microtubule-based process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in transmembrane receptor protein tyrosine kinase signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in transmembrane receptor protein tyrosine kinase signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in wound healing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of ERBB3:ERBB2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in basal plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of receptor complex TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    receptor tyrosine-protein kinase erbB-2
    Names
    c-erb B2/neu protein
    herstatin
    human epidermal growth factor receptor 2
    metastatic lymph node gene 19 protein
    neuro/glioblastoma derived oncogene homolog
    neuroblastoma/glioblastoma derived oncogene homolog
    proto-oncogene Neu
    proto-oncogene c-ErbB-2
    tyrosine kinase-type cell surface receptor HER2
    v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
    v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2
    v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
    NP_001005862.1
    NP_001276865.1
    NP_001276866.1
    NP_001276867.1
    NP_001369711.1
    NP_001369712.1
    NP_001369713.1
    NP_001369714.1
    NP_001369715.1
    NP_001369716.1
    NP_001369717.1
    NP_001369718.1
    NP_001369719.1
    NP_001369720.1
    NP_001369721.1
    NP_001369722.1
    NP_001369723.1
    NP_001369724.1
    NP_001369725.1
    NP_001369726.1
    NP_001369727.1
    NP_001369728.1
    NP_001369729.1
    NP_001369730.1
    NP_001369731.1
    NP_001369732.1
    NP_001369733.1
    NP_001369734.1
    NP_001369735.1
    NP_004439.2
    XP_024306409.1
    XP_024306410.1
    XP_024306411.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007503.1 RefSeqGene

      Range
      4945..45523
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_724

    mRNA and Protein(s)

    1. NM_001005862.3NP_001005862.1  receptor tyrosine-protein kinase erbB-2 isoform b

      See identical proteins and their annotated locations for NP_001005862.1

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Consensus CDS
      CCDS45667.1
      UniProtKB/Swiss-Prot
      P04626
      Related
      ENSP00000462438.1, ENST00000584601.5
      Conserved Domains (5) summary
      cd12094
      Location:611654
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:682960
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:159308
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:22143
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:481613
      GF_recep_IV; Growth factor receptor domain IV
    2. NM_001289936.2NP_001276865.1  receptor tyrosine-protein kinase erbB-2 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Consensus CDS
      CCDS74052.1
      UniProtKB/Swiss-Prot
      P04626
      Related
      ENSP00000446466.1, ENST00000541774.5
      Conserved Domains (8) summary
      cd12094
      Location:626669
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      smart00261
      Location:542588
      FU; Furin-like repeats
      cd00064
      Location:220265
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      cd05109
      Location:697975
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:174323
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:37158
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:705961
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14843
      Location:496628
      GF_recep_IV; Growth factor receptor domain IV
    3. NM_001289937.2NP_001276866.1  receptor tyrosine-protein kinase erbB-2 isoform d precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Consensus CDS
      CCDS77016.1
      UniProtKB/TrEMBL
      J3QLU9
      Related
      ENSP00000463714.1, ENST00000584450.5
      Conserved Domains (8) summary
      cd12094
      Location:641684
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      smart00261
      Location:557603
      FU; Furin-like repeats
      cd00064
      Location:235280
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      cd05109
      Location:712990
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:189338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52173
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:720976
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14843
      Location:511643
      GF_recep_IV; Growth factor receptor domain IV
    4. NM_001289938.2NP_001276867.1  receptor tyrosine-protein kinase erbB-2 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC087491
      Consensus CDS
      CCDS77017.1
      UniProtKB/Swiss-Prot
      P04626
      UniProtKB/TrEMBL
      F5H1T4
      Related
      ENSP00000462808.1, ENST00000578199.5
      Conserved Domains (5) summary
      smart00261
      Location:527573
      FU; Furin-like repeats
      cd00064
      Location:205250
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00757
      Location:159308
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:22143
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:481603
      GF_recep_IV; Growth factor receptor domain IV
    5. NM_001382782.1NP_001369711.1  receptor tyrosine-protein kinase erbB-2 isoform b

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (5) summary
      cd12094
      Location:611654
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:682960
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:159308
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:22143
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:481613
      GF_recep_IV; Growth factor receptor domain IV
    6. NM_001382783.1NP_001369712.1  receptor tyrosine-protein kinase erbB-2 isoform b

