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    Slc9a1 solute carrier family 9 (sodium/hydrogen exchanger), member 1 [ Mus musculus (house mouse) ]

    Gene ID: 20544, updated on 26-Jul-2021

    Summary

    Official Symbol
    Slc9a1provided by MGI
    Official Full Name
    solute carrier family 9 (sodium/hydrogen exchanger), member 1provided by MGI
    Primary source
    MGI:MGI:102462
    See related
    Ensembl:ENSMUSG00000028854
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A; Nhe; ant; swe; Apnh; Nhe-; Nhe1; Mir5122; AW554487; mir-5122
    Expression
    Ubiquitous expression in stomach adult (RPKM 66.6), adrenal adult (RPKM 34.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Slc9a1 in Genome Data Viewer
    Location:
    4 D2.3; 4 66.25 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (133097022..133151013)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (133369711..133423702)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (132925687..132979613)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 222 Neighboring gene WD and tetratricopeptide repeats 1 Neighboring gene microRNA 5122 Neighboring gene RIKEN cDNA 1700091J24 gene Neighboring gene predicted gene, 42322

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables potassium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein phosphatase 2B binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sodium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables sodium:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sodium:proton antiporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables sodium:proton antiporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables solute:proton antiporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cardiac muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cation transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to acidic pH ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to epinephrine stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular sodium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryo development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcium:sodium antiporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cardiac muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial membrane permeability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of the force of heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in proton transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cardiac muscle contraction by calcium ion signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of intracellular pH ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of pH IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of pH IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of pH ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of the force of heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of the force of heart contraction by cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to acidic pH IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to acidic pH ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to muscle stretch ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in sodium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sodium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in T-tubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of cation-transporting ATPase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intercalated disc ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    sodium/hydrogen exchanger 1
    Names
    NHE-1
    Na(+)/H(+) exchanger 1
    Na+/H+ antiporter
    Na+/H+, amiloride sensitive
    slow-wave epilepsy
    solute carrier family 9, member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358455.1NP_001345384.1  sodium/hydrogen exchanger 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK150135, AK165501, AL671882, BQ771297, BU056477, CO041694
      Conserved Domains (1) summary
      TIGR00840
      Location:1321
      b_cpa1; sodium/hydrogen exchanger 3
    2. NM_016981.3NP_058677.1  sodium/hydrogen exchanger 1 isoform 1

      See identical proteins and their annotated locations for NP_058677.1

      Status: VALIDATED

      Source sequence(s)
      AK150135, AK165501, AL671882, BU056477, CO041694
      Consensus CDS
      CCDS38903.1
      UniProtKB/Swiss-Prot
      Q61165
      UniProtKB/TrEMBL
      Q3TN68, Q3UDC9
      Related
      ENSMUSP00000030669.8, ENSMUST00000030669.8
      Conserved Domains (3) summary
      TIGR00840
      Location:99664
      b_cpa1; sodium/hydrogen exchanger 3
      pfam00999
      Location:109507
      Na_H_Exchanger; Sodium/hydrogen exchanger family
      pfam16644
      Location:606704
      NEXCaM_BD; Regulatory region of Na+/H+ exchanger NHE binds to calmodulin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      133097022..133151013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320089.2XP_017175578.1  sodium/hydrogen exchanger 1 isoform X2

      Conserved Domains (1) summary
      TIGR00840
      Location:1321
      b_cpa1; sodium/hydrogen exchanger 3
    2. XM_006538686.4XP_006538749.1  sodium/hydrogen exchanger 1 isoform X1

      Conserved Domains (1) summary
      TIGR00840
      Location:25566
      b_cpa1; sodium/hydrogen exchanger 3
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