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    Sem1 SEM1, 26S proteasome complex subunit [ Mus musculus (house mouse) ]

    Gene ID: 20422, updated on 8-Jul-2021

    Summary

    Official Symbol
    Sem1provided by MGI
    Official Full Name
    SEM1, 26S proteasome complex subunitprovided by MGI
    Primary source
    MGI:MGI:109238
    See related
    Ensembl:ENSMUSG00000042541
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DS; Shf; DSS1; Shfg; Shfm; Shfdg; Shfm1; Shfdg1
    Expression
    Broad expression in CNS E11.5 (RPKM 292.2), placenta adult (RPKM 118.3) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Sem1 in Genome Data Viewer
    Location:
    6; 6 A1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (6558275..6578658, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (6558275..6578658, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (6508275..6528658, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene 20619 Neighboring gene predicted gene 8652 Neighboring gene predicted gene, 52888 Neighboring gene predicted gene, 52889 Neighboring gene predicted gene 20618 Neighboring gene predicted gene, 18006 Neighboring gene predicted gene, 53309

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA export from nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteasome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of integrator complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of proteasome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome regulatory particle, lid subcomplex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    26S proteasome complex subunit SEM1
    Names
    26S proteasome complex subunit DSS1
    deleted in split hand/split foot protein 1 homolog
    split hand/foot deleted gene 1
    split hand/foot deleted protein 1 homolog
    split hand/foot malformation (ectrodactyly) type 1
    split hand/foot malformation type 1 protein homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009169.2NP_033195.1  26S proteasome complex subunit SEM1

      See identical proteins and their annotated locations for NP_033195.1

      Status: VALIDATED

      Source sequence(s)
      AC124582, AK160432
      Consensus CDS
      CCDS39422.1
      UniProtKB/Swiss-Prot
      P60897
      UniProtKB/TrEMBL
      Q3TV35
      Related
      ENSMUSP00000040741.9, ENSMUST00000041111.10
      Conserved Domains (1) summary
      pfam05160
      Location:2362
      DSS1_SEM1; DSS1/SEM1 family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      6558275..6578658 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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