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (5) summary
      cd12094
      Location:611654
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:682960
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:159308
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:22143
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:481613
      GF_recep_IV; Growth factor receptor domain IV
    7. NM_001382784.1NP_001369713.1  receptor tyrosine-protein kinase erbB-2 isoform f precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (5) summary
      cd12094
      Location:680723
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:7511029
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:189338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:550682
      GF_recep_IV; Growth factor receptor domain IV
    8. NM_001382785.1NP_001369714.1  receptor tyrosine-protein kinase erbB-2 isoform g precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (5) summary
      cd12094
      Location:675718
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:7461024
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:189338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:511677
      GF_recep_IV; Growth factor receptor domain IV
    9. NM_001382786.1NP_001369715.1  receptor tyrosine-protein kinase erbB-2 isoform h precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (6) summary
      cd12094
      Location:680723
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      COG3170
      Location:10901219
      FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
      pfam00757
      Location:189338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:550682
      GF_recep_IV; Growth factor receptor domain IV
      cl21453
      Location:7511017
      PKc_like; Protein Kinases, catalytic domain
    10. NM_001382787.1NP_001369716.1  receptor tyrosine-protein kinase erbB-2 isoform i precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (5) summary
      cd12094
      Location:666709
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:7371015
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:214363
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52198
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:536668
      GF_recep_IV; Growth factor receptor domain IV
    11. NM_001382788.1NP_001369717.1  receptor tyrosine-protein kinase erbB-2 isoform j precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (5) summary
      cd12094
      Location:651694
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:7221000
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:189338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:521653
      GF_recep_IV; Growth factor receptor domain IV
    12. NM_001382789.1NP_001369718.1  receptor tyrosine-protein kinase erbB-2 isoform k precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (5) summary
      cd12094
      Location:648691
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:719997
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:189338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:518650
      GF_recep_IV; Growth factor receptor domain IV
    13. NM_001382790.1NP_001369719.1  receptor tyrosine-protein kinase erbB-2 isoform l precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (5) summary
      cd12094
      Location:640683
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:711989
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:189338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:511642
      GF_recep_IV; Growth factor receptor domain IV
    14. NM_001382791.1NP_001369720.1  receptor tyrosine-protein kinase erbB-2 isoform m precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (5) summary
      cd12094
      Location:638681
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:709987
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:186335
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52170
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:508640
      GF_recep_IV; Growth factor receptor domain IV
    15. NM_001382792.1NP_001369721.1  receptor tyrosine-protein kinase erbB-2 isoform n precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (6) summary
      cd12094
      Location:641684
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      COG3170
      Location:10511180
      FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
      pfam00757
      Location:189338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:511643
      GF_recep_IV; Growth factor receptor domain IV
      cl21453
      Location:712978
      PKc_like; Protein Kinases, catalytic domain
    16. NM_001382793.1NP_001369722.1  receptor tyrosine-protein kinase erbB-2 isoform o precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (6) summary
      cd12094
      Location:641684
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      COG3170
      Location:10491178
      FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
      pfam00757
      Location:189338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:511643
      GF_recep_IV; Growth factor receptor domain IV
      cl21453
      Location:712976
      PKc_like; Protein Kinases, catalytic domain
    17. NM_001382794.1NP_001369723.1  receptor tyrosine-protein kinase erbB-2 isoform p precorsor precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (5) summary
      cd12094
      Location:641684
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:698976
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:189338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:511643
      GF_recep_IV; Growth factor receptor domain IV
    18. NM_001382795.1NP_001369724.1  receptor tyrosine-protein kinase erbB-2 isoform q precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (4) summary
      cd05109
      Location:696974
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:189338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:511633
      GF_recep_IV; Growth factor receptor domain IV
    19. NM_001382796.1NP_001369725.1  receptor tyrosine-protein kinase erbB-2 isoform r precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (5) summary
      cd12094
      Location:641684
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:712990
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:189338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:511643
      GF_recep_IV; Growth factor receptor domain IV
    20. NM_001382797.1NP_001369726.1  receptor tyrosine-protein kinase erbB-2 isoform s precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (6) summary
      cd12094
      Location:641684
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      COG3170
      Location:10301159
      FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
      pfam00757
      Location:189338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:511643
      GF_recep_IV; Growth factor receptor domain IV
      cl21453
      Location:712957
      PKc_like; Protein Kinases, catalytic domain
    21. NM_001382798.1NP_001369727.1  receptor tyrosine-protein kinase erbB-2 isoform t precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (6) summary
      cd12094
      Location:641684
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      COG3170
      Location:10111140
      FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
      pfam00757
      Location:189338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:511643
      GF_recep_IV; Growth factor receptor domain IV
      cl21453
      Location:712938
      PKc_like; Protein Kinases, catalytic domain
    22. NM_001382799.1NP_001369728.1  receptor tyrosine-protein kinase erbB-2 isoform u precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (5) summary
      cd12094
      Location:581624
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:652930
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:148278
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52147
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:451583
      GF_recep_IV; Growth factor receptor domain IV
    23. NM_001382800.1NP_001369729.1  receptor tyrosine-protein kinase erbB-2 isoform v precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (6) summary
      cd12094
      Location:641684
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      COG3170
      Location:10011130
      FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
      pfam00757
      Location:189338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:511643
      GF_recep_IV; Growth factor receptor domain IV
      cl21453
      Location:712928
      PKc_like; Protein Kinases, catalytic domain
    24. NM_001382801.1NP_001369730.1  receptor tyrosine-protein kinase erbB-2 isoform w precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (5) summary
      COG3170
      Location:9951124
      FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
      pfam00757
      Location:189338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:511633
      GF_recep_IV; Growth factor receptor domain IV
      cl21453
      Location:696922
      PKc_like; Protein Kinases, catalytic domain
    25. NM_001382802.1NP_001369731.1  receptor tyrosine-protein kinase erbB-2 isoform x precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (5) summary
      cd12094
      Location:555598
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:626904
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:201252
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:425557
      GF_recep_IV; Growth factor receptor domain IV
    26. NM_001382803.1NP_001369732.1  receptor tyrosine-protein kinase erbB-2 isoform y precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (5) summary
      cd12094
      Location:641684
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      pfam00757
      Location:189338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:511643
      GF_recep_IV; Growth factor receptor domain IV
      cl21453
      Location:712976
      PKc_like; Protein Kinases, catalytic domain
    27. NM_001382804.1NP_001369733.1  receptor tyrosine-protein kinase erbB-2 isoform z precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Related
      ENSP00000404047.2, ENST00000445658.6
      Conserved Domains (5) summary
      cd12094
      Location:365408
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:436714
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:2562
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:90206
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:235367
      GF_recep_IV; Growth factor receptor domain IV
    28. NM_001382805.1NP_001369734.1  receptor tyrosine-protein kinase erbB-2 isoform aa precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (6) summary
      cd12094
      Location:641684
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      COG3170
      Location:746875
      FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
      pfam00757
      Location:189338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:511643
      GF_recep_IV; Growth factor receptor domain IV
      cl21453
      Location:712736
      PKc_like; Protein Kinases, catalytic domain
    29. NM_001382806.1NP_001369735.1  receptor tyrosine-protein kinase erbB-2 isoform bb precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (4) summary
      COG3170
      Location:717846
      FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
      pfam00757
      Location:189338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52173
      Recep_L_domain; Receptor L domain
      cl21453
      Location:406644
      PKc_like; Protein Kinases, catalytic domain
    30. NM_004448.4NP_004439.2  receptor tyrosine-protein kinase erbB-2 isoform a precursor

