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    Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 [ Mus musculus (house mouse) ]

    Gene ID: 20586, updated on 26-Sep-2022

    Summary

    Official Symbol
    Smarca4provided by MGI
    Official Full Name
    SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4provided by MGI
    Primary source
    MGI:MGI:88192
    See related
    Ensembl:ENSMUSG00000032187 AllianceGenome:MGI:88192
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Brg1; BAF190A; SW1/SNF; HP1-BP72; SNF2beta; b2b692Clo; b2b508.1Clo
    Summary
    Enables several functions, including ATP hydrolysis activity; DNA polymerase binding activity; and nucleic acid binding activity. Involved in nervous system development; positive regulation of Wnt signaling pathway; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within with a negative effect on gene expression. Acts upstream of or within several processes, including animal organ development; blastocyst development; and circulatory system development. Located in euchromatin; heterochromatin; and perichromatin fibrils. Part of SWI/SNF complex; nBAF complex; and npBAF complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Used to study breast cancer. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 4; hepatocellular carcinoma; lung non-small cell carcinoma; and rhabdoid cancer. Orthologous to human SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 48.7), CNS E14 (RPKM 45.5) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Smarca4 in Genome Data Viewer
    Location:
    9 A3; 9 7.84 cM
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21527377..21615526)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21616106..21704230)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7904 Neighboring gene microRNA 1946b Neighboring gene predicted gene, 26511 Neighboring gene low density lipoprotein receptor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ATP hydrolysis activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables ATP-dependent activity, acting on DNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ATP-dependent activity, acting on DNA ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables DNA polymerase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables DNA polymerase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to RNA polymerase I core promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables Tat protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lncRNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables lysine-acetylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear androgen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coregulator binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA methylation on cytosine within a CG sequence IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within DNA methylation-dependent heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within aorta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within aortic smooth muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within blastocyst growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within blastocyst hatching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IC
    Inferred by Curator
    more info
    PubMed 
    acts_upstream_of_or_within chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within coronary vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within definitive erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic hindlimb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within epidermis morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within_negative_effect gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within glial cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within heart trabecula formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within hindbrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within histone H3 acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within keratinocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lens fiber cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within liver development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell differentiation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neurogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within nucleosome assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in nucleosome disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within outflow tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within pharyngeal arch artery morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation by host of viral transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of DNA binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T cell differentiation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in positive regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell differentiation IC
    Inferred by Curator
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IC
    Inferred by Curator
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of double-strand break repair IC
    Inferred by Curator
    more info
    PubMed 
    involved_in positive regulation of glucose mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of miRNA transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of myoblast differentiation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in positive regulation of stem cell population maintenance IC
    Inferred by Curator
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within primitive erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of G0 to G1 transition IC
    Inferred by Curator
    more info
    PubMed 
    involved_in regulation of G1/S transition of mitotic cell cycle IC
    Inferred by Curator
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mitotic metaphase/anaphase transition IC
    Inferred by Curator
    more info
    PubMed 
    involved_in regulation of nucleotide-excision repair IC
    Inferred by Curator
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IC
    Inferred by Curator
    more info
    PubMed 
    acts_upstream_of_or_within stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ventricular septum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of GBAF complex IC
    Inferred by Curator
    more info
    PubMed 
    part_of RSC-type complex IC
    Inferred by Curator
    more info
    PubMed 
    part_of SWI/SNF complex IC
    Inferred by Curator
    more info
    PubMed 
    part_of SWI/SNF complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SWI/SNF complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of SWI/SNF complex TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of SWI/SNF superfamily-type complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of bBAF complex IC
    Inferred by Curator
    more info
    PubMed 
    located_in chromatin IC
    Inferred by Curator
    more info
    PubMed 
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in euchromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in kinetochore IC
    Inferred by Curator
    more info
    PubMed 
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of nBAF complex IC
    Inferred by Curator
    more info
    PubMed 
    part_of nBAF complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of npBAF complex IC
    Inferred by Curator
    more info
    PubMed 
    part_of npBAF complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of npBAF complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear matrix IC
    Inferred by Curator
    more info
    PubMed 
    NOT located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perichromatin fibrils IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription activator BRG1
    Names
    ATP-dependent helicase SMARCA4
    BRG1-associated factor 190A
    SNF2-beta
    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
    protein brahma homolog 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001174078.1NP_001167549.1  transcription activator BRG1 isoform 1

