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    Sin3b transcriptional regulator, SIN3B (yeast) [ Mus musculus (house mouse) ]

    Gene ID: 20467, updated on 23-Jun-2021

    Summary

    Official Symbol
    Sin3bprovided by MGI
    Official Full Name
    transcriptional regulator, SIN3B (yeast)provided by MGI
    Primary source
    MGI:MGI:107158
    See related
    Ensembl:ENSMUSG00000031622
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810430C10Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 76.5), genital fat pad adult (RPKM 49.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Sin3b in Genome Data Viewer
    Location:
    8 B3.3; 8 35.08 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (73449898..73484831)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (72723270..72758203)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (75247187..75282102)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51538 Neighboring gene NACHT and WD repeat domain containing 1 Neighboring gene coagulation factor II (thrombin) receptor-like 3 Neighboring gene predicted gene, 39198

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Sin3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in X chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in XY body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Y chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in autosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of histone deacetylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    paired amphipathic helix protein Sin3b
    Names
    SIN3 homolog B, transcription regulator
    histone deacetylase complex subunit Sin3b
    transcriptional corepressor Sin3b
    transcriptional regulator, SIN3 yeast homolog B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113248.2NP_001106719.1  paired amphipathic helix protein Sin3b isoform 2

      See identical proteins and their annotated locations for NP_001106719.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC171917, AK169433, BF318403
      Consensus CDS
      CCDS52598.1
      UniProtKB/Swiss-Prot
      Q62141
      UniProtKB/TrEMBL
      Q3TN09
      Related
      ENSMUSP00000105576.4, ENSMUST00000109950.5
      Conserved Domains (1) summary
      pfam02671
      Location:5397
      PAH; Paired amphipathic helix repeat
    2. NM_009188.4NP_033214.2  paired amphipathic helix protein Sin3b isoform 1

      See identical proteins and their annotated locations for NP_033214.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer variant and encodes the longer isoform (1).
      Source sequence(s)
      AC171917, AK169433
      Consensus CDS
      CCDS52599.1
      UniProtKB/Swiss-Prot
      Q62141
      UniProtKB/TrEMBL
      Q3TN09
      Related
      ENSMUSP00000004494.9, ENSMUST00000004494.16
      Conserved Domains (3) summary
      pfam02671
      Location:5397
      PAH; Paired amphipathic helix repeat
      pfam08295
      Location:386480
      Sin3_corepress; Sin3 family co-repressor
      pfam16879
      Location:7121011
      Sin3a_C; C-terminal domain of Sin3a protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      73449898..73484831
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530789.2XP_006530852.1  paired amphipathic helix protein Sin3b isoform X1

      Conserved Domains (1) summary
      COG5602
      Location:401030
      Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
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