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    Tra2b transformer 2 beta [ Mus musculus (house mouse) ]

    Gene ID: 20462, updated on 29-Jun-2021

    Summary

    Official Symbol
    Tra2bprovided by MGI
    Official Full Name
    transformer 2 betaprovided by MGI
    Primary source
    MGI:MGI:106016
    See related
    Ensembl:ENSMUSG00000022858
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sfr; Sil; SIG-41; Sfrs10; Silg41; TRA2beta; D16Ertd266e; 5730405G21Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 57.4), CNS E14 (RPKM 44.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Tra2b in Genome Data Viewer
    Location:
    16 B1; 16 13.18 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (22063302..22084755, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (22244552..22266005, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (22245814..22266002, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L35a-like Neighboring gene transmembrane protein 97 pseudogene Neighboring gene G protein subunit gamma 5, pseudogene Neighboring gene ets variant 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (4)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC102169

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables poly-purine tract binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables pre-mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables pre-mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in nuclear inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transformer-2 protein homolog beta
    Names
    silica-induced gene 41 protein
    splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)
    transformer 2 beta homolog
    transformer-2 protein homolog B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330554.1NP_001317483.1  transformer-2 protein homolog beta isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AC154605, AI847347, AK049573, CT009567, DV647445
      UniProtKB/Swiss-Prot
      P62996
      Conserved Domains (1) summary
      cd12363
      Location:117196
      RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins
    2. NM_001330555.1NP_001317484.1  transformer-2 protein homolog beta isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in the 5' region and initiates translation from a downstream start codon compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC154605, AI847347, AK049573, CA576639, CT009567
      Consensus CDS
      CCDS84216.1
      UniProtKB/Swiss-Prot
      P62996
      UniProtKB/TrEMBL
      F8WJG3
      Related
      ENSMUSP00000023564.10, ENSMUST00000023564.10
      Conserved Domains (1) summary
      cd12641
      Location:1197
      RRM_TRA2B; RNA recognition motif (RRM) found in Transformer-2 protein homolog beta (TRA-2 beta) and similar proteins
    3. NM_009186.5NP_033212.1  transformer-2 protein homolog beta isoform 1

      See identical proteins and their annotated locations for NP_033212.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC154605, AI847347, AK049573, CT009567
      Consensus CDS
      CCDS37297.1
      UniProtKB/Swiss-Prot
      P62996
      Related
      ENSMUSP00000124846.2, ENSMUST00000161286.8
      Conserved Domains (1) summary
      cd12363
      Location:117196
      RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      22063302..22084755 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316896.2XP_017172385.1  transformer-2 protein homolog beta isoform X1

      Conserved Domains (1) summary
      cd12641
      Location:1197
      RRM_TRA2B; RNA recognition motif (RRM) found in Transformer-2 protein homolog beta (TRA-2 beta) and similar proteins
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