      See identical proteins and their annotated locations for NP_001167549.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon and uses an alternate in-frame splice junction compared to variant 4. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 4.
      Source sequence(s)
      AK160825, BC079560
      Consensus CDS
      CCDS52737.1
      UniProtKB/Swiss-Prot
      Q3TKT4
      UniProtKB/TrEMBL
      A0A0R4J170, A0A6P5Q5T1
      Related
      ENSMUSP00000096547.4, ENSMUST00000098948.10
      Conserved Domains (9) summary
      cd05516
      Location:14281534
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:612656
      BRK; domain in transcription and CHROMO domain helicases
      PLN03142
      Location:7501232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370570
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42217
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07529
      Location:461531
      HSA
      pfam08880
      Location:171205
      QLQ
      pfam14619
      Location:12911356
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
    2. NM_001174079.1NP_001167550.1  transcription activator BRG1 isoform 3

      See identical proteins and their annotated locations for NP_001167550.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice junction compared to variant 4. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 4.
      Source sequence(s)
      AK160825, AK166837, BC079560
      Consensus CDS
      CCDS57662.1
      UniProtKB/Swiss-Prot
      Q3TKT4, Q6AXG8
      UniProtKB/TrEMBL
      A0A6P5QC95
      Related
      ENSMUSP00000133922.2, ENSMUST00000174008.8
      Conserved Domains (9) summary
      cd05516
      Location:14251530
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:612656
      BRK; domain in transcription and CHROMO domain helicases
      PLN03142
      Location:7501232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370570
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42217
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07529
      Location:461531
      HSA
      pfam08880
      Location:171205
      QLQ
      pfam14619
      Location:12911356
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
    3. NM_001357764.1NP_001344693.1  transcription activator BRG1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).
      Source sequence(s)
      AC161371
      UniProtKB/TrEMBL
      A0A6P5QDZ4
      Conserved Domains (9) summary
      cd05516
      Location:14581564
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:612656
      BRK; domain in transcription and CHROMO domain helicases
      PLN03142
      Location:7501232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370570
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42217
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07529
      Location:461531
      HSA
      pfam08880
      Location:171205
      QLQ
      pfam14619
      Location:13241389
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
    4. NM_011417.3NP_035547.2  transcription activator BRG1 isoform 2

      See identical proteins and their annotated locations for NP_035547.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 4. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 4..
      Source sequence(s)
      AK160825, BC079560
      Consensus CDS
      CCDS22909.1
      UniProtKB/Swiss-Prot
      Q3TKT4
      UniProtKB/TrEMBL
      A0A6P5QIE8
      Related
      ENSMUSP00000034707.9, ENSMUST00000034707.15
      Conserved Domains (9) summary
      cd05516
      Location:14251531
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:612656
      BRK; domain in transcription and CHROMO domain helicases
      PLN03142
      Location:7501232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370570
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42217
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07529
      Location:461531
      HSA
      pfam08880
      Location:171205
      QLQ
      pfam14619
      Location:12911356
      SnAC; Snf2-ATP coupling, chromatin remodelling complex

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      21527377..21615526
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242438.3XP_011240740.1  transcription activator BRG1 isoform X1

      See identical proteins and their annotated locations for XP_011240740.1

      UniProtKB/TrEMBL
      A0A6P7R8Y5
      Conserved Domains (9) summary
      cd05516
      Location:14611567
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:612656
      BRK; domain in transcription and CHROMO domain helicases
      PLN03142
      Location:7501232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370570
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42217
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07529
      Location:461531
      HSA
      pfam08880
      Location:171205
      QLQ
      pfam14619
      Location:13241389
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
    2. XM_011242434.1XP_011240736.1  transcription activator BRG1 isoform X1

      See identical proteins and their annotated locations for XP_011240736.1

      UniProtKB/TrEMBL
      A0A6P7R8Y5
      Conserved Domains (9) summary
      cd05516
      Location:14611567
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:612656
      BRK; domain in transcription and CHROMO domain helicases
      PLN03142
      Location:7501232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370570
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42217
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07529
      Location:461531
      HSA
      pfam08880
      Location:171205
      QLQ
      pfam14619
      Location:13241389
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
    3. XM_011242435.1XP_011240737.1  transcription activator BRG1 isoform X2

