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    Tra2b transformer 2 beta [ Mus musculus (house mouse) ]

    Gene ID: 20462, updated on 12-Aug-2018

    Summary

    Official Symbol
    Tra2bprovided by MGI
    Official Full Name
    transformer 2 betaprovided by MGI
    Primary source
    MGI:MGI:106016
    See related
    Ensembl:ENSMUSG00000022858 Vega:OTTMUSG00000035118
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SIG-41; Sfrs10; Silg41; TRA2beta; D16Ertd266e; 5730405G21Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 57.4), CNS E14 (RPKM 44.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Tra2b in Genome Data Viewer
    Location:
    16 B1; 16 13.18 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (22245741..22266000, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (22245814..22266002, complement)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene transmembrane protein 97 pseudogene Neighboring gene predicted gene, 36796 Neighboring gene G protein subunit gamma 5, pseudogene Neighboring gene ets variant 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC102169

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    poly-purine tract binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pre-mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pre-mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cerebral cortex regionalization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex oligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    colocalizes_with nuclear inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transformer-2 protein homolog beta
    Names
    silica-induced gene 41 protein
    splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)
    transformer 2 beta homolog
    transformer-2 protein homolog B

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330554.1NP_001317483.1  transformer-2 protein homolog beta isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AC154605, AI847347, AK049573, CT009567, DV647445
      UniProtKB/Swiss-Prot
      P62996
      Conserved Domains (1) summary
      cl17169
      Location:109197
      RRM_SF; RNA recognition motif (RRM) superfamily
    2. NM_001330555.1NP_001317484.1  transformer-2 protein homolog beta isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in the 5' region and initiates translation from a downstream start codon compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC154605, AI847347, AK049573, CA576639, CT009567
      Consensus CDS
      CCDS84216.1
      UniProtKB/Swiss-Prot
      P62996
      UniProtKB/TrEMBL
      F8WJG3
      Conserved Domains (1) summary
      cd12641
      Location:997
      RRM_TRA2B; RNA recognition motif in Transformer-2 protein homolog beta (TRA-2 beta) and similar proteins
    3. NM_009186.5NP_033212.1  transformer-2 protein homolog beta isoform 1

      See identical proteins and their annotated locations for NP_033212.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC154605, AI847347, AK049573, CT009567
      Consensus CDS
      CCDS37297.1
      UniProtKB/Swiss-Prot
      P62996
      Related
      ENSMUSP00000124846.1, OTTMUSP00000048838, ENSMUST00000161286.7, OTTMUST00000089370
      Conserved Domains (1) summary
      cl17169
      Location:109197
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      22245741..22266000 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521877.1XP_006521940.1  transformer-2 protein homolog beta isoform X1

      Conserved Domains (1) summary
      cl17169
      Location:109197
      RRM_SF; RNA recognition motif (RRM) superfamily
    2. XM_017316896.1XP_017172385.1  transformer-2 protein homolog beta isoform X3

    3. XM_006521879.3XP_006521942.1  transformer-2 protein homolog beta isoform X2

      Related
      ENSMUSP00000023564.9, OTTMUSP00000048840, ENSMUST00000023564.9, OTTMUST00000089375
      Conserved Domains (1) summary
      cd12641
      Location:997
      RRM_TRA2B; RNA recognition motif in Transformer-2 protein homolog beta (TRA-2 beta) and similar proteins
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