U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    EPHA5 EPH receptor A5 [ Homo sapiens (human) ]

    Gene ID: 2044, updated on 23-Sep-2022

    Summary

    Official Symbol
    EPHA5provided by HGNC
    Official Full Name
    EPH receptor A5provided by HGNC
    Primary source
    HGNC:HGNC:3389
    See related
    Ensembl:ENSG00000145242 MIM:600004; AllianceGenome:HGNC:3389
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EK7; CEK7; EHK1; HEK7; EHK-1; TYRO4
    Summary
    This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Aug 2013]
    Expression
    Biased expression in brain (RPKM 4.9), ovary (RPKM 1.0) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See EPHA5 in Genome Data Viewer
    Location:
    4q13.1-q13.2
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (65319567..65670489, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (68756500..69108844, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (66185285..66536207, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900852 Neighboring gene long intergenic non-protein coding RNA 2835 Neighboring gene ribosomal protein L6 pseudogene 10 Neighboring gene EPHA5 antisense RNA 1 Neighboring gene uncharacterized LOC105377258 Neighboring gene RNA, U2 small nuclear 40, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GPI-linked ephrin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ephrin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transmembrane-ephrin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transmembrane-ephrin receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cAMP-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ephrin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hippocampus development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in neuron development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of CREB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of insulin secretion involved in cellular response to glucose stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in rough endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ephrin type-A receptor 5
    Names
    EPH homology kinase 1
    EPH-like kinase 7
    brain-specific kinase
    epididymis secretory sperm binding protein
    receptor protein-tyrosine kinase HEK7
    tyrosine-protein kinase receptor EHK-1
    NP_001268694.1
    NP_001268695.1
    NP_001268696.1
    NP_001305690.1
    NP_004430.4
    NP_872272.2
    XP_005265710.1
    XP_011530037.1
    XP_016863367.1
    XP_016863369.1
    XP_016863370.1
    XP_047305718.1
    XP_047305719.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281765.3NP_001268694.1  ephrin type-A receptor 5 isoform c

      See identical proteins and their annotated locations for NP_001268694.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest protein (isoform c).
      Source sequence(s)
      AC018683, AC104137, BC136257, BX537946
      Consensus CDS
      CCDS75133.1
      UniProtKB/Swiss-Prot
      P54756
      UniProtKB/TrEMBL
      B7ZKJ3
      Related
      ENSP00000480763.1, ENST00000622150.4
      Conserved Domains (7) summary
      cd09546
      Location:9661031
      SAM_EPH-A5; SAM domain of EPH-A5 subfamily of tyrosine kinase receptors
      smart00454
      Location:9701028
      SAM; Sterile alpha motif
      cd10483
      Location:60232
      EphR_LBD_A5; Ligand Binding Domain of Ephrin type-A Receptor 5
      cd00063
      Location:469559
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:671937
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam07714
      Location:676933
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:579671
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    2. NM_001281766.3NP_001268695.1  ephrin type-A receptor 5 isoform d

      See identical proteins and their annotated locations for NP_001268695.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon in the coding region compared to variant 3. The resulting protein (isoform d) is shorter but has the same N- and C-termini compared to isoform c.
      Source sequence(s)
      AC018683, AC104137, BC143427, BX537946
      Consensus CDS
      CCDS75131.1
      UniProtKB/Swiss-Prot
      P54756
      UniProtKB/TrEMBL
      B7ZKW7
      Related
      ENSP00000478537.1, ENST00000613740.5
      Conserved Domains (7) summary
      cd09546
      Location:9441009
      SAM_EPH-A5; SAM domain of EPH-A5 subfamily of tyrosine kinase receptors
      smart00454
      Location:9481006
      SAM; Sterile alpha motif
      cd10483
      Location:60232
      EphR_LBD_A5; Ligand Binding Domain of Ephrin type-A Receptor 5
      cd00063
      Location:469559
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:649915
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam07714
      Location:654911
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:579649
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    3. NM_001281767.3NP_001268696.1  ephrin type-A receptor 5 isoform e