      UniProtKB/TrEMBL
      A0A6P7R7G1
      Conserved Domains (9) summary
      cd05516
      Location:14611566
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:612656
      BRK; domain in transcription and CHROMO domain helicases
      PLN03142
      Location:7501232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370570
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42217
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07529
      Location:461531
      HSA
      pfam08880
      Location:171205
      QLQ
      pfam14619
      Location:13241389
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
    4. XM_006510122.2XP_006510185.2  transcription activator BRG1 isoform X3

      See identical proteins and their annotated locations for XP_006510185.2

      UniProtKB/TrEMBL
      A0A6P5QDZ4
      Conserved Domains (9) summary
      cd05516
      Location:14581564
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:612656
      BRK; domain in transcription and CHROMO domain helicases
      PLN03142
      Location:7501232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370570
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42217
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07529
      Location:461531
      HSA
      pfam08880
      Location:171205
      QLQ
      pfam14619
      Location:13241389
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
    5. XM_011242436.1XP_011240738.1  transcription activator BRG1 isoform X4

      Conserved Domains (9) summary
      cd05516
      Location:14581563
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:612656
      BRK; domain in transcription and CHROMO domain helicases
      PLN03142
      Location:7501232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370570
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42217
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07529
      Location:461531
      HSA
      pfam08880
      Location:171205
      QLQ
      pfam14619
      Location:13241389
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
    6. XM_006510117.2XP_006510180.2  transcription activator BRG1 isoform X6

      See identical proteins and their annotated locations for XP_006510180.2

      UniProtKB/Swiss-Prot
      Q3TKT4
      UniProtKB/TrEMBL
      A0A0R4J170, A0A6P5Q5T1
      Conserved Domains (9) summary
      cd05516
      Location:14281534
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:612656
      BRK; domain in transcription and CHROMO domain helicases
      PLN03142
      Location:7501232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370570
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42217
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07529
      Location:461531
      HSA
      pfam08880
      Location:171205
      QLQ
      pfam14619
      Location:12911356
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
    7. XM_006510119.2XP_006510182.2  transcription activator BRG1 isoform X7

      See identical proteins and their annotated locations for XP_006510182.2

      UniProtKB/Swiss-Prot
      Q3TKT4
      UniProtKB/TrEMBL
      A0A6P5QIE8
      Conserved Domains (9) summary
      cd05516
      Location:14251531
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:612656
      BRK; domain in transcription and CHROMO domain helicases
      PLN03142
      Location:7501232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370570
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42217
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07529
      Location:461531
      HSA
      pfam08880
      Location:171205
      QLQ
      pfam14619
      Location:12911356
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
    8. XM_006510120.2XP_006510183.2  transcription activator BRG1 isoform X8

      See identical proteins and their annotated locations for XP_006510183.2

      UniProtKB/Swiss-Prot
      Q3TKT4, Q6AXG8
      UniProtKB/TrEMBL
      A0A6P5QC95
      Conserved Domains (9) summary
      cd05516
      Location:14251530
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:612656
      BRK; domain in transcription and CHROMO domain helicases
      PLN03142
      Location:7501232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370570
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42217
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07529
      Location:461531
      HSA
      pfam08880
      Location:171205
      QLQ
      pfam14619
      Location:12911356
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
    9. XM_011242437.4XP_011240739.1  transcription activator BRG1 isoform X5

      Conserved Domains (9) summary
      cd05516
      Location:14811587
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:632676
      BRK; domain in transcription and CHROMO domain helicases
      PLN03142
      Location:7701252
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:390590
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:62237
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:7511001
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07529
      Location:481551
      HSA
      pfam08880
      Location:191225
      QLQ
      pfam14619
      Location:13441409
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
    10. XM_030244151.1XP_030100011.1  transcription activator BRG1 isoform X9

      Conserved Domains (4) summary
      cd05516
      Location:713819
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      PLN03142
      Location:2484
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      cd17996
      Location:3233
      DEXHc_SMARCA2_SMARCA4; DEXH-box helicase domain of SMARCA2 and SMARCA4
      pfam14619
      Location:576641
      SnAC; Snf2-ATP coupling, chromatin remodelling complex