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    Slc1a1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 [ Mus musculus (house mouse) ]

    Gene ID: 20510, updated on 2-Oct-2018

    Summary

    Official Symbol
    Slc1a1provided by MGI
    Official Full Name
    solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1provided by MGI
    Primary source
    MGI:MGI:105083
    See related
    Ensembl:ENSMUSG00000024935 Vega:OTTMUSG00000033893
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EAAC1; EAAC2; EAAT3; MEAAC1; D130048G10Rik
    Expression
    Biased expression in genital fat pad adult (RPKM 43.4), kidney adult (RPKM 33.9) and 13 other tissues See more
    Orthologs

    Genomic context

    See Slc1a1 in Genome Data Viewer
    Location:
    19; 19 C1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (28835166..28913960)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (28909656..28988450)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein S15A, pseudogene 2 Neighboring gene predicted gene, 35922 Neighboring gene dynein family member Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene RIKEN cDNA 4430402I18 gene Neighboring gene phospholipid phosphatase 6 Neighboring gene phytanoyl-CoA hydroxylase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    L-glutamate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    L-glutamate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    chloride transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    cysteine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    glutamate binding ISO
    Inferred from Sequence Orthology
    more info
     
    glutamate:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamate:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    high-affinity glutamate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    D-aspartate import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    L-aspartate import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    L-glutamate import ISO
    Inferred from Sequence Orthology
    more info
     
    L-glutamate import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    L-glutamate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    L-glutamate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    amino acid transport IEA
    Inferred from Electronic Annotation
    more info
     
    chloride transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    cysteine transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of heart rate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein homooligomerization IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    excitatory amino acid transporter 3
    Names
    excitatory amino acid carrier 2
    excitatory amino-acid carrier 1
    glutamate transporter mEAAC2
    sodium-dependent glutamate/aspartate transporter 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009199.3NP_033225.1  excitatory amino acid transporter 3

      See identical proteins and their annotated locations for NP_033225.1

      Status: VALIDATED

      Source sequence(s)
      AC113961, AC163993
      Consensus CDS
      CCDS29727.1
      UniProtKB/Swiss-Prot
      P51906
      Related
      ENSMUSP00000025875.4, OTTMUSP00000046182, ENSMUST00000025875.4
      Conserved Domains (1) summary
      pfam00375
      Location:51464
      SDF; Sodium:dicarboxylate symporter family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      28835166..28913960
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 UNKNOWN

    Genomic

    1. NT_187018.1 Reference GRCm38.p4 UNKNOWN

      Range
      252..21645
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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