      See identical proteins and their annotated locations for NP_004439.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC079199, AC087491, BC167147
      Consensus CDS
      CCDS32642.1
      UniProtKB/Swiss-Prot
      P04626
      UniProtKB/TrEMBL
      X5DNK3
      Related
      ENSP00000269571.4, ENST00000269571.10
      Conserved Domains (8) summary
      cd12094
      Location:641684
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      smart00261
      Location:557603
      FU; Furin-like repeats
      cd00064
      Location:235280
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      cd05109
      Location:712990
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:189338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52173
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:720976
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14843
      Location:511643
      GF_recep_IV; Growth factor receptor domain IV

    RNA

    1. NR_110535.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Related
      ENST00000578373.5

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      39688094..39728660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024450643.1XP_024306411.1  receptor tyrosine-protein kinase erbB-2 isoform X3

      Conserved Domains (5) summary
      cd12094
      Location:657700
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:7281006
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:159354
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:22143
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:527659
      GF_recep_IV; Growth factor receptor domain IV
    2. XM_024450642.1XP_024306410.1  receptor tyrosine-protein kinase erbB-2 isoform X2

      Conserved Domains (5) summary
      cd12094
      Location:672715
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:7431021
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:174369
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:37158
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:542674
      GF_recep_IV; Growth factor receptor domain IV
    3. XM_024450641.1XP_024306409.1  receptor tyrosine-protein kinase erbB-2 isoform X1

      Conserved Domains (5) summary
      cd12094
      Location:687730
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:7581036
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:189384
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:557689
      GF_recep_IV; Growth factor receptor domain IV
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