      See identical proteins and their annotated locations for NP_001268696.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) includes a 3' terminal exon that extends past a splice site used in variant c, resulting in a different 3' coding region and 3' UTR. The resulting protein (isoform e) is shorter and has a distinct C-terminus compared to isoform c.
      Source sequence(s)
      AB209375, AC018683, AC104137, BM664168, H11658
      Consensus CDS
      CCDS75132.1
      UniProtKB/TrEMBL
      F8VP57, Q59FT4
      Related
      ENSP00000427638.1, ENST00000511294.1
      Conserved Domains (6) summary
      cd10483
      Location:60232
      EphR_LBD_A5; Ligand Binding Domain of Ephrin type-A Receptor 5
      cd00063
      Location:469559
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:671937
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam00041
      Location:359447
      fn3; Fibronectin type III domain
      pfam14575
      Location:576673
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl15755
      Location:9661004
      SAM_superfamily; SAM (Sterile alpha motif )
    4. NM_001318761.2NP_001305690.1  ephrin type-A receptor 5 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 3. The resulting protein (isoform f) has a shorter N-terminus compared to isoform c.
      Source sequence(s)
      AC018683, BC136258, BX537946
      UniProtKB/Swiss-Prot
      P54756
      UniProtKB/TrEMBL
      B7ZKJ3
      Conserved Domains (7) summary
      cd09546
      Location:897962
      SAM_EPH-A5; SAM domain of EPH-A5 subfamily of tyrosine kinase receptors
      smart00454
      Location:901959
      SAM; Sterile alpha motif
      cd00063
      Location:400490
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:602868
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam07714
      Location:607864
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:510602
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl02704
      Location:1163
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
    5. NM_004439.8NP_004430.4  ephrin type-A receptor 5 isoform a

      See identical proteins and their annotated locations for NP_004430.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) used an alternate splice site in the coding region compared to variant 3. The resulting protein (isoform a) is shorter but has the same N- and C-termini compared to isoform c.
      Source sequence(s)
      AB209375, AC018683, AC104137, BC136257, BX537946, X95425
      Consensus CDS
      CCDS3513.1
      UniProtKB/Swiss-Prot
      P54756, Q7Z3F2
      UniProtKB/TrEMBL
      A0A384MU00, B7ZKJ3, Q59FT4
      Related
      ENSP00000273854.3, ENST00000273854.7
      Conserved Domains (6) summary
      cd09546
      Location:9651030
      SAM_EPH-A5; SAM domain of EPH-A5 subfamily of tyrosine kinase receptors
      cd10483
      Location:60232
      EphR_LBD_A5; Ligand Binding Domain of Ephrin type-A Receptor 5
      cd00063
      Location:469559
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:670936
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam00041
      Location:359447
      fn3; Fibronectin type III domain
      pfam14575
      Location:578670
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    6. NM_182472.5NP_872272.2  ephrin type-A receptor 5 isoform b

      See identical proteins and their annotated locations for NP_872272.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site and lacks an alternate exon in the coding region compared to variant 3. The resulting protein (isoform b) is shorter but has the same N- and C-termini compared to isoform c.
      Source sequence(s)
      AB209375, AC018683, AC104137, BC136257, BX537946, L36644, X95425
      Consensus CDS
      CCDS3514.1
      UniProtKB/Swiss-Prot
      P54756
      UniProtKB/TrEMBL
      B7ZKJ3, Q59FT4
      Related
      ENSP00000346899.4, ENST00000354839.8
      Conserved Domains (7) summary
      cd09546
      Location:9431008
      SAM_EPH-A5; SAM domain of EPH-A5 subfamily of tyrosine kinase receptors
      smart00454
      Location:9471005
      SAM; Sterile alpha motif
      cd10483
      Location:60232
      EphR_LBD_A5; Ligand Binding Domain of Ephrin type-A Receptor 5
      cd00063
      Location:469559
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:648914
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam07714
      Location:653910
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:578648
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      65319567..65670489 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449763.1XP_047305719.1  ephrin type-A receptor 5 isoform X5

    2. XM_017007880.3XP_016863369.1  ephrin type-A receptor 5 isoform X6

    3. XM_005265653.5XP_005265710.1  ephrin type-A receptor 5 isoform X4

      UniProtKB/TrEMBL
      F8W9W0
      Related
      ENSP00000389208.2, ENST00000432638.6
      Conserved Domains (7) summary
      cd09546
      Location:802867
      SAM_EPH-A5; SAM domain of EPH-A5 subfamily of tyrosine kinase receptors
      smart00454
      Location:806864
      SAM; Sterile alpha motif
      cd10483
      Location:60232
      EphR_LBD_A5; Ligand Binding Domain of Ephrin type-A Receptor 5
      cd00063
      Location:305395
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:507773
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam07714
      Location:512769
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:415507
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    4. XM_047449762.1XP_047305718.1  ephrin type-A receptor 5 isoform X3

    5. XM_017007878.3XP_016863367.1  ephrin type-A receptor 5 isoform X2

    6. XM_011531735.4XP_011530037.1  ephrin type-A receptor 5 isoform X1

      Conserved Domains (7) summary
      cd09546
      Location:854919
      SAM_EPH-A5; SAM domain of EPH-A5 subfamily of tyrosine kinase receptors
      smart00454
      Location:858916
      SAM; Sterile alpha motif
      cd10483
      Location:60232
      EphR_LBD_A5; Ligand Binding Domain of Ephrin type-A Receptor 5
      cd00063
      Location:357447
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:559825
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam07714
      Location:564821
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:467559
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    7. XM_017007881.3XP_016863370.1  ephrin type-A receptor 5 isoform X7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      68756500..69108844 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)